The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Macrogol for the treatment of constipation in Parkinson’s disease. A randomized placebo-controlled study
Abstract
Chronic constipation is the most frequent symptom of autonomic system involvement in Parkinson's disease (PD). Quite often the symptom is severe and impairs patients' quality of life. The objective of this study is to determine the efficacy and safety of an isosmotic macrogol solution for the treatment of constipation in PD patients, in a double-blind, placebo-controlled study. A total of 57 PD patients with constipation were randomly assigned to receive an isosmotic macrogol electrolyte solution (MC-ES; 29 patients) or placebo (28 patients) for 8 weeks. Treatment efficacy was defined as complete relief of the symptom or a marked improvement of two of the following indicators: stool frequency, straining, stool consistency, use of rectal laxatives as a rescue therapy. The responder rates were significantly higher in the MC-ES group both at the first (4 weeks; P < 0.0003) and at the final evaluation (8 weeks; P < 0.0012). The frequency of bowel movements (P < 0.002) and stool consistency (P < 0.006) were significantly changed in the MC-ES group compared to the placebo group. At the final evaluation, a rectal laxative was used by 2 (12.5%) patients on placebo, whereas no use was recorded in the MC-ES group. Responder rate for straining showed a favorable trend in patients treated with macrogol versus placebo. Unified Parkinson's Disease Rating Scale Part III and Parkinson's Disease Questionnaire (PDQ-39) did not show any significant modification in either group during the 8-week…
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“Randomized controlled trials have demonstrated benefit of polyethylene glycol 3350 (Zangaglia et al., 2007) and lubiprostone (Ondo et al., 2012) in PD-related constipation, and dopaminergic agents such as apomorphine can influence defecatory function (Edwards et al., 1993b).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Zangaglia et al., 2007
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Seppi, K., Weintraub, D., Coelho, M., Perez‐Lloret, S., Fox, S. H., Katzenschlager, R., Hametner, E., Poewe, W., Rascol, O., Goetz, C. G., et al. (2011) · Movement Disorders · doi:10.1002/mds.23884 · Cited by 1,141
Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT
Barichella, M., Pacchetti, C., Bolliri, C., Cassani, E., Iorio, L., Pusani, C., Pinelli, G., Privitera, G., Cesari, I., Faierman, S. A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003127 · Cited by 390
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Ferreira, J. J., Katzenschlager, R., Bloem, B. R., Bonuccelli, U., Burn, D. J., Deuschl, G., Dietrichs, E., Fabbrini, G., Friedman, A., Kaňovský, P., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03866.x · Cited by 359
New evidence on the management of Lewy body dementia
Taylor, J.-P., McKeith, I. G., Burn, D. J., Boeve, B. F., Weintraub, D., Bamford, C., Allan, L. M., Thomas, A. J., & O'Brien, J. T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30153-x · Cited by 347
Metadata
- Authors
- Zangaglia, R., Martignoni, E., Glorioso, M., Ossola, M., Riboldazzi, G., Calandrella, D., Brunetti, G., & Pacchetti, C.
- Affiliations
- Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Insubria (IT)
- Corresponding author
- Zangaglia, Roberta
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2007-06-12
- Volume
- 22
- Issue
- 9
- Pages
- 1239-1244
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W1966941681
- Cited by
- 177
- References
- 34
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 6 · 2016: 14 · 2015: 14 · 2014: 5 · 2013: 15 · 2012: 10
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
- Keywords
- Parkinson's disease, constipation, macrogol, polyethylene glycol electrolyte solution, autonomic dysfunction, stool frequency, stool consistency, straining, treatment efficacy and safety
- MeSH terms
- Aged, Constipation, Double-Blind Method, Female, Humans, Male, Parkinson Disease, Polyethylene Glycols, Severity of Illness Index, Surface-Active Agents, Time Factors, Chi-Square Distribution
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