Cited by 27Advanced Polymer Synthesis and Characterizationbiodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applications

Synthetic Route and Characterization of Main Chain Ester‐Containing Hydrolytically Degradable Poly( N , N ‐dimethylaminoethyl methacrylate)‐Based Polycations

Agarwal, Seema, Ren, Liqun, Kissel, Thomas, Bege, Nadja·2010·Macromolecular Chemistry and Physics

Abstract

Abstract The possibility of introducing hydrolytically cleavable ester linkages onto the poly( N , N ‐dimethylaminoethyl methacrylate) for the formation of less toxic and degradable polycations is shown in this work. For achieving this aim, the copolymerization behavior of 5,6‐benzo‐2‐methylene‐1,3‐dioxepane (BMDO), with N , N ‐dimethylaminoethyl methacrylate (DMAEMA) is studied by free radical ring‐opening polymerization. Structural characterization is performed using 1D and 2D NMR techniques. Under optimized reaction conditions, quantitative ring‐opening of BMDO took place during the copolymerizations leading to the formation of poly(DMAEMA‐ co ‐ester)s. Blocky random copolymers were further quaternized by alkyl bromide to generate degradable cation containing polymers. Cytotoxicity results were highly encouraging and showed less cytotoxicity as compared to polyethyleneimine, which was used as a positive control. The formation and characterization of highly stable copolymer/DNA polyplexes is also shown here. magnified image

Integrity signals

Registry

Crossref · 10.1002/macp.200900579

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Increasing interest in biodegradable polyesters and the versatility of RROP with respect to structures accessible via different monomers and their copolymerization with conventional vinyl monomers has changed the situation significantly.

    “However, with the increasing interest in biodegradable polyesters and the versatility of RROP with respect to the structures accessible via very different monomers [25] and their copolymerization with conventional vinyl monomers [26 -34] has changed the situation significantly.”

    From Ring-Opening Polymerization—An Introductory Review (2013) · cites this paper as [27]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Agarwal, S., Ren, L., Kissel, T., & Bege, N.
Affiliations
Philipps University of Marburg (DE)
Corresponding author
Agarwal, Seema
Venue
Macromolecular Chemistry and Physics
Publisher
Wiley
Published
2010-04-13
Volume
211
Issue
8
Pages
905-915
ISSN
  • 1022-1352 (ISSN-L)
  • 1521-3935
OpenAlex
W2136239884
Cited by
27
References
18
Citations by year
2026: 4 · 2024: 1 · 2022: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 3 · 2012: 3
FWCI
1.90
Type
journal article
Language
en
Open access
closed
Locations
  • Macromolecular Chemistry and Physics (publishedVersion)
  • ERef Bayreuth (University of Bayreuth) (submittedVersion)
Funders
DFG
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
hydrolytically degradable polymers, cationic polymers, poly(N,N-dimethylaminoethyl methacrylate), ring-opening polymerization, quaternization, alkyl bromides, cytotoxicity, polyplexes, DNA delivery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review