The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Vascularization in Bone Tissue Engineering: Physiology, Current Strategies, Major Hurdles and Future Challenges
Open accessAbstract
The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of ‘successful’ laboratory‐based bone tissue engineering strategies. To the present, grafts have been dependent on post‐implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the establishment of a microcirculation in the engineered constructs has become a major goal for the tissue engineering research community. This review addresses the role and importance of the development of a vascular network in bone tissue engineering and provides an overview of the most up to date research efforts to develop such a network. magnified image
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Creation of long-lasting blood vessels
Koike, N., Fukumura, D., Gralla, O., Au, P., Schechner, J. S., & Jain, R. K. (2004) · Nature · doi:10.1038/428138a · Cited by 701
Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications
Hollinger, J. O., Hart, C. E., Hirsch, S. N., Lynch, S., & Friedlaender, G. E. (2008) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.g.01231 · Cited by 353
Biomaterial–microvasculature interactions
Sieminski, A. L., & Gooch, K. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00149-6 · Cited by 155
Cited by
Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration
Tang, D., Tare, R. S., Yang, L.-Y., Williams, D. F., Ou, K.-L., & Oreffo, R. O. C. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.024 · Cited by 613
3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy.
Ma, H., Feng, C., Chang, J., & Wu, C. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.026 · Cited by 512
Bioprinting for vascular and vascularized tissue biofabrication
Datta, P., Ayan, B., & Ozbolat, I. T. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.035 · Cited by 431
Vascularized Bone Tissue Engineering: Approaches for Potential Improvement
Nguyen, L. H., Annabi, N., Nikkhah, M., Bae, H., Binan, L., Park, S., Kang, Y., Yang, Y., & Khademhosseini, A. (2012) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2012.0012 · Cited by 313
Ko, E., Yang, K., Shin, J., & Cho, S.-W. (2013) · Biomacromolecules · doi:10.1021/bm4008343 · Cited by 226
Metadata
- Authors
- Santos, M. I., & Reis, R. L.
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2009-12-23
- Volume
- 10
- Issue
- 1
- Pages
- 12-27
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2138298552
- Cited by
- 443
- References
- 3
- FWCI
- 15.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Santos, M. I., & Reis, R. L. (2010). Vascularization in Bone Tissue Engineering: Physiology, Current Strategies, Major Hurdles and Future Challenges. Macromolecular Bioscience. https://doi.org/10.1002/mabi.200900107
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