Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease?
Abstract
Evidence suggests that both motor and nonmotor symptoms contribute to health status in Parkinson's disease. Less clear is how much change in health status can be expected if these clinical variables change. In addition, anxiety, separate from depression, has rarely been examined as a predictor of health status. We used hierarchical multiple regression analysis and standardized beta coefficients in a prevalent cohort of 462 patients with Parkinson's disease to explore the relative impact on health status (measured using the Parkinson's Disease Questionnaire) of 5 well‐recognized symptom domains in Parkinson's disease: motor signs, depression, anxiety, cognition, and other nonmotor symptoms. In the health status scores, 19.6% of variance was explained by age, number of comorbidities, disease duration, and levodopa equivalent dose. Younger age predicted worse health status. A full regression model containing baseline variables and all 5 symptom domains explained 56% of the variance in health status. The standardized beta coefficient for depression was 2.1, 1.6, and 1.3 times that of motor signs, anxiety, and other nonmotor symptoms, respectively. Our findings provide a ranking order of clinical variables for their relative impact on health status in Parkinson's disease and show that depression has more than twice the impact of motor signs on health status. Anxiety and other nonmotor symptoms are also important separate determinants of poor health status in Parkinson's disease. Our results will help to guide the development of individual care and service planning for patients with Parkinson's disease. © 2011 Movement Disorder Society
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Non-motor symptoms of Parkinson's disease can be as disabling as motor symptoms, if not more so.
“The non-motor symptoms of Parkinson’s disease (PD) can be as disabling for an individual as their motor symptoms, if not more so [1].”
From Distant delivery of a mindfulness-based intervention for people with Parkinson's disease: The study protocol of a randomised pilot trial (2017) · cites this paper as [1]
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Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Discovering Statistics Using SPSS
Field, A. P., & Miles, J. N. V. (2000) · Medical Entomology and Zoology · Cited by 28,268 · see citing works
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · cited 1× · see citing works
“Stage of disease was determined using the Hoehn and Yahr scale (H&Y).(14) Number of comorbid physical conditions was assessed using the Physical Health measure from the Duke Older Americans Resources and Services assessment.”
MethodMioshi, E., Dawson, K., Mitchell, J., Arnold, R., & Hodges, J. R. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1610 · Cited by 2,016 · see citing works
Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., et al. (2009) · Movement Disorders · doi:10.1002/mds.22643 · Cited by 1,445 · see citing works
What contributes to quality of life in patients with Parkinson's disease?
Schrag, A. E. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.3.308 · Cited by 1,380 · see citing works
Chaudhuri, К. R., Martínez‐Martín, P., Brown, R. G., Sethi, K. D., Stocchi, F., Odin, P., Ondo, W. G., Abe, K., Macphee, G. J. A., MacMahon, D., et al. (2007) · Movement Disorders · doi:10.1002/mds.21596 · Cited by 1,092 · see citing works
Self-citationFillenbaum, G. G. (1988) · Medical Entomology and Zoology · Cited by 774 · see citing works
Irreversible motor impairment in young addicts ? ephedrone, manganism or both?
Sikk, K., Taba, P., Haldre, S., Bergquist, J., Nyholm, D., Zjablov, G., Asser, T., & Aquilonius, S. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00818.x · Cited by 664 · see citing works
Puhan, M. A., Frey, M., Büchi, S., & Schünemann, H. J. (2008) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-6-46 · Cited by 586 · see citing works
The Clinically Important Difference on the Unified Parkinson's Disease Rating Scale
Shulman, L. M., Gruber‐Baldini, A. L., Anderson, K. E., Fishman, P. S., Reich, S. G., & Weiner, W. J. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.295 · Cited by 555 · see citing works
Quality of life in Parkinson's disease: the relative importance of the symptoms
Rahman, S., Griffin, H. J., Quinn, N. P., & Jahanshahi, M. (2008) · Movement Disorders · doi:10.1002/mds.21667 · Cited by 532 · see citing works
Impact of the motor complications of Parkinson's disease on the quality of life
