Biocompatibility of Poly(carbonate urethane)s with Various Degrees of Nanophase Separation
Abstract
Summary: Nanophase separation has been suggested to influence the biological performance of polyurethane. In a previous work (Macromol. Biosci. 2004, 4, 891), six different 4,4′‐diphenylmethane diisocyanate (MDI)‐based poly(carbonate urethane)s (PCUs) that exhibited various degrees of nanophase separation were synthesized and characterized. In the present work, these PCUs were used as a model system to study the effect of nanometric structures on the biocompatibility of polyurethane. Human blood platelet activation, monocyte activation, protein adsorption, and bacterial adhesion on PCU were investigated in vitro. It was found that human blood platelets as well as monocytes were less activated on the PCU surfaces with a greater degree of nanophase separation in general. This phenomenon was closely associated with the lower ratio of human fibrinogen/albumin competitively adsorbed on these surfaces. Bacterial adhesion was also inhibited in some nanophase‐separated PCUs. The morphology of a platelet on a PCU studied here. magnified imageThe morphology of a platelet on a PCU studied here.
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Polymer surfaces with segmented block co-polymers that form phase-separated structures exhibit less bacterial adhesion and cell attachment.
“Some studies have demonstrated that polymer surfaces with segmented block co-polymers (hard and soft domains) that result in phase-separated structures also exhibit less bacterial adhesion and cell attachment.61–63”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [62]
Cites
Dalby, M. J., Yarwood, S. J., Riehle, M. O., Johnstone, H., Affrossman, S., & Curtis, A. S. G. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5498 · Cited by 354 · see citing works
Pinchuk, L. (1995) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856294x00347 · Cited by 252 · see citing works
Rapid fibroblast adhesion to 27 nm high polymer demixed nano-topography
Dalby, M. J., Giannaras, D., Riehle, M. O., Gadegaard, N., Affrossman, S., & Curtis, A. S. G. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00475-7 · Cited by 236 · see citing works
Surface properties and blood compatibility of polyurethaneureas
Grasel, T. G., & Cooper, S. L. (1986) · Biomaterials · doi:10.1016/0142-9612(86)90002-5 · Cited by 122 · see citing works
On-Line Detection of Nonspecific Protein Adsorption at Artificial Surfaces
Ros, R., Harder, P., Dahint, R., Grunze, M., Josse, F. J., Mrksich, M., & Whitesides, G. M. (1997) · Analytical Chemistry · doi:10.1021/ac970047b · Cited by 115 · see citing works
Nanoscopic behavior of polyvinylpyrrolidone particles on polysulfone/polyvinylpyrrolidone film
Hayama, M., Yamamoto, K.-I., Kohori, F., Uesaka, T., Ueno, Y., Sugaya, H., Itagaki, I., & Sakai, K. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00629-x · Cited by 99 · see citing works
Bakker, D. P., Busscher, H. J., van Zanten, J., de Vries, J., Klijnstra, J. W., & van der Mei, H. C. (2004) · Microbiology · doi:10.1099/mic.0.26983-0 · Cited by 90 · see citing works
Texturing of polymer surfaces at the cellular level
Schmidt, J. A., & von Recum, A. F. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90006-v · Cited by 89 · see citing works
Kao, W. J., Zhao, Q. H., Hiltner, A., & Anderson, J. M. (1994) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820280110 · Cited by 85 · see citing works
Hsu, S., Tang, C.-M., & Lin, C.-C. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.01.061 · Cited by 75 · see citing works
Self-citationTanner, J., Carlén, A., Söderling, E. M., & VALLITTU, P. K. (2003) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.10012 · Cited by 67 · see citing works
Hemocompatibilty of new ionic polyurethanes: influence of carboxylic group insertion modes
Poussard, L., Burel, F., Couvercelle, J., Merhi, Y., Tabrizian, M., & Bunel, C. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.10.069 · Cited by 66 · see citing works
