Measuring the impact of Parkinson's disease with the Parkinson's Disease Quality of Life questionnaire
Abstract
OBJECTIVES: To assess the validity of the Parkinson's Disease Quality of Life (PDQL) questionnaire, a patient-specific multi-dimensional quality of life measure, in a community-based sample of patients with Parkinson's disease (PI)) using standardized measures of disease severity, depressive symptomatology and cognitive function. DESIGN: A group of 194 patients with probable PD were randomly selected from a community-based register and were invited to self-complete the 37-item PDQL. Disease severity was measured by the disease-specific Webster scale, cognition by the CAMCOG neuropsychological test and depressive symptomatology by the self-report 15-item GDS-15 geriatric depression scale. RESULTS: A total of 136 patients returned completed PDQL questionnaires. Significant differences (P < 0.05) emerged between the pooled PDQL score of patients grouped on the basis of disease severity. Depressive symptoms and cognition were also associated with poorer perceived quality of life as measured by the PDQL. CONCLUSIONS: The results of this study are indicative of the validity of the PDQL as an important additional measurement which reflects the impact of PD from the patient perspective. It shows poorer quality of life to be associated with increasing age, disease severity more severe depressive symptomatology and impaired cognitive functioning. However, the responsiveness of this instrument in the evaluation of care in PD remains to be determined.
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Certain measures relating to neurological conditions specifically were coded under the 'nervous system' domain (e.g. Parkinson's Disease Questionnaire-39 and Functional Assessment of Cancer Therapy scale - Brain).
“Therefore, certain measures relating to neurological conditions specifically were coded under the ‘nervous system’ domain (e.g. Parkinson's Disease Questionnaire-39 106 and Functional Assessment of Cancer Therapy scale – Brain. 103 ).”
From A scoping review to identify process and outcome measures used in acceptance and commitment therapy research, with adults with acquired neurological conditions. (2023) · cites this paper as [106]
The Parkinson's Disease Questionnaire-39 is a valid and reliable instrument for patients with Parkinson's disease.
“The PDQ-39 is a valid and reliable instrument for patients with PD [42, 43].”
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“Therefore, certain measures relating to neurological conditions speci fi cally were coded under the ‘ nervous system ’ domain (e.g. Parkinson ’ s Disease Questionnaire-39 106 and Functional Assessment of Cancer Therapy scale – Brain.”
Background
- Authors
- Hobson, P.
- Affiliations
- Glan Clwyd Hospital (GB)
- Corresponding author
- Hobson, P
- ORCID
- Hobson, P
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07-01
- Volume
- 28
- Issue
- 4
- Pages
- 341-346
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2152512767
- Cited by
- 152
- References
- 18
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 7 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 4
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Age and Ageing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, quality of life, questionnaire validity, disease severity, depressive symptoms, cognitive function, community-based patients, patient-reported outcomes
- MeSH terms
- Aged, Aged, 80 and over, Analysis of Variance, Cognition Disorders, Depression, Female, Humans, Male, Middle Aged, Parkinson Disease, Quality of Life, Regression Analysis, Sampling Studies, Reproducibility of Results, Sickness Impact Profile
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