Chapuis, S., Ouchchane, L., Metz, O., Gerbaud, L., & Durif, F. (2004) · Movement Disorders · doi:10.1002/mds.20279 · Cited by 522 · see citing works
Factors impacting on quality of life in Parkinson's disease: Results from an international survey
The Global Parkinson's Disease Survey (GPDS) Steering Committee (2002) · Movement Disorders · doi:10.1002/mds.10010 · Cited by 521 · see citing works
The PDQ-8: Development and validation of a short-form parkinson's disease questionnaire
Jenkinson, C., Fitzpatrick, R. M., Peto, V., Greenhall, R., & Hyman, N. M. (1997) · Psychology and Health · doi:10.1080/08870449708406741 · Cited by 462 · see citing works
Determinants of health-related quality of life in Parkinson’s disease: A systematic review
Soh, S., Morris, M. E., & McGinley, J. L. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.08.012 · Cited by 387 · see citing works
Determinants of disability and quality of life in mild to moderate Parkinson disease
Muslimović, D., Post, B., Speelman, J. D., Schmand, B. A., & de Haan, R. J. (2008) · Neurology · doi:10.1212/01.wnl.0000313835.33830.80 · Cited by 351 · see citing works
Karlsen, K. H., Larsen, J. O., Tandberg, E., & Maland, J. G. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.4.431 · Cited by 318 · see citing works
Minimal clinically important change on the unified Parkinson's disease rating scale
Schrag, A. E., Sampaio, C., Counsell, N., & Poewe, W. H. (2006) · Movement Disorders · doi:10.1002/mds.20914 · Cited by 298 · see citing works
Young‐ versus older‐onset Parkinson's disease: Impact of disease and psychosocial consequences
Schrag, A. E., Hovris, A., Morley, D., Quinn, N. P., & Jahanshahi, M. (2003) · Movement Disorders · doi:10.1002/mds.10527 · Cited by 287 · see citing works
Clinical significance of patient-reported questionnaire data: another step toward consensus
Sloan, J. A., Cella, D. F., & Hays, R. D. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.07.009 · Cited by 263 · see citing works
Depression and anxiety related subtypes in Parkinson's disease
Brown, R. G., Landau, S., Hindle, J. V., Playfer, J., Samuel, M., Wilson, K. C., Hurt, C. S., Anderson, R. J., Carnell, J., Dickinson, L., et al. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.213652 · Cited by 183 · see citing works
Self-citationQuality of life in patients with Parkinson's disease
Behari, M., Srivastava, A. K., & Pandey, R. M. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.12.005 · Cited by 179 · see citing works
Anxious and depressive symptoms in Parkinson's disease: The French cross‐sectionnal DoPaMiP study
Nègre‐Pagès, L., Grandjean, H., Lapeyre‐Mestre, M., Montastruc, J. L., Fourrier, A., Lepine, J. P., Rascol, O., & on behalf of the DoPaMiP Study Group (2009) · Movement Disorders · doi:10.1002/mds.22760 · Cited by 176 · see citing works
Self-citationQuality of life and related concepts in Parkinson's disease: A systematic review
Oudsten, B. L. D., Heck, G. L. V., & Vries, J. D. (2007) · Movement Disorders · doi:10.1002/mds.21567 · Cited by 166 · see citing works
Quantitation of non‐motor symptoms in Parkinson’s disease
Chaudhuri, К. R., & Martínez‐Martín, P. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02212.x · Cited by 160 · see citing works
Hobson, P. (1999) · Age and Ageing · doi:10.1093/ageing/28.4.341 · Cited by 152 · see citing works
Klepac, N., Trkulja, V., Relja, M., & Babić, T. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.02011.x · Cited by 146 · see citing works
Sławek, J. W., Derejko, M., & Lass, P. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2005.04.006 · Cited by 142 · see citing works
Jenkinson, C., & Fitzpatrick, R. M. (2006) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2006.06.006 · Cited by 123 · see citing works
Carod-Artal, F. J., Ziomkowski, S., Mesquita, H., & Martínez‐Martín, P. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.06.011 · Cited by 121 · see citing works
A comprehensive model of health-related quality of life in Parkinson’s disease
Jeukens‐Visser, M., van Rooden, S. M., Verbaan, D., Marinus, J., Stiggelbout, A. M., & van Hilten, J. J. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0994-4 · Cited by 117 · see citing works
Force overflow and levodopa‐induced dyskinesias in Parkinson’s disease
Wenzelburger, R., Zhang, B., Pohle, S., Klebe, S., Lorenz, D., Herzog, J., Wilms, H., Deuschl, G., & Krack, P. (2002) · Brain · doi:10.1093/brain/awf084 · Cited by 102 · see citing works
Qin, Z., Zhang, L., Sun, F., Fang, X., Meng, C., Tanner, C. M., & Chan, P. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.05.011 · Cited by 101 · see citing works