Microphase separated structure and protein adsorption of polyurethanes with butadiene soft segment
Huang, S., Chao, M., Ruaan, R., & Lai, J. (2000) · European Polymer Journal · doi:10.1016/s0014-3057(99)00063-4 · Cited by 56 · see citing works
Synthesis, characterization and ex vivo evaluation of poly-dimethylsiloxane polyurea-urethanes
Lim, F., Yang, C.-Z., & Cooper, S. L. (1994) · Biomaterials · doi:10.1016/0142-9612(94)90218-6 · Cited by 54 · see citing works
Microbial adhesion to ionogenic PHEMA, PU and PP implants
Kiremitçi-Gümüşderelioğlu, M. (1996) · Biomaterials · doi:10.1016/0142-9612(96)89662-1 · Cited by 53 · see citing works
Structure and Adsorption Properties of Fibrinogen
Feng, L., & Andrade, J. D. (1995) · ACS symposium series · doi:10.1021/bk-1995-0602.ch005 · Cited by 44 · see citing works
Hsu, S., Tseng, H., & Wu, M. (2000) · Artificial Organs · doi:10.1046/j.1525-1594.2000.06338.x · Cited by 40 · see citing works
Self-citationVoie, Ø. A., Tysklind, M., Andersson, P. L., & Fonnum, F. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.8977 · Cited by 37 · see citing works
Enhanced Biocompatibility in Biostable Poly(carbonate)urethane
Hsu, S., Kao, Y., & Lin, Z. (2004) · Macromolecular Bioscience · doi:10.1002/mabi.200300082 · Cited by 33 · see citing works
Self-citationIn vitro activation of human monocytes by silicones
Naim, J. O., van Oss, C. J., Ippolito, K. M. L., Zhang, J.-W., Jin, L.-P., Fortuna, R., & Buehner, N. A. (1998) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(98)00023-x · Cited by 32 · see citing works
In vivo leucocyte interactions on Pellethane® surfaces
Brunstedt, M. R., Anderson, J. M., Spilizewski, K. L., Marchant, R. E., & Hiltner, A. (1990) · Biomaterials · doi:10.1016/0142-9612(90)90089-9 · Cited by 32 · see citing works
Hsu, S., & Kao, Y. (2004) · Macromolecular Bioscience · doi:10.1002/mabi.200400062 · Cited by 21 · see citing works
Self-citationHsu, S., & Chen, J.-Y. (1999) · Polymer Degradation and Stability · doi:10.1016/s0141-3910(98)00219-5 · Cited by 18 · see citing works
Self-citationModel experiments on platelet adhesion in stagnation point flow
Wurzinger, L. J., Blasberg, P., van de Loecht, M., Suwelack, W., & Schmid-Schönbein, H. (1984) · Biorheology · doi:10.3233/bir-1984-21422 · Cited by 10 · see citing works
Kim, J. H., & Kim, S. (2003) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/15685620360674281 · Cited by 8 · see citing works
Yamaguchi, H., Takeuchi, H., Torikata, C., Ashizawa, M., & Shiobara, H. (1977) · Experimentelle Pathologie · doi:10.1016/s0014-4908(77)80076-8 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Influence of nanoscale surface topography on protein adsorption and cellular response
Lord, M. S., Foss, M., & Besenbacher, F. (2010) · Nano Today · doi:10.1016/j.nantod.2010.01.001 · Cited by 605 · see citing works
Proteins, platelets, and blood coagulation at biomaterial interfaces
Xu, L.-C., Bauer, J. W., & Siedlecki, C. A. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.09.040 · Cited by 391 · see citing works
Eceiza, A., Martin, L., de la Caba, K., Kortaberría, G., Gabilondo, N., Corcuera, M. Á., & Mondragòn, I. (2007) · Polymer Engineering and Science · doi:10.1002/pen.20905 · Cited by 278 · see citing works
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Agricultural Waste Fibers Towards Sustainability and Advanced Utilization: A Review
Dungani, R., Karina, M., Subyakto, S., Sulaeman, A., Hermawan, D., & Hadiyane, A. (2015) · Asian Journal of Plant Sciences · doi:10.3923/ajps.2016.42.55 · Cited by 184 · see citing works
“…skins replacements for burnings and wounds; drugs releasing system; blood vessel growth; nerves, gum and dura-mater reconstruction; scaffolds for tissue engineering; stent covering and bone reconstruction (Hsu and Kao, 2005; Millon et al., 2006; Macocinschi et al., 2012; Musteata et al., 2010).”
