Cognitive function in Parkinson's disease: From description to theory
Abstract
From the large body of empirical evidence on cognitive function in Parkinson's disease, a number of attempts have been made to describe the characteristics of the deficits and the conditions under which they are observed. This review considers descriptions limited to specific domains of cognition such as visuospatial function, memory and 'frontal' function, and more general descriptions relating to 'set-shifting', sequencing, temporal ordering and recency discrimination, the locus of cognitive control and bradyphrenia. Later in the paper an attempt is made to provide some theoretical framework for the various descriptions. Two theories are discussed representing contrasting, but complementary approaches. The first is a 'psychological' theory in which the concept of depleted processing resources is suggested as a possible mechanism to explain the observable deficits. The second is a neurobiological model that attempts to integrate information from diverse sources to provide a model for the neuroanatomical and neurochemical substrate that may underlie some of the behavioural deficits.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cognitive impairment can be profound in Alzheimer's disease or Parkinson's disease.
“The observed impairment can be profound, as in Alzheimer's disease or Parkinson's disease (PD), or relatively mild, as in depression (Brown & Marsden, 1990; Caviness et al., 2007; Douglas et al., 2018; Petersen et al., 2001).”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Brown & Marsden, 1990
Cognitive impairment can be relatively mild in depression.
“The observed impairment can be profound, as in Alzheimer's disease or Parkinson's disease (PD), or relatively mild, as in depression (Brown & Marsden, 1990; Caviness et al., 2007; Douglas et al., 2018; Petersen et al., 2001).”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Brown & Marsden, 1990
Cites
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
Multiple dopamine functions at different time courses
Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415 · see citing works
Dopamine and the regulation of cognition and attention
Nieoullon, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00011-4 · Cited by 1,131 · see citing works
Interactions between frontal cortex and basal ganglia in working memory: A computational model
FRANK, M. J., LOUGHRY, B., & O'REILLY, R. C. (2001) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.1.2.137 · Cited by 879 · see citing works
The neural substrates of reward processing in humans: the modern role of FMRI
McClure, S. M., York, M. K., & Montague, P. R. (2004) · The Neuroscientist · doi:10.1177/1073858404263526 · Cited by 480 · see citing works
Frank, M. J., & O'Reilly, R. C. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.3.497 · Cited by 472 · see citing works
Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI
Werring, D. J. (2004) · Brain · doi:10.1093/brain/awh253 · Cited by 421 · see citing works
Begemann, M. J., Brand, B. A., Ćurčić-Blake, B., Aleman, A., & Sommer, I. E. (2020) · Psychological Medicine · doi:10.1017/s0033291720003670 · Cited by 368 · see citing works
Bodis-Wollner, I. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90113-o · Cited by 296 · see citing works
Basal Ganglia Circuits for Reward Value–Guided Behavior
Hikosaka, O., Kim, H. F., Yasuda, M., & Yamamoto, S. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-013924 · Cited by 259 · see citing works
Frank, M. J., Santamaria, A., O'Reilly, R. C., & Willcutt, E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301278 · Cited by 227 · see citing works
Verbal fluency in dementia of frontal lobe type and dementia of alzheimer type
Pasquier, F., Lebert, F., Grymonprez, L., & Petit, H. (1995) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.1.81 · Cited by 156 · see citing works
Decreased driving ability in people with Parkinson's disease
Heikkila, V.-M., Turkka, J., Korpelainen, J., Kallanranta, T., & Summala, H. (1998) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.3.325 · Cited by 155 · see citing works
Mentis, M. J., McIntosh, A. R., Perrine, K., Dhawan, V., Berlin, B., Feigin, A., Edwards, C., Mattis, P., & Eidelberg, D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.746 · Cited by 136 · see citing works
A systematic review of impulse control disorders in Parkinson’s disease.
Callesen, M. B., Scheel-Krüger, J., Kringelbach, M. L., & Møller, A. (2013) · Journal of Parkinson s Disease · doi:10.3233/jpd-120165 · Cited by 130 · see citing works
Responses of monkey midbrain dopamine neurons during delayed alternation performance
Ljungberg, T., Apicella, P., & Schultz, W. (1991) · Brain Research · doi:10.1016/0006-8993(91)90816-e · Cited by 128 · see citing works
Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study
Ponsen, M. M., Stoffers, D., Twisk, J. W. R., Wolters, E. C., & Berendse, H. W. (2009) · Movement Disorders · doi:10.1002/mds.22534 · Cited by 127 · see citing works
The human striatum is necessary for responding to changes in stimulus relevance.
Cools, R., Ivry, R. B., & D'Esposito, M. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.12.1973 · Cited by 122 · see citing works
Habitual versus goal-directed action control in Parkinson disease
de Wit, S., Barker, R. A., Dickinson, A. D., & Cools, R. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21514 · Cited by 116 · see citing works
The recognition of facial emotion expressions in Parkinson's disease
Assogna, F., Pontieri, F. E., Caltagirone, C., & Spalletta, G. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.07.004 · Cited by 109 · see citing works
- Authors
- Brown, R. G., & Marsden, C. D.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- ORCID
- Brown, R.G.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 13
- Issue
- 1
- Pages
- 21-29
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2065226845
- Cited by
- 475
- References
- 1
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 13
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- Parkinson's disease, cognitive impairment, visuospatial ability, memory, frontal lobe function, set-shifting, sequencing, temporal order, cognitive control, bradyphrenia, neurobiological model, neuroanatomical substrates
- MeSH terms
- Caudate Nucleus, Cognition, Frontal Lobe, Humans, Memory, Models, Biological, Parkinson Disease, Visual Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