Psychometric attributes of the Hospital Anxiety and Depression Scale in Parkinson's disease
Rodriguez‐Blazquez, C., Frades‐Payo, B., Forjaz, M. J., de Pedro‐Cuesta, J., Martinez‐Martin, P., & on behalf of the Longitudinal Parkinson's Disease Patient Study (Estudio longitudinal de pacientes con enfermedad de Parkinson ‐ELEP) Group (2009) · Movement Disorders · doi:10.1002/mds.22321 · Cited by 97 · see citing works
Self-citationQuality of life measurements in patients with Parkinson's disease: A community‐based study
Karlsen, K., Larsen, J. O., Tandberg, E., & Jg, M. (1998) · European Journal of Neurology · doi:10.1046/j.1468-1331.1998.550443.x · Cited by 90 · see citing works
Addenbrooke’s Cognitive Examination validation in Parkinson’s disease
Reyes, M., Perez‐Lloret, S., Gerscovich, E. R., Martín, M., Leiguarda, R. C., & Merello, M. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02384.x · Cited by 88 · see citing works
A Longitudinal Evaluation of Health-Related Quality of Life of Patients with Parkinson's Disease
Jeukens‐Visser, M., Verbaan, D., van Rooden, S. M., Marinus, J., van Hilten, J. J., & Stiggelbout, A. M. (2008) · Value in Health · doi:10.1111/j.1524-4733.2008.00430.x · Cited by 68 · see citing works
Davidson, J. R. T., Allgulander, C., Pollack, M. H., Hartford, J. T., Erickson, J., Russell, J. M., David, P., Wohlreich, M. M., Carlson, J. L., & Raskin, J. (2008) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.949 · Cited by 57 · see citing works
Validation of PDQ-8 as an independent instrument in English and Chinese
Tan, L. C. S., Lau, P., Au, W., & Luo, N. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.072 · Cited by 51 · see citing works
Paraneoplastic choreic syndrome during non-Hodgkin's lymphoma
Nuti, A., Ceravolo, R., Salvetti, S., Gambaccini, G., Bonuccelli, U., & Capochiani, E. (2000) · Movement Disorders · doi:10.1002/1531-8257(200003)15:2 · Cited by 27 · see citing works
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [5]5. Kuopio AM, Marttila RJ, Helenius H, Toivonen M, Rinne UK. The quality of life in Parkinson's disease. Mov Disord 2000;15(2):216-223.
Cited by
Sorted by citations
Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415 · see citing works
Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.Preprint
Winner, B., & Winkler, J. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021287 · Cited by 303 · see citing works
Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial
Phillips, M. C. L., Murtagh, D. K. J., Gilbertson, L. J., Asztely, F. J. S., & Lynch, C. D. P. (2018) · Movement Disorders · doi:10.1002/mds.27390 · Cited by 292 · see citing works
Lindqvist, D., Hall, S., Surova, Y., Nielsen, H. M., Janelidze, S., Brundin, L., & Hansson, O. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.07.007 · Cited by 272 · see citing works
van Uem, J. M. T., Marinus, J., Canning, C. G., van Lummel, R. C., Dodel, R. C., Liepelt‐Scarfone, I., Berg, D., Morris, M. E., & Maetzler, W. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.014 · Cited by 207 · see citing works
Progression of motor symptoms in Parkinson’s disease
Xia, R., & Mao, Z. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1050-z · Cited by 186 · see citing works
Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease
Santos‐García, D., & de la Fuente‐Fernández, R. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.07.005 · Cited by 164 · see citing works
Santos‐García, D., Fonticoba, T. D. D., Castro, E. S., Borrué, C., Mata, M., Vila, B. S., Foraster, A. C., Saúco, M. Á., Pérez, A. B. R., Vela, L., et al. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.07.031 · Cited by 143 · see citing works
Frucht, S. J. (2004) · The Neurologist · doi:10.1097/01.nrl.0000131146.08278.a5 · Cited by 139 · see citing works
Dobkin, R. D., Mann, S. L., Gara, M. A., Interian, A., Rodriguez, K. M., & Menza, M. (2020) · Neurology · doi:10.1212/wnl.0000000000009292 · Cited by 127 · see citing works
Predictors of health-related quality of life in Parkinson's disease
Kuhlman, G. D., Flanigan, J. L., Sperling, S. A., & Barrett, M. J. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.05.009 · Cited by 125 · see citing works
Deuel, L. M., & Seeberger, L. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00900-y · Cited by 131 · see citing works
Nonmotor Symptoms in Parkinson’s Disease in 2012: Relevant Clinical Aspects
Bonnet, A. M., Jutras, M., Czernecki, V., Corvol, J., & Vidailhet, M. (2012) · Parkinson s Disease · doi:10.1155/2012/198316 · Cited by 119 · see citing works
