Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study
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Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first-degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD.
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Occurrence of non-motor symptoms in otherwise healthy people is associated with an increased risk of developing Parkinson's disease.
“their occurrence in otherwise healthy people has been associated with an increased risk of developing PD (Abbott et al., 2001;Ponsen et al., 2009).”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Ponsen et al., 2009
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- Authors
- Ponsen, M. M., Stoffers, D., Twisk, J. W. R., Wolters, E. C., & Berendse, H. W.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Ponsen, Mirthe M.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2009-05-15
- Volume
- 24
- Issue
- 7
- Pages
- 1060-1065
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W1825812391
- Cited by
- 127
- References
- 28
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 15 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 10 · 2012: 9
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- green
- research.vumc.nl
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (acceptedVersion)
- VU Research Portal (acceptedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, hyposmia, olfactory dysfunction, executive dysfunction, odor discrimination, first-degree relatives, early detection, predictive biomarkers
- MeSH terms
- Aged, Olfaction Disorders, Cognition Disorders, Family Health, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Parkinson Disease, Predictive Value of Tests, Problem Solving, Regression Analysis
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