Cognitive profile of patients with newly diagnosed Parkinson disease
Abstract
OBJECTIVE: To determine the frequency and pattern of cognitive dysfunction in patients with newly diagnosed Parkinson disease (PD) and to identify its demographic and clinical correlates. METHODS: A cohort of 115 consecutive patients with newly diagnosed PD and 70 healthy controls underwent a comprehensive neuropsychological assessment including tests of psychomotor speed, attention, language, memory, executive and visuospatial functions, as well as measures of affective status. Patients also received quantitative ratings of motor symptom severity and functional status. Neuropsychological performance of PD patients was compared with that of healthy controls and with available normative data. Independent demographic and clinical predictors of cognitive impairment were identified with multiple logistic regression analysis. RESULTS: Relative to controls, PD patients performed significantly worse on most cognitive measures. However, further analysis revealed that group differences in cognitive performance could mainly be explained by measures of immediate memory and executive function. Comparison with normative data showed that impairments were most frequent on measures of executive function, memory and psychomotor speed. In all, 24% of PD patients (4% of controls) displayed defective performance on at least three neuropsychological tests and were classified as cognitively impaired. Late onset of disease was an independent predictor of cognitive dysfunction in PD. CONCLUSION: Cognitive impairments are common even in newly diagnosed Parkinson disease patients, with deficits being most prominent in the domains of memory and executive functions. Older age at disease onset is likely to be an important determinant of cognitive dysfunction in Parkinson disease.
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Mild cognitive impairment is already present in about a quarter of patients with early Parkinson disease.
“Mild cognitive impairment (MCI) is already present in about a quarter of patients with early PD.[12][13][14]”
From Does vigorous exercise have a neuroprotective effect in Parkinson disease? (2011) · cites this paper as [14]
Functional magnetic resonance imaging data suggests aerobic exercise may generate more efficient neuronal activity in prefrontal regions similarly affected in Parkinson's disease.
“In these studies, fMRI data suggests that aerobic exercise may generate more efficient neuronal activity in the prefrontal regions similarly affected in PD 65, 66.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [65]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622 · see citing works
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · see citing works
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822 · see citing works
A Modified Card Sorting Test Sensitive to Frontal Lobe Defects
Nelson, H. E. (1976) · Cortex · doi:10.1016/s0010-9452(76)80035-4 · Cited by 2,454 · see citing works
Wechsler Adult Intelligence Scale--Third Edition
Wechsler, D. (2019) · PsycTESTS Dataset · doi:10.1037/t49755-000 · Cited by 2,327 · see citing works
Massive IQ gains in 14 nations: What IQ tests really measure.
Flynn, J. R. (1987) · Psychological Bulletin · doi:10.1037/0033-2909.101.2.171 · Cited by 1,918 · see citing works
FRONTO-STRIATAL COGNITIVE DEFICITS AT DIFFERENT STAGES OF PARKINSON'S DISEASE
Owen, A. M., James-Galton, M., Leigh, P. N., Summers, B. A., MARSDEN, C. D., Quinn, N. P., Lange, K. W., & Robbins, T. W. (1992) · Brain · doi:10.1093/brain/115.6.1727 · Cited by 859 · see citing works
CLOX: an executive clock drawing task
Royall, D. R., Cordes, J. A., & Polk, M. J. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.5.588 · Cited by 839 · see citing works
COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSON'S DISEASE
Lees, A. J., & Smith, E. M. (1983) · Brain · doi:10.1093/brain/106.2.257 · Cited by 801 · see citing works
The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN study
Foltynie, T., Brayne, C., Robbins, T. W., & Barker, R. A. (2004) · Brain · doi:10.1093/brain/awh067 · Cited by 675 · see citing works
Cooper, J. A., SAGAR, H. J., Jordan, N., Harvey, N. S., & Sullivan, E. V. (1991) · Brain · doi:10.1093/brain/114.5.2095 · Cited by 626 · see citing works
Downes, J. J., Roberts, A. C., Sahakian, B. J., Evenden, J. L., Morris, R. G., & Robbins, T. W. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90128-0 · Cited by 527 · see citing works
Visual association test to detect early dementia of the Alzheimer type
Lindeboom, J. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.2.126 · Cited by 359 · see citing works
Cognitive impairments associated with early Parkinson's disease
Levin, B. E., Llabre, M. M., & Weiner, W. J. (1989) · Neurology · doi:10.1212/wnl.39.4.557 · Cited by 278 · see citing works
Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD
Esselink, R. A. J., de Bie, R. M. A., de Haan, R. J., Lenders, M. W. P. M., Nijssen, P. C. G., Staal, M. J., Smeding, H. M. M., Schuurman, P. R., Bosch, D. A., & Speelman, J. D. (2004) · Neurology · doi:10.1212/01.wnl.0000103235.12621.c3 · Cited by 254 · see citing works
Self-citationLevy, G., Tang, M. X., Cote, L. J., Louis, E. D., Alfaro, B., Mejía, H., Stern, Y., & Marder, K. S. (2000) · Neurology · doi:10.1212/wnl.55.4.539 · Cited by 225 · see citing works
DEPRESSION AND COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE
STARKSTEIN, S. E., Preziosi, T. J., Berthier, M. L., BOLDUC, P. L., Mayberg, H. S., & Robinson, R. G. (1989) · Brain · doi:10.1093/brain/112.5.1141 · Cited by 150 · see citing works
Normative Data for the Boston Naming Test in Native Dutch-Speaking Belgian Elderly
Mariën, P., Mampaey, E., Vervaet, A. M., Saerens, J., & Deyn, P. P. D. (1998) · Brain and Language · doi:10.1006/brln.1998.2000 · Cited by 147 · see citing works
Dujardin, K., Degreef, J., Rogelet, P., Defebvre, L., & Destée, A. (1999) · Journal of Neurology · doi:10.1007/s004150050455 · Cited by 115 · see citing works
Relation Between Clinical Characteristics of Parkinson's Disease and Cognitive Decline
Locascio, J. J., Corkin, S., & Growdon, J. H. (2003) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.25.1.94.13624 · Cited by 92 · see citing works
Depressed mood and executive dysfunction in early Parkinson's disease
Uekermann, J., Daum, I., Peters, S., Wiebel, B., Przuntek, H., & Müller, T. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.02155.x · Cited by 90 · see citing works
Lineweaver, T. T., Bondi, M. W., Thomas, R. G., & Salmon, D. P. (1999) · The Clinical Neuropsychologist · doi:10.1076/clin.13.3.328.1745 · Cited by 87 · see citing works
Age of disease onset influences cognition in Parkinson's disease
Katzen, H., Levin, B. E., & Llabre, M. L. (1998) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617798002859 · Cited by 38 · see citing works
(1965) · PubMed
Flagged first, then by citations
1 of the 29 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Overdependence on degraded gist memory in Alzheimer's disease.
Gallo, D. A., Shahid, K. R., Olson, M. A., Solomon, T. M., Schacter, D. L., & Budson, A. E. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.625 · Cited by 4,756 · see citing works
Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease
Hoops, S., Nazem, S., Siderowf, A. D., Duda, J. E., Xie, S. X., Stern, M. B., & Weintraub, D. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c34b47 · Cited by 1,258 · see citing works
Braun, M., Tupper, D. E., Kaufmann, P., McCrea, M., Postal, K., Westerveld, M., Wills, K., & Deer, T. M. (2011) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e3182351289 · Cited by 1,062 · see citing works
Iranzo, Á., Molinuevo, J. L., Santamaría, J., Serradell, M., Martı́, M. J., Valldeoriola, F., & Tolosa, E. S. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70476-8 · Cited by 950 · see citing works
Evolution of cognitive dysfunction in an incident Parkinson's disease cohort
Williams‐Gray, C. H., Foltynie, T., Brayne, C., Robbins, T. W., & Barker, R. (2007) · Brain · doi:10.1093/brain/awm111 · Cited by 935 · see citing works
The scientific and clinical basis for the treatment of Parkinson disease (2009)
Olanow, C. W., Stern, M. B., & Sethi, K. D. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a1d44c · Cited by 918 · see citing works
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Irwin, D. J., Lee, V. M. ‐., & Trojanowski, J. Q. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3549 · Cited by 875 · see citing works
Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
Rodríguez‐Oroz, M., Jahanshahi, M., Krack, P., Litvan, I., Macías, R. J., Bézard, E., & Obeso, J. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70293-5 · Cited by 866 · see citing works
MDS task force on mild cognitive impairment in Parkinson's disease: Critical review of PD‐MCI
Litvan, I., Aarsland, D., Adler, C. H., Goldman, J. G., Kulisevsky, J., Mollenhauer, B., Rodríguez‐Oroz, M., Tröster, A. I., & Weintraub, D. A. (2011) · Movement Disorders · doi:10.1002/mds.23823 · Cited by 811 · see citing works
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
Cognitive impairment in incident, untreated Parkinson disease: The Norwegian ParkWest Study
Aarsland, D., Brønnick, K., Larsen, J. P., Tysnes, O. B., & Alves, G. (2009) · Neurology · doi:10.1212/01.wnl.0000338632.00552.cb · Cited by 625 · see citing works
The epidemiology of dementia associated with Parkinson disease
Aarsland, D., & Kurz, M. W. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.08.034 · Cited by 572 · see citing works
Cognitive contributions to gait and falls: evidence and implications
Amboni, M., Barone, P., & Hausdorff, J. M. (2013) · Movement Disorders · doi:10.1002/mds.25674 · Cited by 565 · see citing works
Recurrent Falls in Parkinson’s Disease: A Systematic Review
Allen, N. E., Schwarzel, A. K., & Canning, C. G. (2013) · Parkinson s Disease · doi:10.1155/2013/906274 · Cited by 540 · see citing works
Does vigorous exercise have a neuroprotective effect in Parkinson disease?