Chaudhuri, К. R., Sauerbier, A., Rojo, J. M., Sethi, K. D., Schapira, A. H. V., Brown, R. G., Antonini, A., Stocchi, F., Odin, P., Bhattacharya, K., et al. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.12.031 · Cited by 113 · see citing works
Self-citationKohl, Z., Abdallah, N. B. B., Vogelgsang, J., Tischer, L., Deusser, J., Amato, D., Anderson, S., Müller, C., Riess, O., Masliah, E., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.021 · Cited by 89 · see citing works
Luquín, M. R., Kulisevsky, J., Martínez‐Martín, P., Mir, P., & TOLOSA, E. S. (2017) · Parkinson s Disease · doi:10.1155/2017/4047392 · Cited by 104 · see citing works
Berganzo, K., Tijero, B., González-Eizaguirre, A., Somme, J. H., Lezcano, E., Gabilondo, I., Fernandez, M., Zarranz, J. J., & Gómez‐Esteban, J. C. (2016) · Neurología (English Edition) · doi:10.1016/j.nrleng.2014.10.016 · Cited by 102 · see citing works
Port, R. J., Rumsby, M. G., Brown, G., Harrison, I. F., Amjad, A., & Bale, C. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202346 · Cited by 100 · see citing works
Berganzo, K., Tijero, B., González-Eizaguirre, A., Somme, J. H., Lezcano, E., Gabilondo, I., Fernández, M., Zarranz, J. J., & Gómez‐Esteban, J. C. (2014) · Neurología · doi:10.1016/j.nrl.2014.10.010 · Cited by 98 · see citing works
Quality of Life and Nonmotor Symptoms in Parkinson's Disease
Barone, P., Erro, R., & Picillo, M. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.023 · Cited by 98 · see citing works
Palliative care for Parkinson’s disease: A summary of the evidence and future directions
Richfield, E. W., Jones, E. J., & Alty, J. (2013) · Palliative Medicine · doi:10.1177/0269216313495287 · Cited by 82 · see citing works
Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease?
Barnum, C. J., & Tansey, M. G. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0283-6 · Cited by 80 · see citing works
Non-motor symptoms of Parkinson’s disease: the patient’s perspective
Breen, K. C., & Drutyte, G. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0928-2 · Cited by 74 · see citing works
Wu, Y., Guo, X., Wei, Q.-Q., Ou, R., Song, W., Cao, B., Zhao, B., & Shang, H. (2015) · Acta Neurologica Scandinavica · doi:10.1111/ane.12461 · Cited by 71 · see citing works
Defining Palliative Care Needs in Parkinson's Disease
Kluger, B. M., Shattuck, J., Berk, J., Sebring, K., Jones, W. E., Brunetti, F., Fairmont, I., Bowles, D. W., Sillau, S., & Bekelman, D. B. (2018) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12702 · Cited by 68 · see citing works
Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's
Hurt, C. S., Rixon, L., Chaudhuri, К. R., Moss-Morris, R. E., Samuel, M., & Brown, R. G. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.04.014 · Cited by 65 · see citing works
Self-citationCalió, M. L., Henriques, E., Siena, A., Bertoncini, C. R. A., Gil-Mohapel, J., & Rosenstock, T. R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00679 · Cited by 64 · see citing works
Efficient detection of Parkinson's disease using deep learning techniques over medical data
Sahu, L., Sharma, R., Sahu, I., Das, M., Sahu, B., & Kumar, R. (2021) · Expert Systems · doi:10.1111/exsy.12787 · Cited by 64 · see citing works
Martínez‐Martín, P., Rodríguez‐Blázquez, C., Forjaz, M. J., Álvarez, M., Arakaki, T., Bergareche‐Yarza, A., Chade, A. R., Garretto, N., Gershanik, O. S., Kurtis, M. M., et al. (2014) · European Journal of Neurology · doi:10.1111/ene.12349 · Cited by 62 · see citing works
Natural Phenolic Compounds with Neuroprotective Effects
Tavan, M., Hanachi, P., Cádiz‐Gurrea, M. D. L. L., Segura‐Carretero, A., & Mirjalili, M. H. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04046-z · Cited by 62 · see citing works
Fox, S., Cashell, A., Kernohan, G. W., Lynch, M., McGlade, C., O’Brien, T., O’Sullivan, S. S., Foley, M. J., & Timmons, S. (2016) · Palliative Medicine · doi:10.1177/0269216316669922 · Cited by 54 · see citing works
Bentea, E., der Perren, A. V., Liefferinge, J. V., Arfani, A. E., Albertini, G., Demuyser, T., Merckx, E., Michotte, Y. M., Smolders, I. J., Baekelandt, V., et al. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00068 · Cited by 53 · see citing works
Klingelhoefer, L., Rizos, A., Sauerbier, A., McGregor, S., Martínez‐Martín, P., Reichmann, H., Horne, M. K., & Chaudhuri, К. R. (2016) · European Journal of Neurology · doi:10.1111/ene.13015 · Cited by 53 · see citing works
Does nutritional status affect Parkinson's Disease features and quality of life?
