Enhanced Biocompatibility in Biostable Poly(carbonate)urethane
Abstract
Summary: In this work, we synthesized two MDI‐based polyurethanes, including a poly(ether)urethane (PEU) and a poly(carbonate)urethane (PCU), by using different soft segments, poly(tetramethylene oxide) and poly(hexyl, ethyl)carbonate diol ($\overline M$ ∼ 2 000). We demonstrated that, in addition to the enhanced biostability of PCU over PEU, the biological performances of PCU in vitro were also improved in general. These included, better cellular attachment and proliferation, less platelet activation, as well as reduced monocyte activation. The unusual wide‐ranging enhancement in biocompatibility for PCU was believed to be related to the larger micro‐phase separation in PCU (∼25 nm) that caused distinct protein adsorption on the surface. The total number of adherent monocytes (nonactivated and activated) on the bare sample surfaces, albumin pre‐adsorbed sample surfaces, and fibrinogen pre‐adsorbed sample surfaces. imageThe total number of adherent monocytes (nonactivated and activated) on the bare sample surfaces, albumin pre‐adsorbed sample surfaces, and fibrinogen pre‐adsorbed sample surfaces.
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Polymer surfaces with segmented block co-polymers that form phase-separated structures exhibit less bacterial adhesion and cell attachment.
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Self-citation
- Authors
- Hsu, S., Kao, Y., & Lin, Z.
- Affiliations
- National Chung Hsing University (TW)
- Corresponding author
- Hsu, Shan‐hui
- ORCID
- Hsu, Shan‐hui
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2004-04-13
- Volume
- 4
- Issue
- 4
- Pages
- 464-470
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2153893069
- Cited by
- 33
- References
- 20
- Citations by year
- 2026: 2 · 2024: 2 · 2022: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Bioscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- polycarbonate urethane, polyether polyurethane, biocompatibility, biostability, poly(tetramethylene oxide), soft segment, microphase separation, protein adsorption, platelet activation, monocyte activation, albumin, fibrinogen
- MeSH terms
- Adsorption, Biocompatible Materials, Fibrinogen, Materials Testing, Microscopy, Electron, Scanning, Molecular Weight, Polymers, Polyurethanes, Serum Albumin, Surface Properties, Thermodynamics, Microscopy, Atomic Force
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