Blood donations, iron stores, and risk of Parkinson's disease
Abstract
Iron overload and systemic iron stores may be important in the pathogenesis of Parkinson's disease (PD). We therefore examined the association between blood donations, which reduce body iron stores, and risk of PD in the Health Professionals Follow-Up Study, a large cohort investigation of U.S. men. Our hypothesis was that blood donation reduces the risk of PD by lowering systemic iron stores. Although the number of blood donations was inversely related to the ferritin levels in a subsample of the study population, no association was found between the number of blood donations and risk of PD (P for trend = 0.6). Unexpectedly, the risk of PD was higher among men who reported recent multiple blood donations (P for trend = 0.05). The results of this study do not support the hypothesis that reduced systemic iron stores lower the risk of PD.
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Reduced concentrations of systemic iron are associated with an increased risk of Parkinson's disease.
“Studies have shown that reduced concentrations of systemic iron are associated with an increased risk of Parkinson’s disease.140–142”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [140]
Cites
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149 · see citing works
Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
Sofic, E., Riederer, P. F., Heinsen, H., Beckmann, H., Reynolds, G. P., Hebenstreit, G. F., & Youdim, M. B. H. (1988) · Journal of Neural Transmission · doi:10.1007/bf01244786 · Cited by 754 · see citing works
Prospective Study of Caffeine Consumption and Risk of Parkinson’s Disease in Men and Women
Ascherio, A., Zhang, S. M., Hernán, M. A., Kawachi, I., Colditz, G. A., Speizer, F. E., & Willett, W. C. (2001) · Annals of Neurology · doi:10.1002/ana.1052 · Cited by 677 · see citing works
Self-citationGenetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo
Kaur, D., Yantiri, F., Rajagopalan, S., Kumar, J., Mo, J. Q., Boonplueang, R., Viswanath, V., Jacobs, R., Yang, L., Beal, M. F., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00126-0 · Cited by 620 · see citing works
The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity
Golts, N., Petrucelli, L., Hardy, J., Lee, J. M., Farer, M., & Wolozin, B. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06048.2000 · Cited by 544 · see citing works
Connor, J. R., Snyder, B. S., Arosio, P., Loeffler, D. A., & LeWitt, P. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020717.x · Cited by 317 · see citing works
Effect of blood donation on iron stores as evaluated by serum ferritin
Finch, C. A., Cook, J., Labbé, R. F., & Culala, M. (1977) · Blood · doi:10.1182/blood.v50.3.441.441 · Cited by 298 · see citing works
Weight loss in Parkinson's disease
Chen, H., Zhang, S. M., Hernán, M. Á., Willett, W. C., & Ascherio, A. (2003) · Annals of Neurology · doi:10.1002/ana.10577 · Cited by 295 · see citing works
Self-citationFaucheux, B. A., Nillesse, N., Damier, P., Spik, G., Prigent, A., Pierce, A., Leveugle, B., Kubis, N., Hauw, J., & Agid, Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9603 · Cited by 218 · see citing works
Salonen, J. T., Tuomainen, T., Salonen, R., Lakka, T. A., & Nyyssonen, K. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009669 · Cited by 198 · see citing works
Blood Donations and Risk of Coronary Heart Disease in Men
Ascherio, A., Rimm, E. B., Giovannucci, E. L., Willett, W. C., & Stampfer, M. J. (2001) · Circulation · doi:10.1161/01.cir.103.1.52 · Cited by 193 · see citing works
Self-citationForte, G., Bocca, B., Senofonte, O., Petrucci, F., Brusa, L., Stanzione, P., Zannino, S., Violante, N., Alimonti, A., & Sancesario, G. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0124-0 · Cited by 138 · see citing works
Iron uptake and utilization by mammalian cells. I: Cellular uptake of transferrin and iron
Octave, J., Schneider, Y., Trouet, A., & Crichton, R. R. (1983) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(83)90217-7 · Cited by 136 · see citing works
Does cellular iron dysregulation play a causative role in Parkinson’s disease?