Ongun, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205100 · Cited by 52 · see citing works
Peña‐Díaz, S., García‐Pardo, J., & Ventura, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030839 · Cited by 53 · see citing works
Gender differences in quality of life following subthalamic stimulation for Parkinson's disease
Hariz, G., Limousin, P. D., Zrinzo, L. U., Tripoliti, E., Avilés-Olmos, I., Jahanshahi, M., Hamberg, K., & Foltynie, T. (2013) · Acta Neurologica Scandinavica · doi:10.1111/ane.12127 · Cited by 52 · see citing works
Simpson, J., Lekwuwa, G., & Crawford, T. J. (2014) · Disability and Rehabilitation · doi:10.3109/09638288.2014.883442 · Cited by 52 · see citing works
Cognition, coping, and outcome in Parkinson's disease
Hurt, C. S., Landau, S., Burn, D. J., Hindle, J. V., Samuel, M., Wilson, K., & Brown, R. G. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212000749 · Cited by 52 · see citing works
Self-citationReddy, P., Martínez‐Martín, P., Brown, R. G., Chaudhuri, К. R., Lin, J., Selway, R., Forgács, I., Ashkan, K., & Samuel, M. (2014) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-12-11 · Cited by 50 · see citing works
Self-citationQuality of life in Parkinson's disease: A gender‐specific perspective
Balash, Y., Korczyn, A. D., Migirov, A. A., & Gurevich, T. (2019) · Acta Neurologica Scandinavica · doi:10.1111/ane.13095 · Cited by 50 · see citing works
Predictors of clinically significant quality of life impairment in Parkinson’s disease
Santos‐García, D., Fonticoba, T. D. D., Bartolomé, C. C., Muñoz, G., González, J. M. P., Miró, C. M., Suárez, E., Jesús, S., Aguilar, M., Pástor, P., et al. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00256-w · Cited by 47 · see citing works
Wu, Y., Guo, X. Y., Wei, Q. Q., Song, W., Chen, K., Cao, B., Ou, R., Zhao, B., & Shang, H. F. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.03.014 · Cited by 47 · see citing works
Patients' Expectations in Subthalamic Nucleus Deep Brain Stimulation Surgery for Parkinson Disease
Hasegawa, H., Samuel, M., Douiri, A., & Ashkan, K. (2014) · World Neurosurgery · doi:10.1016/j.wneu.2014.02.001 · Cited by 43 · see citing works
Self-citationJones, J. D., Hass, C. J., Mangal, P. C., Lafo, J., Okun, M. S., & Bowers, D. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.09.014 · Cited by 45 · see citing works
Santos‐García, D., Jesús, S., Aguilar, M., Planellás, L., Caldentey, J. G., Caballol, N. S., Legarda, I., Hernández‐Vara, J., Cabo, I., Manzanares, L. L., et al. (2019) · European Journal of Neurology · doi:10.1111/ene.14008 · Cited by 45 · see citing works
Self-citationStefani, A., Peppe, A., Galati, S., Bassi, M. S., D’Angelo, V., & Pierantozzi, M. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00068 · Cited by 44 · see citing works
von Eichel, H., Heine, J., Wegner, F., Rogozinski, S., Stiel, S., Groh, A., Krey, L., Höglinger, G. U., & Klietz, M. (2022) · Brain Sciences · doi:10.3390/brainsci12010089 · Cited by 44 · see citing works
Grau‐Sánchez, J., Jamey, K., Paraskevopoulos, E., Bella, S. D., Gold, C., Gottfried Schlaug, A., Belleville, S., Rodríguez‐Fornells, A., Hackney, M. E., & Särkämö, T. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14892 · Cited by 41 · see citing works
Rodríguez‐Violante, M., Ospina-García, N., Dávila-Avila, N. M., Cruz-Fino, D., de la Cruz-Landero, A., & Cervantes‐Arriaga, A. (2018) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20180074 · Cited by 40 · see citing works
Cognitive and Neuropsychiatric Features in Parkinson's and Lewy Body Dementias
Fields, J. A. (2017) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acx085 · Cited by 40 · see citing works
Morberg, B. M., Jensen, J., Bode, M., & Wermuth, L. (2014) · Neurorehabilitation · doi:10.3233/nre-141119 · Cited by 38 · see citing works
