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Synthesis and Drug‐Delivery Behavior of Chitosan‐Functionalized Graphene Oxide Hybrid Nanosheets
Abstract
Chitosan‐functionalized graphene oxides (FGOCs) were successfully synthesized. FGOCs were found to significantly improve the solubility of the GO in aqueous acidic media. The presence of organic groups was confirmed by means of XPS and TGA. Restoration of the sp 2 carbon network and exfoliation of graphene sheets were confirmed by Raman spectroscopy, UV‐visible spectroscopy and WAXD. The SEM and AFM investigations of the resultant FGOCs showed that most of the graphene sheets were individual and few were layered. Controlled release behavior of Ibuprofen and 5‐fluorouracil was then investigated. We found that FGOCs are a promising new material for biological and medical applications. magnified image
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Cites
Two-dimensional gas of massless Dirac fermions in graphene
Novoselov, K. S., Geim, A. K., Morozov, S. V., Jiang, D., Katsnelson, M. I., Grigorieva, I. V., Dubonos, S. V., & Firsov, A. A. (2005) · Nature · doi:10.1038/nature04233 · Cited by 21,611
Experimental observation of the quantum Hall effect and Berry's phase in graphene
Zhang, Y., Tan, Y.-W., Stormer, H. L., & Kim, P. (2005) · Nature · doi:10.1038/nature04235 · Cited by 13,435
Graphene-based composite materials
Stankovich, S., Dikin, D. A., Dommett, G. H. B., Kohlhaas, K. M., Zimney, E. J., Stach, E. A., Piner, R. D., Nguyen, S. T., & Ruoff, R. S. (2006) · Nature · doi:10.1038/nature04969 · Cited by 12,922
Cited by
Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
Ou, L., Song, B., Liang, H., Liu, J., Feng, X., Deng, B., Sun, T., & Shao, L. (2016) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0168-y · Cited by 803
Graphene and graphene oxide as nanomaterials for medicine and biology application
Priyadarsini, S., Mohanty, S., Mukherjee, S., Basu, S., & Mishra, M. (2018) · Journal of Nanostructure in Chemistry · doi:10.1007/s40097-018-0265-6 · Cited by 570
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems
Yang, K., Li, Y., Tan, X., Peng, R., & Liu, Z. (2013) · Small · doi:10.1002/smll.201201417 · Cited by 462
Metadata
- Authors
- Rana, V. K., Choi, M., Kong, J., Kim, G. Y., Kim, M. J., Kim, S., Mishra, S., Singh, R. P., & Ha, C.
- Venue
- Macromolecular Materials and Engineering
- Publisher
- Wiley
- Published
- 2010-12-22
- Volume
- 296
- Issue
- 2
- Pages
- 131-140
- ISSN
- 1438-7492 (ISSN-L)
- 1439-2054
- OpenAlex
- W1980710364
- Cited by
- 374
- References
- 3
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rana, V. K., Choi, M., Kong, J., Kim, G. Y., Kim, M. J., Kim, S., Mishra, S., Singh, R. P., & Ha, C. (2011). Synthesis and Drug‐Delivery Behavior of Chitosan‐Functionalized Graphene Oxide Hybrid Nanosheets. Macromolecular Materials and Engineering. https://doi.org/10.1002/mame.201000307
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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