Kaur, D., & Andersen, J. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.01.003 · Cited by 123 · see citing works
Altered systemic iron metabolism in Parkinson's disease
Logroscino, G., Marder, K. S., Graziano, J. H., Freyer, G. A., Slavkovich, V. N., LoIacono, N. J., Cote, L. J., & Mayeux, R. P. (1997) · Neurology · doi:10.1212/wnl.49.3.714 · Cited by 118 · see citing works
Self-citationGassen, M., & Youdim, M. B. H. (1997) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1997.tb00390.x · Cited by 77 · see citing works
Role of dietary iron restriction in a mouse model of Parkinson's disease
Levenson, C. W., Cutler, R. G., Ladenheim, B., Cadet, J. L., Hare, J., & Mattson, M. P. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.08.014 · Cited by 64 · see citing works
Gałązka-Friedman, J., Bauminger, E. R., Koziorowski, D., & Friedman, A. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.11.005 · Cited by 49 · see citing works
Cole, G. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00160-0 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 21 references couldn’t be matched to a known paper.
Cited by
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The epidemiology of Parkinson's disease: risk factors and prevention
Ascherio, A., & Schwarzschild, M. A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30230-7 · Cited by 1,837 · see citing works
Self-citationThe role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
Epidemiology and etiology of Parkinson's disease: a review of the evidence
Wirdefeldt, K., Adami, H.-O., Cole, P., Trichopoulos, D., & Mandel, J. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9581-6 · Cited by 1,199 · see citing works
Garza-Lombó, C., Posadas, Y., Quintanar, L., Gonsebatt, M. E., & Franco, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7272 · Cited by 254 · see citing works
Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
Pichler, I., Del Greco M., F., Gögele, M., Lill, C. M., Bertram, L., Do, C. B., Eriksson, N., Foroud, T., Myers, R. H., PD GWAS Consortium, et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001462 · Cited by 173 · see citing works
“A case-control study suggested an increased risk of PD in men who reported multiple recent blood donations and thus experienced depleted systemic iron stores [45], and another study showed an association of anemia experienced early in life with increased PD risk, with the authors hypothesizing that anemia could be a s…”
BackgroundProspective study of plasma urate and risk of Parkinson disease in men and women
Gao, X., O’Reilly, É. J., Schwarzschild, M. A., & Ascherio, A. (2016) · Neurology · doi:10.1212/wnl.0000000000002351 · Cited by 142 · see citing works
Self-citationDisrupted iron homeostasis causes dopaminergic neurodegeneration in mice
Matak, P., Matak, A., Moustafa, S. M., Aryal, D. K., Benner, E. J., Wetsel, W. C., & Andrews, N. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519473113 · Cited by 133 · see citing works
Iron and Oxidative Stress in Parkinson’s Disease: An Observational Study of Injury Biomarkers
Medeiros, M. S., Schumacher-Schuh, A., Cardoso, A. M., Bochi, G. V., Baldissarelli, J., Kegler, A., Santana, D., Chaves, C. M. M. B. S., Schetinger, M. R. C., Moresco, R. N., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0146129 · Cited by 131 · see citing works
Role of iron in neurotoxicity: a cause for concern in the elderly?