He, L., Lee, E.-Y., Sterling, N. W., Kong, L., Lewis, M. M., Du, G., Eslinger, P. J., & Huang, X. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-160851 · Cited by 37 · see citing works
Depressive symptoms in Parkinson’s disease correlate with cortical atrophy over time
Hanganu, A., Bruneau, M., Degroot, C., Bedetti, C., Mejia‐Constain, B., Lafontaine, A., Chouinard, S., & Monchi, O. (2016) · Brain and Cognition · doi:10.1016/j.bandc.2016.11.001 · Cited by 37 · see citing works
Martínez‐Martín, P., Kulisevsky, J., Mir, P., TOLOSA, E. S., García-Delgado, P., & Luquín, M. R. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0056-2 · Cited by 36 · see citing works
Emerging drugs for autonomic dysfunction in Parkinson's disease
Perez‐Lloret, S., Rey, M. V., Traon, A. P., & Rascol, O. (2013) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2013.766168 · Cited by 35 · see citing works
Factors Associated with Health‐Related Quality of Life in Late‐Stage Parkinson's Disease
Rosqvist, K., Odin, P., Lorenzl, S., Meissner, W. G., Bloem, B. R., Ferreira, J. J., Dodel, R. C., & Schrag, A. E. (2021) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13186 · Cited by 33 · see citing works
Heterogeneous Determinants of Quality of Life in Different Phenotypes of Parkinson’s Disease
Fereshtehnejad, S., Shafieesabet, M., Farhadi, F., Hadizadeh, H., Rahmani, A., Naderi, N., Khaefpanah, D., Shahidi, G. A., Delbari, A., & Lökk, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137081 · Cited by 32 · see citing works
Mental health in Parkinson’s disease after receiving aquatic therapy: a clinical trial
la Cruz, S. P. (2018) · Acta Neurologica Belgica · doi:10.1007/s13760-018-1034-5 · Cited by 32 · see citing works
Subthalamic deep brain stimulation improves sleep and excessive sweating in Parkinson’s disease
Bjerknes, S., Skogseid, I. M., Hauge, T. J., Dietrichs, E., & Toft, M. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-020-00131-0 · Cited by 33 · see citing works
Santos‐García, D., Castro, E. S., Ernandez, J. J., Ruiz, I. E., Gesto, C. T., Aneiros-Díaz, M., de Deus-Fonticoba, T., López-Fernández, M. F., & Núñez-Arias, D. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988717743589 · Cited by 31 · see citing works
Clinical Determinants of Health-related Quality of Life in Mexican Patients with Parkinson’s Disease
Rodríguez‐Violante, M., Cervantes‐Arriaga, A., Corona, T., Martínez-Ramírez, D., Morales‐Briceño, H., & Martínez‐Martín, P. (2013) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.01.005 · Cited by 31 · see citing works
Lelos, M. J., Morgan, R. J., Kelly, C., Torres, E. M., Rosser, A., & Dunnett, S. B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.003 · Cited by 31 · see citing works
An Update of the Impact of Deep Brain Stimulation on Non Motor Symptoms in Parkinson's Disease
Klingelhoefer, L., Samuel, M., Chaudhuri, К. R., & Ashkan, K. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130273 · Cited by 30 · see citing works
Self-citationBashir, S., Aiman, A., Shahid, M., Chaudhary, A. A., Sami, N., Basir, S. F., Hassan, M. I., & Islam, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102276 · Cited by 31 · see citing works
Gülünay, A., Çakmaklı, G. Y., Yön, M. İ., Ulusoy, E. K., & Karakoc, M. (2019) · Psychogeriatrics · doi:10.1111/psyg.12489 · Cited by 29 · see citing works
What influences placebo and nocebo responses in Parkinson's disease?
Witek, N. P., Stebbins, G. T., & Goetz, C. G. (2018) · Movement Disorders · doi:10.1002/mds.27416 · Cited by 27 · see citing works
Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease
Fan, Y., Liang, X., Han, L., Shen, Y., Shen, B., Chen, C., Sun, Y., Wang, J., & Tang, Y. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00269 · Cited by 25 · see citing works
Strategies to Maintain Quality of Life Among People With Parkinson’s Disease: What works?
