Defining mild cognitive impairment in Parkinson's disease
Abstract
Our purpose was to characterize a state of mild cognitive impairment (MCI) in Parkinson's disease (PD) (PD‐MCI) that would be analogous to the MCI that is posited as a precursor of Alzheimer's disease (AD). We categorized 86 PD subjects in a brain bank population as either cognitively normal (PD‐CogNL), PD‐MCI using criteria that included a 1.5 standard deviation or greater deficit upon neuropsychological testing consistently across at least one cognitive domain without dementia, and PD dementia (PD‐D) using DSM‐IV criteria. Twenty‐one percent of our PD sample met criteria for PD‐MCI, 62% were PD‐CogNL, and 17% had PD‐D. The mean duration of PD and MMSE scores of the PD‐MCI group were intermediate and significantly different from both PD‐CogNL and PD‐D. The cognitive domain most frequently abnormal in PD‐MCI was frontal/executive dysfunction followed by amnestic deficit. Single domain PD‐MCI was more common than PD‐MCI involving multiple domains. We conclude that a stage of clinical cognitive impairment in PD exists between PD‐CogNL and PD‐D, and it may be defined by applying criteria similar to the MCI that is posited as a precursor of AD. Defining PD‐MCI offers an opportunity for further study of cognitive impairment in PD and targets for earlier therapeutic intervention. © 2007 Movement Disorder Society
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Cognitive impairment can be relatively mild in depression.
“The observed impairment can be profound, as in Alzheimer's disease or Parkinson's disease (PD), or relatively mild, as in depression (Brown & Marsden, 1990; Caviness et al., 2007; Douglas et al., 2018; Petersen et al., 2001).”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Caviness et al., 2007
Impairments may affect multiple cognitive domains, including information processing, working memory, executive functioning and attention.
“Impairments may affect multiple cognitive domains, including information processing, working memory, executive functioning and attention (Caviness et al., 2007; Higuchi et al., 2017; Maloni, 2018).”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Caviness et al., 2007
Cognitive impairment can be profound in Alzheimer's disease or Parkinson's disease.
“The observed impairment can be profound, as in Alzheimer's disease or Parkinson's disease (PD), or relatively mild, as in depression (Brown & Marsden, 1990; Caviness et al., 2007; Douglas et al., 2018; Petersen et al., 2001).”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Caviness et al., 2007
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Cognitive impairment in incident, untreated Parkinson disease: The Norwegian ParkWest Study
Aarsland, D., Brønnick, K., Larsen, J. P., Tysnes, O. B., & Alves, G. (2009) · Neurology · doi:10.1212/01.wnl.0000338632.00552.cb · Cited by 625 · see citing works
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Cortical phosphorylated α‐Synuclein levels correlate with brain wave spectra in Parkinson's disease
Caviness, J. N., Lue, L., Hentz, J. G., Schmitz, C. T., Adler, C. H., Shill, H. A., Sabbagh, M. N., Beach, T. G., & Walker, D. G. (2016) · Movement Disorders · doi:10.1002/mds.26621 · Cited by 37 · see citing works
Self-citation
- Authors
- Caviness, J. N., Driver‐Dunckley, E., Connor, D. J., Sabbagh, M. N., Hentz, J. G., Noble, B., Evidente, V. G. H., Shill, H. A., & Adler, C. H.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Caviness, John N.
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2007-04-05
- Volume
- 22
- Issue
- 9
- Pages
- 1272-1277
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W1985118959
- Cited by
- 422
- References
- 5
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 9 · 2022: 15 · 2021: 17 · 2020: 11 · 2019: 23 · 2018: 13 · 2017: 22 · 2016: 25 · 2015: 26 · 2014: 36 · 2013: 41 · 2012: 48
- FWCI
- 15.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P30AG019610)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Parkinson's disease, mild cognitive impairment, Parkinson's disease dementia, executive dysfunction, brain banks, neuropsychological assessment, disease duration
- MeSH terms
- Aged, Aged, 80 and over, Cognition Disorders, Dementia, Female, Humans, Male, Motor Activity, Neuropsychological Tests, Parkinson Disease, Retrospective Studies, Chi-Square Distribution
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