Dietary Iron Intake and Risk of Parkinson's Disease
Open accessAbstract
Dietary iron is the most important source of iron stores. Several case-control studies have described the association of high dietary iron and Parkinson's disease, but prospective data are lacking. The authors prospectively followed 47,406 men and 76,947 women from the United States who provided information through a mailed questionnaire on their diet, medical history, and lifestyle practices between 1984 and 2000. The authors documented 422 new cases of Parkinson's disease. Total iron intake was not associated with an increased risk of Parkinson's disease (relative risk (RR) = 1.10, 95% confidence interval (CI): 0.74, 1.65; P(trend) = 0.84), but dietary nonheme iron intake from food was associated with a 30% increased risk of Parkinson's disease (RR = 1.27, 95% CI: 0.92, 1.76; P(trend) = 0.02). A secondary analysis revealed that Parkinson's disease risk was significantly increased among individuals with high nonheme iron and low vitamin C intakes (RR = 1.92, 95% CI: 1.14, 3.32; P(trend) = 0.002). Supplemental iron intake was associated with a borderline increase in Parkinson's disease risk among men. Although the authors' prospective data did not support an association between total iron intake (dietary and supplemental) and risk of Parkinson's disease, a 30% increased risk was associated with a diet rich in nonheme iron. This increase in risk was present in those who had low vitamin C intake.
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Iron not only induces oxidative stress but damages proteins, membranes, and nucleic acids and eventually leads to dopaminergic neuron death in the substantia nigra.
“Iron not only induces oxidative stress but damages proteins, membranes, and nucleic acids and eventually leads dopaminergic neuron death in the substantia nigra (Logroscino et al., 2008).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Logroscino et al., 2008
Brain iron is responsive to peripheral iron status, hence brain iron status can be modulated by the iron content of the diet, both restriction and supplementation.
“Logroscino et al., (2008) stated that brain iron is responsive to peripheral iron status, hence brain iron status can be modulated by the iron content of the diet, both restriction and supplementation.”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Logroscino et al., (2008)
Even a modest increase in the iron concentration in the substantia nigra may increase oxidative stress and neurodegeneration.
“Even a modest increase in the iron concentration in the substantia nigra may increase oxidative stress and neurodegeneration (Logroscino et al., 2008).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Logroscino et al., 2008
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Epidemiology and etiology of Parkinson's disease: a review of the evidence
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The application of Ferroptosis in diseases
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Iron, Oxidative Stress and Health
Udipi, S., Ghugre, P., & Gokhale, C. (2012) · Oxidative Stress - Molecular Mechanisms and Biological Effects · doi:10.5772/34975 · Cited by 17 · see citing works
- Authors
- Logroscino, G., Gao, X., Chen, H., Wing, A., & Ascherio, A.
- Affiliations
- University of Bari Aldo Moro (IT)
- Penn State Cancer Institute (US)
- National Institutes of Health (US)
- Harvard University (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-22
- Volume
- 168
- Issue
- 12
- Pages
- 1381-1388
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC2727188
- OpenAlex
- W2140988251
- Cited by
- 93
- References
- 8
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 2 · 2012: 4
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- Michael J. Fox Foundation for Parkinson's Research
- Brigham and Women's Hospital
- Kinetics Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS035624)
- National Institute of Environmental Health Sciences
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- Parkinson's disease, dietary iron, non-heme iron, vitamin C intake, iron intake, disease risk, prospective cohort
- MeSH terms
- Adult, Age Factors, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Morbidity, Parkinson Disease, Prospective Studies, Surveys and Questionnaires, Risk Factors, Sex Factors, United States, Confidence Intervals, Odds Ratio, Iron, Dietary, Dietary Supplements
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