Fereshtehnejad, S. (2016) · Neurodegenerative Disease Management · doi:10.2217/nmt-2016-0020 · Cited by 25 · see citing works
Dewsbury, L. S., Lim, C. K., & Steiner, G. Z. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa180 · Cited by 24 · see citing works
TOLOSA, E. S., Ebersbach, G., Ferreira, J. J., Rascol, O., Antonini, A., Foltynie, T., Gibson, R., Magalhães, D., Rocha, J., & Lees, A. J. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212611 · Cited by 23 · see citing works
Valkovič, P., Haršány, J., Hanáková, M., Martinkova, J., & Benetin, J. (2014) · ISRN Neurology · doi:10.1155/2014/587302 · Cited by 23 · see citing works
The impact of deep brain stimulation on the nonmotor symptoms of Parkinson’s disease
Ashkan, K., Samuel, M., Reddy, P., & Chaudhuri, К. R. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0912-x · Cited by 22 · see citing works
Self-citationIdentifying barriers to help-seeking for non-motor symptoms in people with Parkinson’s disease
Hurt, C. S., Rixon, L., Chaudhuri, К. R., Moss-Morris, R. E., Samuel, M., & Brown, R. G. (2016) · Journal of Health Psychology · doi:10.1177/1359105316683239 · Cited by 22 · see citing works
Self-citationLee, S.-Y., Kim, S. K., Cheon, S., Seo, J.-W., Kim, M. A., & Kim, J. W. (2016) · BMC Neurology · doi:10.1186/s12883-016-0600-9 · Cited by 21 · see citing works
Thinking about motor fluctuations: An examination of metacognitions in Parkinson's disease
Fernie, B. A., Spada, M. M., Chaudhuri, К. R., Klingelhoefer, L., & Brown, R. G. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.05.001 · Cited by 20 · see citing works
Self-citationHurt, C. S., Alkufri, F., Brown, R. G., Burn, D. J., Hindle, J. V., Landau, S., Wilson, K., Samuel, M., & on behalf of the PROMS-PD study group (see acknowledgements) (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130314 · Cited by 19 · see citing works
Self-citationHermanowicz, N. S., Castillo-Shell, M., McMean, A., Fishman, J., & D’Souza, J. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s196930 · Cited by 18 · see citing works
Mobility, mood and site of care impact health related quality of life in Parkinson's disease
Nutt, J. G., Siderowf, A. D., Guttman, M., Schmidt, P. N., Zamudio, J., Wu, S. S., Okun, M. S., Simuni, T., Parashos, S. A., Dahodwala, N. A., et al. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.10.004 · Cited by 17 · see citing works
Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project
Santos‐García, D., Estrada, M. B., Calopa, M., Sevilla, F. E., Freire, E., Ruiz, P., Grandas, F., Kulisevsky, J., Manzanares, L. L., Martínez‐Castrillo, J. C., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11081027 · Cited by 16 · see citing works
Depression and associated factors in nondemented Chinese patients with Parkinson’s disease
Zhu, J., Lu, L., Pan, Y., Shen, B., Xu, S., Hou, Y., Zhang, X., & Zhang, L. (2017) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2017.10.031 · Cited by 16 · see citing works
Guo, X., Chen, F., Pu, J., Jiang, H., Zhu, Z., Zheng, Z., Zhang, J., Chen, G., Zhu, J., & Wu, H. (2022) · Neurosurgery · doi:10.1227/neu.0000000000002274 · Cited by 14 · see citing works
State-of-the-art pharmacotherapy for autonomic dysfunction in Parkinson’s disease
Quarracino, C., Losada, M. E. O., Capani, F., & Perez‐Lloret, S. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1713097 · Cited by 14 · see citing works
Bogosian, A., Hurt, C. S., Vasconcelos e Sa, D., Hindle, J. V., McCracken, L., & Cubi-Molla, P. (2017) · Pilot and Feasibility Studies · doi:10.1186/s40814-016-0117-4 · Cited by 12 · see citing works
Self-citationBogosian, A., Rixon, L., & Hurt, C. S. (2020) · Research Involvement and Engagement · doi:10.1186/s40900-020-00212-7 · Cited by 12 · see citing works
Self-citationCare of Late‐Stage Parkinsonism: Resource Utilization of the Disease in Five European Countries
Kruse, C., Lipinski, A. L., Verheyen, M., Balzer‐Geldsetzer, M., Wittenberg, M., Lorenzl, S., Richinger, C., Schmotz, C., Tönges, L., Woitalla, D., et al. (2024) · Movement Disorders · doi:10.1002/mds.29718 · Cited by 12 · see citing works
Palliative Care Need and Quality of Life Mediated by Psychological Distress in Neurologic Diseases
Chan, L. M. L., Choi, E. P. H., Lam, W., Chan, K. H., Pang, S., & Kwok, J. Y. Y. (2025) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2025.03.004 · Cited by 11 · see citing works
