A rizona S tudy of A ging and N eurodegenerative D isorders and B rain and B ody D onation P rogram
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The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain-only donations and currently has banked more than 1600 brains. More than 430 whole-body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also directed at subjects with Alzheimer's disease, Parkinson's disease and cancer. The median age at death is 82. Subjects receive standardized general medical, neurological, neuropsychological and movement disorders assessments during life and more than 90% receive full pathological examinations by medically licensed pathologists after death. The Program has been funded through a combination of internal, federal and state of Arizona grants as well as user fees and pharmaceutical industry collaborations. Subsets of the Program are utilized by the US National Institute on Aging Arizona Alzheimer's Disease Core Center and the US National Institute of Neurological Disorders and Stroke National Brain and Tissue Resource for Parkinson's Disease and Related Disorders. Substantial funding has also been received from the Michael J. Fox Foundation for Parkinson's Research. The Program has made rapid autopsy a priority, with a 3.0-hour median post-mortem interval for the entire collection. The median RNA Integrity Number (RIN) for frozen brain and body tissue is 8.9 and 7.4, respectively. More than 2500 tissue requests have been served and currently about 200 are served annually. These requests have been made by more than 400 investigators located in 32 US states and 15 countries. Tissue from the BBDP has contributed to more than 350 publications and more than 200 grant-funded projects.
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The acquisition of rich proteomic information is largely attributed to access to high quality AD brain tissue and the strength of the optimized MS-based proteomics platform.
“The acquisition of such rich proteomic information is largely attributed to the access to high quality AD brain tissue (Beach et al., 2015) and the strength of the optimized mass spectrometry-based proteomics platform, including multiplex TMT isobaric labeling (Niu et al., 2017), extensive long gradient LC/LC coupled with high resolution MS/MS analysis (Wang et al., 2015), a refined phosphopeptide”
From Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression (2020) · cites this paper as Beach et al., 2015
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Self-citationBoth early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease
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Self-citationPreventing Activation of Receptor for Advanced Glycation Endproducts in Alzheimers Disease
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Self-citationThe influence of agonal status on some neurochemical activities of postmortem human brain tissue
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Relation of Coronary Atherosclerosis and Apolipoprotein E Genotypes in Alzheimer Patients
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Self-citationCardiovascular Disease Risk Factors and Cognitive Impairment
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Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation
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Self-citationOligomerization and fibril assembly of the amyloid-β protein
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- [288]Beach TG Sue LI Walker DG Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits Acta Neuropathol 2007 114 419 424 17639428
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BackgroundMethodInfluentialSelf-citationAlzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
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Self-citation
- Authors
- Beach, T. G., Adler, C. H., Sue, L. I., Serrano, G., Shill, H. A., Walker, D. G., Lue, L., Roher, A. E., Dugger, B. N., Maarouf, C., Birdsill, A. C., Intorcia, A., Saxon‐Labelle, M., Pullen, J., Scroggins, A., Filon, J., Scott, S., Hoffman, B., Garcia, A., Caviness, J. N., Hentz, J. G., Driver‐Dunckley, E., Jacobson, S. A., Davis, K. J., Belden, C. M., Long, K. E., Malek‐Ahmadi, M., Powell, J. J., Gale, L. D., Nicholson, L. R., Caselli, R. J., Woodruff, B. K., Rapscak, S. Z., Ahern, G. L., Shi, J., Burke, A. D., Reiman, E. M., & Sabbagh, M. N.
- Affiliations
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Arizona (US)
- Banner Sun Health Research Institute Sun City Arizona USA
- University of Arizona (US)
- Barrow Neurological Institute (US)
- Banner Alzheimer’s Institute (US)
- Corresponding author
- Beach, Thomas G.
- ORCID
- Beach, Thomas G.
- Adler, Charles H.
- Serrano, Geidy
- Shill, Holly A.
- Walker, Douglas G.
- Dugger, Brittany N.
- Birdsill, Alex C.
- Hentz, Joseph G.
- Driver‐Dunckley, Erika
- Jacobson, Sandra A.
- Belden, Christine M.
- Malek‐Ahmadi, Michael
- Caselli, Richard J.
- Woodruff, Bryan K.
- Shi, Jiong
- Burke, Anna D.
- Reiman, Eric M.
- Sabbagh, Marwan N.
- Venue
- Neuropathology
- Publisher
- Wiley
- Published
- 2015-01-26
- Volume
- 35
- Issue
- 4
- Pages
- 354-389
- ISSN
- 0919-6544 (ISSN-L)
- 1440-1789
- PMC
- PMC4593391
- OpenAlex
- W2161031490
- Cited by
- 460
- References
- 347
- Citations by year
- 2026: 41 · 2025: 56 · 2024: 68 · 2023: 49 · 2022: 53 · 2021: 44 · 2020: 42 · 2019: 29 · 2018: 24 · 2017: 25 · 2016: 19 · 2015: 10
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (U24 NS072026)
- National Institute on Aging (P30 AG19610)
- Michael J. Fox Foundation for Parkinson's Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- brain donation, body donation, autopsy, Alzheimer's disease, Parkinson's disease, cancer, tissue banking, RNA integrity, postmortem interval, research funding
- MeSH terms
- Aged, 80 and over, Aging, Arizona, Autopsy, Brain, Female, Humans, Male, Organ Preservation, Tissue and Organ Procurement, Postmortem Changes, Tissue Banks, Tissue Donors, Tissue Survival, Biomarkers, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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