Stankiewicz, J., & Brass, S. D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831ba07c · Cited by 94 · see citing works
Biological and Clinical Implications of Comorbidities in Parkinson’s Disease
Santiago, J. A., Bottero, V., & Potashkin, J. A. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00394 · Cited by 95 · see citing works
Dietary Iron Intake and Risk of Parkinson's Disease
Logroscino, G., Gao, X., Chen, H., Wing, A., & Ascherio, A. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn273 · Cited by 93 · see citing works
Self-citationLocascio, J. J., Eberly, S. W., Liao, Z., Liu, G., Hoesing, A. N., Duong, K. T., Lipsanopoulos, A. T. T., Dhima, K., Hung, A. Y., Flaherty, A. W., et al. (2015) · Brain · doi:10.1093/brain/awv202 · Cited by 91 · see citing works
Anemia or low hemoglobin levels preceding Parkinson disease: A case-control study
Savica, R., Grossardt, B. R., Carlin, J. M., Icen, M., Bower, J. H., Ahlskog, J. E., Maraganore, D. M., Steensma, D. P., & Rocca, W. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bd80c1 · Cited by 87 · see citing works
Palacios, N., Fitzgerald, K. C., Roberts, A. L., Hart, J. E., Weisskopf, M. G., Schwarzschild, M. A., Ascherio, A., & Laden, F. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307218 · Cited by 79 · see citing works
Self-citationAge-Related Changes and Sex-Related Differences in Brain Iron Metabolism
Kezele, T. G., & Ćurko‐Cofek, B. (2020) · Nutrients · doi:10.3390/nu12092601 · Cited by 72 · see citing works
Costa‐Mallen, P., Gatenby, C., Friend, S., Maravilla, K. R., Hu, S., Cain, K. C., Agarwal, P., & Anzai, Y. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.04.035 · Cited by 61 · see citing works
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Madenci, G., Bilen, Ş., Arlı, B., Saka, M., & Ak, F. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0729-x · Cited by 53 · see citing works
Deng, Q.-Y., Zhou, X., Chen, J., Pan, M.-Q., Gao, H., Zhou, J., Wang, D.-M., Chen, Q., Zhang, X.-M., Wang, Q., et al. (2017) · Brain Research · doi:10.1016/j.brainres.2016.11.007 · Cited by 48 · see citing works
Correction: Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
Pichler, I., Fabiola Del Greco, M., Gögele, M., Lill, C. M., Bertram, L., Do, C. B., Eriksson, N., Foroud, T., Myers, R. H., Nalls, M. A., et al. (2013) · PLoS Medicine · doi:10.1371/annotation/c4d81646-0c0e-4a3e-9425-b220bae2d8b6 · Cited by 46 · see citing works
The conundrum of iron in multiple sclerosis – time for an individualised approach
van Rensburg, S. J., Kotze, M. J., & van Toorn, R. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9290-1 · Cited by 45 · see citing works
Santiago, J. A., & Potashkin, J. A. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00073 · Cited by 32 · see citing works
Serum Iron and Ferritin Level in Idiopathic Parkinson
Farhoudi, M., Taheraghda, A., Farid, G. A., Talebi, M., Pashapou, A., Majidi, J., & Goldust, M. (2012) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2012.1094.1097 · Cited by 31 · see citing works
Haptoglobin Phenotype Modifies Serum Iron Levels and the Effect of Smoking on Parkinson Disease Risk
Costa-Mallen, P., Zabetian, C., Agarwal, P., Hu, S.-C., Yearout, D., Samii, A., Leverenz, J., Roberts, J., & Checkoway, H. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.07.006 · Cited by 34 · see citing works
Wu, L., Gong, W., Shen, S., Wang, Z., Yao, J., Wang, J., Yu, J., Gao, R., & Wu, G. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.04.112 · Cited by 24 · see citing works
Nigrostriatal iron accumulation in the progression of Parkinson’s disease
López‐Aguirre, M., Balzano, T., Monje, M. H. G., Esteban-García, N., Martínez‐Fernández, R., del Rey, N. L., Ciorraga, M., Sánchez‐Ferro, Á., Trigo‐Damas, I., Blesa, J., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-00911-6 · Cited by 22 · see citing works
