Skeletal muscle fat infiltration: impact of age, inactivity, and exercise
Open accessAbstract
Fat infiltration within the fascial envelope of the thigh or intermuscular adispose tissue (IMAT), has been shown to be associated with both adverse metabolic and mobility impairments in older individuals. More recent findings suggest these fat deposits may be associated with increasing age and inactivity; and perhaps exercise may be able to counter or mitigate this increase in IMAT. This brief report summarizes the literature with respect to IMAT and its relationship to increasing age, physical activity levels, muscle strength, mobility and metabolism in the elderly. Further, we present preliminary data suggesting that IMAT is associated with increasing age in individuals across disease states (r=0.47, p < 0.05), and that resistance exercise can decrease IMAT in older individuals with a variety of co-morbid conditions.
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A decrease in muscle fat infiltration was shown in some but not all previous studies of RT alone in nonobese persons.
“A decrease in muscle fat infiltration was shown in some (42,43) but not all (44) previous studies of RT alone in nonobese persons.”
From Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial (2015) · cites this paper as [43]
The Results (Aim 2; page unavailable) report an 11.0% decrease in thigh intermuscular adipose tissue after 12 weeks of resistance training, supporting the claim that a previous RT-only study found a decrease. The Methods (Participants; page unavailable) do not specify that this cohort was nonobese, so that population qualifier is not established by our copy. (LLM, conf=0.81)
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- Authors
- Marcus, R. L., Addison, O., Kidde, J. P., Dibble, L. E., & Lastayo, P. C.
- Affiliations
- University of Utah (US)
- Venue
- The Journal of nutrition, health and aging
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 14
- Issue
- 5
- Pages
- 362-366
- ISSN
- 1279-7707 (ISSN-L)
- PMC
- PMC3758242
- OpenAlex
- W1993419506
- Cited by
- 449
- References
- 50
- Citations by year
- 2026: 26 · 2025: 41 · 2024: 36 · 2023: 31 · 2022: 51 · 2021: 45 · 2020: 44 · 2019: 28 · 2018: 29 · 2017: 23 · 2016: 28 · 2015: 23 · 2014: 19 · 2013: 9 · 2012: 12
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k12hd043449-05)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12 HD043449)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- skeletal muscle fat infiltration, intermuscular adipose tissue, thigh fat, aging, physical inactivity, resistance training, older adults, mobility (physical function), muscle strength, metabolism, comorbidities
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Body Composition, Female, Humans, Male, Middle Aged, Exercise, Muscle, Skeletal, Resistance Training, Young Adult
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