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Cited by 177Gastrointestinal motility and disordersParkinson's Disease Mechanisms and TreatmentsPelvic floor disorders treatments

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Macrogol for the treatment of constipation in Parkinson’s disease. A randomized placebo-controlled study

Zangaglia, Roberta, Martignoni, Emilia, Glorioso, Margaret, Ossola, Maria, Riboldazzi, Giulio, Calandrella, Daniela, Brunetti, Gabriele, Pacchetti, Claudio·2007·Movement Disorders
DOI 10.1002/mds.21243
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Abstract

Chronic constipation is the most frequent symptom of autonomic system involvement in Parkinson's disease (PD). Quite often the symptom is severe and impairs patients' quality of life. The objective of this study is to determine the efficacy and safety of an isosmotic macrogol solution for the treatment of constipation in PD patients, in a double-blind, placebo-controlled study. A total of 57 PD patients with constipation were randomly assigned to receive an isosmotic macrogol electrolyte solution (MC-ES; 29 patients) or placebo (28 patients) for 8 weeks. Treatment efficacy was defined as complete relief of the symptom or a marked improvement of two of the following indicators: stool frequency, straining, stool consistency, use of rectal laxatives as a rescue therapy. The responder rates were significantly higher in the MC-ES group both at the first (4 weeks; P < 0.0003) and at the final evaluation (8 weeks; P < 0.0012). The frequency of bowel movements (P < 0.002) and stool consistency (P < 0.006) were significantly changed in the MC-ES group compared to the placebo group. At the final evaluation, a rectal laxative was used by 2 (12.5%) patients on placebo, whereas no use was recorded in the MC-ES group. Responder rate for straining showed a favorable trend in patients treated with macrogol versus placebo. Unified Parkinson's Disease Rating Scale Part III and Parkinson's Disease Questionnaire (PDQ-39) did not show any significant modification in either group during the 8-week…

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Crossref · 10.1002/mds.21243

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Research works printed but not linked: 2

  1. Parkinson J, 1817, An essay on the shaking palsy
  2. Wiesel PH, 2001, Management of faecal incontinence and constipation in adults with central neurological disease, Cochrane Database Syst Rev, 2

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Metadata

Authors
Zangaglia, R., Martignoni, E., Glorioso, M., Ossola, M., Riboldazzi, G., Calandrella, D., Brunetti, G., & Pacchetti, C.
Affiliations
  • Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IT)
  • Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
  • University of Insubria (IT)
Corresponding author
Zangaglia, Roberta
ORCID
Venue
Movement Disorders
Publisher
Wiley
Published
2007-06-12
Volume
22
Issue
9
Pages
1239-1244
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
DOI
10.1002/mds.21243
OpenAlex
W1966941681
Cited by
177
References
34
Citations by year
2026: 7 · 2025: 12 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 6 · 2016: 14 · 2015: 14 · 2014: 5 · 2013: 15 · 2012: 10
FWCI
7.18
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Movement Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
Keywords
Parkinson's disease, constipation, macrogol, polyethylene glycol electrolyte solution, autonomic dysfunction, stool frequency, stool consistency, straining, treatment efficacy and safety
MeSH terms
Aged, Constipation, Double-Blind Method, Female, Humans, Male, Parkinson Disease, Polyethylene Glycols, Severity of Illness Index, Surface-Active Agents, Time Factors, Chi-Square Distribution

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