Shen, X., Yang, H., Zhang, D., & Jiang, H. F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00939 · Cited by 21 · see citing works
Anemia in men and increased Parkinson's disease risk: A population-based large scale cohort study
Rozani, V., Giladi, N., Gurevich, T., El‐Ad, B., Tsamir, J., Hemo, B., & Peretz, C. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.03.010 · Cited by 17 · see citing works
Kim, J. H., Oh, J., Wee, J., Min, C., Yoo, D., & Choi, H. (2021) · Brain Science · doi:10.3390/brainsci11050623 · Cited by 13 · see citing works
Risk of illness, hospitalization and death in a cohort of blood donors in Italy
Gallerani, M., Volpato, S., Cellini, M., Reverberi, R., Mikhailidis, D. P., & Manfredini, R. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.921146 · Cited by 11 · see citing works
Sympathetic nervous activity and hemoglobin levels in de novo Parkinson’s disease
Umehara, T., Oka, H., Nakahara, A., Shiraishi, T., Sato, T., Matsuno, H., Komatsu, T., Omoto, S., Murakami, H., & Iguchi, Y. (2020) · Clinical Autonomic Research · doi:10.1007/s10286-020-00668-3 · Cited by 10 · see citing works
Dietary Factors Affect Brain Iron Accumulation and Parkinson’s Disease RiskPreprint
Ahern, J., Boyle, M., Sugrue, L., Andreassen, O., Dale, A., Thompson, W. K., Fan, C.-C., & Loughnan, R. (2024) · medRxiv · doi:10.1101/2024.03.13.24304253 · Cited by 3 · see citing works
Hemochromatosis neural archetype reveals iron disruption in motor circuits
Loughnan, R. J., Ahern, J., Boyle, M. E. T., Jernigan, T. L., Hagler, D. J., Iversen, J. R., Frei, O., Smith, D. M. Y., Andreassen, O. A., Zaitlen, N., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp4431 · Cited by 6 · see citing works
Four Cases of Parkinson Disease Diagnosed During the Postpartum Period
Maltête, D., Grangeon, L., Goff, F. L., Özel, G., Fetter, D., Ahtoy, P., Temgoua, O., Rouillé, A., & Lefaucheur, R. (2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002066 · Cited by 6 · see citing works
Comorbidities in patients with Parkinson's disease
Caldarov, A., Gavriliuc, O., Rotaru, L., Andrușca, A., Fala, P., & Gavriliuc, M. (2022) · Bulletin of the Academy of Sciences of Moldova Medical Sciences · doi:10.52692/1857-0011.2021.3-71.25 · Cited by 2 · see citing works
Chen, H., Xie, W., Chang, Z., Zhang, J., & Xie, D. (2024) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2024.127430 · Cited by 2 · see citing works
Self-citationZuo, C., Hao, X., Li, M.-J., Guo, M., Ma, D., Li, S., Liang, Y., Hao, C., Wang, Z., Feng, Y., et al. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.107153 · Cited by 1 · see citing works
Environmental Factors and Parkinson's Disease
Tanner, C. M. (2009) · Blue books of neurology · doi:10.1016/b978-1-4160-6641-5.00008-8 · Cited by 1 · see citing works
EARLY RECOGNITION OF COGNITIVE ABILITY AND NUTRITIONAL MARKERS FOR DEMENTIA IN PARKINSON’S DISEASE
Håglin, L., Bäckman, L., Linder, J., Forsgren, L., & Domellöf, M. (2018) · Journal of Aging Research and Lifestyle · doi:10.14283/jarcp.2018.26
- Authors
- Logroscino, G., Chen, H., Wing, A., & Ascherio, A.
- Affiliations
- Harvard University (US)
- National Institutes of Health (US)
- Corresponding author
- Logroscino, Giancarlo
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2006-06-06
- Volume
- 21
- Issue
- 6
- Pages
- 835-838
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2010167929
- Cited by
- 38
- References
- 21
- Citations by year
- 2025: 1 · 2024: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- Parkinson's disease, blood donation, iron overload, ferritin, disease risk, men
- MeSH terms
- Adult, Aged, Blood Donors, Humans, Iron, Male, Middle Aged, Parkinson Disease, Physicians, Surveys and Questionnaires, Risk, Risk Factors, United States, Iron Overload
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