New evidence on the management of Lewy body dementia
Open accessAbstract
Dementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy body dementia present with a wide range of cognitive, neuropsychiatric, sleep, motor, and autonomic symptoms. Presentation varies between patients and can vary over time within an individual. Treatments can address one symptom but worsen another, which makes disease management difficult. Symptoms are often managed in isolation and by different specialists, which makes high-quality care difficult to accomplish. Clinical trials and meta-analyses now provide an evidence base for the treatment of cognitive, neuropsychiatric, and motor symptoms in patients with Lewy body dementia. Furthermore, consensus opinion from experts supports the application of treatments for related conditions, such as Parkinson's disease, for the management of common symptoms (eg, autonomic dysfunction) in patients with Lewy body dementia. However, evidence gaps remain and future clinical trials need to focus on the treatment of symptoms specific to patients with Lewy body dementia.
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A narrative review and a Delphi consensus group supported donepezil and rivastigmine for neuropsychiatric symptoms of dementia with Lewy bodies, although a network meta-analysis found these drugs improved neuropsychiatric symptoms in Parkinson's disease dementia but not in dementia with Lewy bodies.
“A narrative review 124 and a Delphi consensus group 125 supported the use of donepezil and rivastigmine for neuropsychiatric symptoms of dementia with Lewy bodies, although a network meta‐analysis found that these drugs improved neuropsychiatric symptoms in Parkinson's disease dementia, but not in dementia with Lewy bodies 123 .”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [125]
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Research works printed but not linked: 1
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Visual hallucinations in Parkinson’s disease: spotlight on central cholinergic dysfunction
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Lewy body dementia: overcoming barriers and identifying solutions
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- Authors
- Taylor, J.-P., McKeith, I. G., Burn, D. J., Boeve, B. F., Weintraub, D., Bamford, C., Allan, L. M., Thomas, A. J., & O'Brien, J. T.
- Affiliations
- Newcastle University (GB)
- Mental Illness Research, Education and Clinical Centers (US)
- University of Exeter (GB)
- University of Cambridge (GB)
- Corresponding author
- Taylor, John-Paul
- ORCID
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 19
- Issue
- 2
- Pages
- 157-169
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC7017451
- OpenAlex
- W2951808807
- Cited by
- 347
- References
- 120
- Citations by year
- 2026: 29 · 2025: 75 · 2024: 61 · 2023: 56 · 2022: 51 · 2021: 47 · 2020: 24 · 2019: 2 · 2018: 1
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion, cc-by-nc-nd)
- Figshare (submittedVersion, cc-by-nc-nd)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
- Funders
- National Institute for Health and Care Research (DTC-RP-PG-0311-12001, NF-SI-0611-10048)
- National Institute on Aging (U19AG062418)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- dementia with Lewy bodies, Parkinson's disease dementia, dementia management, cognitive symptoms, neuropsychiatric symptoms, motor symptoms, autonomic dysfunction, sleep symptoms, symptom management, multidisciplinary care
- MeSH terms
- Dementia, Humans, Parkinson Disease, Lewy Bodies, Neurodegenerative Diseases, Lewy Body Disease
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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