BackgroundDegradation studies on segmented polyurethanes prepared with HMDI, PCL and different chain extenders
Chan‐Chan, L. H., Solís-Correa, R. E., Vargas‐Coronado, R. F., Cervantes‐Uc, J. M., Cauich-Rodríguez, J. V., Quintana, P., & Bartolo-Pérez, P. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.12.010 · Cited by 145 · see citing works
Kultys, A., Rogulska, M., Pikus, S., & Skrzypiec, K. (2009) · European Polymer Journal · doi:10.1016/j.eurpolymj.2009.06.003 · Cited by 88 · see citing works
Biocompatibility of poly(ether)urethane‐gold nanocomposites
Hsu, S., Tang, C., & Tseng, H. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30879 · Cited by 71 · see citing works
Self-citationPolyurethane Shape‐Memory Polymers Demonstrate Functional Biocompatibility In Vitro
Cabanlit, M., Maitland, D., Wilson, T., Simon, S., Wun, T., Gershwin, M. E., & Van de Water, J. (2007) · Macromolecular Bioscience · doi:10.1002/mabi.200600177 · Cited by 69 · see citing works
Xu, L., & Siedlecki, C. A. (2015) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33592 · Cited by 69 · see citing works
Hsu, S., Tang, C., & Tseng, H. (2007) · Biomacromolecules · doi:10.1021/bm700471k · Cited by 58 · see citing works
Self-citationXu, L., Runt, J. P., & Siedlecki, C. A. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.11.031 · Cited by 42 · see citing works
Xu, L., Li, Z., Tian, Z., Chen, C., Allcock, H. R., & Siedlecki, C. A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.11.056 · Cited by 40 · see citing works
In-vivo degradation of poly(carbonate-urethane) based spine implants
Cipriani, E., Bracco, P., Kurtz, S. M., Costa, L., & Zanetti, M. (2013) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2013.03.005 · Cited by 39 · see citing works
“In particular, the extent of phase separation has a n influence on the cell attachment and proliferation [16,17].”
BackgroundSegmented biopolyurethanes for medical applications
Macocinschi, D., Filip, D., Vlad, S., Cristea, M., & Butnaru, M. (2009) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-009-3731-3 · Cited by 35 · see citing works
3D printing of polyurethane biomaterials
Hung, K., Tseng, C., & Hsu, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100614-6.00005-6 · Cited by 34 · see citing works
Self-citationVakili, H., Mohseni, M., Makki, H., Yahyaei, H., Ghanbari, H., González, A., & Irusta, L. (2020) · Polymer · doi:10.1016/j.polymer.2020.122424 · Cited by 34 · see citing works
Solís-Correa, R. E., Vargas‐Coronado, R. F., Aguilar-Vega, M. J., Cauich‐Rodríguez, J. V., Román, J. S., & Marcos-Fernández, Á. A. (2007) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856207780852488 · Cited by 34 · see citing works
Microphase separation structure influences protein interactions with poly(urethane urea) surfaces
Xu, L., & Siedlecki, C. A. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32340 · Cited by 31 · see citing works
Conn, G., Kidane, A. G., Punshon, G., Kannan, R. Y., Hamilton, G., & Seifalian, A. M. (2006) · Expert Review of Medical Devices · doi:10.1586/17434440.3.2.245 · Cited by 29 · see citing works
Xu, L.-C., Soman, P., Runt, J., & Siedlecki, C. A. (2007) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856207780425013 · Cited by 25 · see citing works
Thermal and Physico-Mechanical Characterizations of Thromboresistant Polyurethane Films
Wilson, A. C., Chou, S., Lozano, R., Chen, J. Y., & Neuenschwander, P. F. (2019) · Bioengineering · doi:10.3390/bioengineering6030069 · Cited by 22 · see citing works
“Polyurethanes (PUs) are widely used in many biomedical applications due to their excellent biocompatibility [7,8] and slow degradability [9–11].”
