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Cited by 838Olfactory and Sensory Function StudiesParkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Olfactory dysfunction in parkinsonism: A general deficit unrelated to neurologic signs, disease stage, or disease duration

Doty, Richard L., Deems, Daniel A., Stellar, Stanley·1988·Neurology
DOI 10.1212/wnl.38.8.1237
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Abstract

To explore the nature of the olfactory dysfunction associated with Parkinson's disease (PD), 81 PD patients who scored well on a cognitive screening test were administered the 40-odorant University of Pennsylvania Smell Identification Test; 38 were additionally given a forced-choice phenylethyl alcohol odor detection threshold test. Clinical ratings of 11 neurologic symptoms (three bilateral) were obtained at the time of testing, and odor identification was retested in 24 patients at intervals ranging from 5 to 39 months. Relative to matched controls, the PD patients exhibited consistent and marked decrements on both types of olfactory tests (ps less than 0.0001). The odor identification deficit was not restricted to any subset of odorants and did not evidence longitudinal change. A factor analysis of the intercorrelations among the variables yielded six easily interpretable factors: general motor, oral motor, olfactory function, cognitive function, tremor, and gender. Olfactory test scores were independent of all other measures, including disease stage and duration. Seventy-two percent of the PD patients were unaware of a smell disorder before testing; those who were aware had significantly lower test scores. A statistical comparison of PD patients' olfactory test scores to those obtained from Alzheimer's disease patients found the olfactory disorders of these diseases to be indistinguishable. The data support the hypothesis that the olfactory deficit of PD is a general and…

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  • Reduced or lost sense of smell often appears long before the motor symptoms in Parkinson's disease.

    “Reduced or lost sense of smell is found in at least 80% of patients and this often appears long before the motor symptoms (Doty et al. 1988).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Doty et al. 1988

  • Reduced or lost sense of smell is found in at least 80% of Parkinson's disease patients.

    “Reduced or lost sense of smell is found in at least 80% of patients and this often appears long before the motor symptoms (Doty et al. 1988).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Doty et al. 1988

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Authors
Doty, R. L., Deems, D. A., & Stellar, S.
Affiliations
University of Pennsylvania (US)
ORCID
Doty, Richard L.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1988-08
Volume
38
Issue
8
Pages
1237-1237
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.38.8.1237
OpenAlex
W2008119714
Cited by
838
References
0
Citations by year
2026: 10 · 2025: 19 · 2024: 35 · 2023: 22 · 2022: 30 · 2021: 31 · 2020: 39 · 2019: 43 · 2018: 39 · 2017: 28 · 2016: 25 · 2015: 32 · 2014: 31 · 2013: 30 · 2012: 31
FWCI
6.53
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS 16365)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Parkinson's disease, olfactory dysfunction, odor identification, odor detection threshold, 2-phenylethanol, UPSIT, Alzheimer's disease comparison, early disease detection
MeSH terms
Aged, Female, Humans, Male, Middle Aged, Parkinson Disease, Smell

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