An insight into Parkinson’s disease: researches and its complexities
Saikia, A., Hussain, M., Barua, A. R., & Paul, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817913-0.00009-2 · Cited by 11 · see citing works
Spadaro, L., Bonanno, L., Lorenzo, G. D., Bramanti, P., & Marino, S. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.17.010 · Cited by 10 · see citing works
Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease
Karlstedt, M., Fereshtehnejad, S., Aarsland, D., & Lökk, J. (2018) · Parkinson s Disease · doi:10.1155/2018/9548681 · Cited by 9 · see citing works
Influence of Depressive Symptoms on Dopaminergic Treatment of Parkinson’s Disease
Hanganu, A., Degroot, C., Monchi, O., Bedetti, C., Mejia‐Constain, B., Lafontaine, A., Chouinard, S., & Bruneau, M. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00188 · Cited by 9 · see citing works
Culicetto, L., Formica, C., Buono, V. L., Latella, D., Maresca, G., Brigandì, A., Sorbera, C., Lorenzo, G. D., Quartarone, A., & Marino, S. (2024) · Parkinson s Disease · doi:10.1155/2024/5551796 · Cited by 8 · see citing works
Pilipovich, A. A., Ov, V., Makarov, S. A., Shindryaeva, N. N., & Vorob’eva, Y. D. (2022) · Parkinson s Disease · doi:10.1155/2022/1571801 · Cited by 8 · see citing works
Choi, S.-M., Cho, S., Choe, Y., & Kim, B. C. (2023) · Medicine · doi:10.1097/md.0000000000032674 · Cited by 7 · see citing works
Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes
Fan, Y., Zhang, M., Liang, X., Shen, B., Xu, Z., Li, S., Hu, T., Wu, B., Zhao, J., Sun, Y., et al. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51475 · Cited by 8 · see citing works
State-dependent alteration of respiration in a rat model of Parkinson's disease
Walker, J., Meunier, E., Garcia, S., Messaoudi, B., Mouly, A., Veyrac, A., Buonviso, N., & Courtiol, E. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114740 · Cited by 7 · see citing works
Isolation of Adult Mouse Neural Stem Cells and Assessment of Self-Renewal by ELDA
Rasool, D., Soleimani, V. D., & Jahani‐Asl, A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2409-8_21 · Cited by 6 · see citing works
Parkinson’s disease – palliative care needs assessment tool: adaptation and psychometric testing
Richfield, E. W., Allgar, V. L., Girgis, A., & Johnson, M. J. (2022) · BMJ Supportive & Palliative Care · doi:10.1136/spcare-2021-003447 · Cited by 6 · see citing works
Quality of life: Seasonal fluctuation in Parkinson's disease
Wu, L., Li, S., Tang, Y., Liang, X., Xu, Z., Hu, T., Liu, X., Cai, M., & Liu, X. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2022.1035721 · Cited by 5 · see citing works
Maggio, M. G., Culicetto, L., Bonanno, L., Luca, R. D., Corallo, F., Rizzo, A., Marino, S., Quartarone, A., Luca, A., Nicoletti, A. S. Q., et al. (2025) · Journal of Health Psychology · doi:10.1177/13591053241312505 · Cited by 5 · see citing works
Cova, I., Battista, M. E. D., Vanacore, N., Papi, C. P., Alampi, G., Rubino, A., Valente, M., Meco, G., Contri, P., Pucchio, A. D., et al. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2830-z · Cited by 5 · see citing works
- Authors
- Hinnell, C., Hurt, C. S., Landau, S., Brown, R. G., Samuel, M., & on behalf of the PROMS‐PD Study Group
- Affiliations
- Kings Health Partners (GB)
- King's College London (GB)
- William Harvey Hospital (GB)
- Corresponding author
- Samuel, Michael
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2011-09-27
- Volume
- 27
- Issue
- 2
- Pages
- 236-241
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2029474945
- Cited by
- 142
- References
- 42
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 13 · 2021: 8 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 7
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- City Research Online (City University London) (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Parkinson's UK (J-0601)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, health status, non-motor symptoms, motor symptoms, depression, anxiety, cognition, Parkinson's Disease Questionnaire, levodopa equivalent daily dose, comorbidities, disease duration
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Anxiety, Depression, Disability Evaluation, Female, Health Status, Humans, Male, Middle Aged, Parkinson Disease, Quality of Life, Surveys and Questionnaires, Regression Analysis, Severity of Illness Index, Cohort Studies
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