Waste-Derived Cellulosic Fibers and Their Applications
Samrot, A. V., Ngaakudzwe, K. T., Rajalakshmi, D., Prakash, P., Kumar, S. S., Chandramohan, M. S., Anand, D. A., Mercy, J. L., Yishak, S., & Saigeetha, S. (2022) · Advances in Materials Science and Engineering · doi:10.1155/2022/7314694 · Cited by 22 · see citing works
A review on the methods of preparation of pharmaceutical nanoparticles
Adibkia, K., Barzegar-Jalali, M., Nokhoudchi, A., Shadbad, M. R. S., Omidi, Y., Javadzadeh, Y., & Mohammadi, G. (2010) · Figshare · Cited by 22 · see citing works
Kultys, A., Rogulska, M., & Pikus, S. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.34102 · Cited by 21 · see citing works
Stefanović, I. S., Djonlagić, J., Tovilović-Kovačević, G., Brkljačić, J. M., Antić, V., Ostojić, S., & Pergal, M. V. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35285 · Cited by 17 · see citing works
Yan, C. S., Hu, S., Fei, Q., Zhang, B., & Wu, W. (2025) · ACS Omega · doi:10.1021/acsomega.5c05108 · Cited by 14 · see citing works
Chi, T.-Y., Yeh, H.-Y., Lin, J., Jeng, U., & Hsu, S. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20113a · Cited by 12 · see citing works
Self-citationMadival, A. S., Deepak, D., & Shetty, R. (2023) · Materials Today Proceedings · doi:10.1016/j.matpr.2023.04.519 · Cited by 11 · see citing works
Kalogeras, I. M., Roussos, M., Vassilikou‐Dova, A., Spanoudaki, A., Pissis, P., Savelyev, Y., Shtompel, V. I., & Robota, L. P. (2005) · The European Physical Journal E · doi:10.1140/epje/e2005-00048-3 · Cited by 10 · see citing works
Fang, H., Feng, L., You, B., & Wu, L. (2006) · Journal of Polymer Science Part B Polymer Physics · doi:10.1002/polb.21034 · Cited by 9 · see citing works
Alwine, S., Chen, C., Shen, L., Allcock, H. R., Siedlecki, C. A., & Xu, L. (2023) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35252 · Cited by 8 · see citing works
Cell migration on nanophase-separated poly(carbonate urethane)s
Hsu, S., Chen, C. A., Chao, C.-N., Chen, C. H., & Chiu, J. J. (2007) · Journal of Medical and Biological Engineering · Cited by 8 · see citing works
Self-citationNatural-Based Polyurethane Biomaterials for Medical Applications
Macocinschi, D., Filip, D., & Vl, S. (2011) · InTech eBooks · doi:10.5772/24219 · Cited by 5 · see citing works
“For poly(carbonate urethane)s with various degree of nanophase segregation the number of platelet adhered found was 5.33 x 106 up to 10.67 x 106 (for Pellethane is 8x106), (Hsu & Kao, 2005).”
BackgroundInfluentialMatrix Protein Interactions with Synthetic Surfaces
Rico, P., Cantini, M., Altankov, G., & Salmerón‐Sánchez, M. (2014) · Wiley eBooks · doi:10.1002/9781118356692.ch3 · Cited by 5 · see citing works
Moo-Espinosa, J., Solís-Correa, R. E., Vargas‐Coronado, R. F., Cervantes‐Uc, J. M., Cauich-Rodríguez, J. V., Owen, P. Q., Aguilar-Santamaría, M. D. L. Á., Fernández‐Gutiérrez, M., & del Barrio, J. S. R. (2013) · Journal of Biomaterials Applications · doi:10.1177/0885328212436706 · Cited by 4 · see citing works
Xu, L., Soman, P., Agnihotri, A., & Siedlecki, C. A. (2009) · Springer eBooks · doi:10.1007/978-0-387-98161-1_3 · Cited by 3 · see citing works
Sandwich-like systems to engineer the cellular microenvironment
Ballester‐Beltrán, J. (2014) · doi:10.4995/thesis/10251/48166
- Authors
- Hsu, S., & Kao, Y.
- Affiliations
- National Chung Hsing University (TW)
- Corresponding author
- Hsu, Shan‐hui
- ORCID
- Hsu, Shan‐hui
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2005-03-14
- Volume
- 5
- Issue
- 3
- Pages
- 246-253
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2087184695
- Cited by
- 39
- References
- 26
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Bioscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- nanophase separation, biocompatibility, polyurethane, 4,4'-diphenylmethane diisocyanate, platelet activation, monocyte activation, protein adsorption, bacterial adhesion, nanostructured surfaces
- MeSH terms
- Bacillus subtilis, Biocompatible Materials, Blood Cells, Blood Physiological Phenomena, Humans, Polyurethanes, Nanotechnology
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