Ahlskog, J. E. (2011) · Neurology · doi:10.1212/wnl.0b013e318225ab66 · Cited by 463 · see citing works
Executive dysfunction in <scp>P</scp> arkinson's disease: A review
Dirnberger, G., & Jahanshahi, M. (2013) · Journal of Neuropsychology · doi:10.1111/jnp.12028 · Cited by 486 · see citing works
Parkinson’s disease dementia: a neural networks perspective
Gratwicke, J., Jahanshahi, M., & Foltynie, T. (2015) · Brain · doi:10.1093/brain/awv104 · Cited by 436 · see citing works
The spectrum of nonmotor symptoms in early Parkinson disease
Khoo, T. K., Yarnall, A. J., Duncan, G. W., Coleman, S. Y., O'Brien, J. T., Brooks, D. J., Barker, R. A., & Burn, D. J. (2013) · Neurology · doi:10.1212/wnl.0b013e31827deb74 · Cited by 430 · see citing works
Mirelman, A., Maidan, I., Herman, T., Deutsch, J. E., Giladi, N., & Hausdorff, J. M. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq201 · Cited by 418 · see citing works
Kelly, V. E., Eusterbrock, A. J., & Shumway‐Cook, A. (2011) · Parkinson s Disease · doi:10.1155/2012/918719 · Cited by 403 · see citing works
Gill, D. J., Freshman, A., Blender, J. A., & Ravina, B. M. (2008) · Movement Disorders · doi:10.1002/mds.22017 · Cited by 388 · see citing works
Executive functions in Parkinson's disease: Systematic review and meta‐analysis
Kudlicka, A., Clare, L., & Hindle, J. V. (2011) · Movement Disorders · doi:10.1002/mds.23868 · Cited by 388 · see citing works
Athauda, D., & Foltynie, T. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.013 · Cited by 383 · see citing works
Metabolic brain networks associated with cognitive function in Parkinson's disease
Huang, C. C., Mattis, P. J., Tang, C., Perrine, K. R., Carbon, M., & Eidelberg, D. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.003 · Cited by 357 · see citing works
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
Klein, J. C., Eggers, C., Kalbe, E., Weisenbach, S., Hohmann, C., Vollmar, S., Baudrexel, S., Diederich, N. J., Heiß, W.-D., & Hilker, R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d55f61 · Cited by 355 · see citing works
Determinants of disability and quality of life in mild to moderate Parkinson disease
Muslimović, D., Post, B., Speelman, J. D., Schmand, B. A., & de Haan, R. J. (2008) · Neurology · doi:10.1212/01.wnl.0000313835.33830.80 · Cited by 351 · see citing works
Self-citationStocco, A., Lebiere, C. J., & Anderson, J. R. (2010) · Psychological Review · doi:10.1037/a0019077 · Cited by 352 · see citing works
Parkinson's disease‐cognitive rating scale: A new cognitive scale specific for Parkinson's disease
Pagonabarraga, J., Kulisevsky, J., Llebaria, G., García‐Sánchez, C., Pascual‐Sedano, B., & Gironell, A. (2008) · Movement Disorders · doi:10.1002/mds.22007 · Cited by 348 · see citing works
Premotor and nonmotor features of Parkinson's disease
Goldman, J. G., & Postuma, R. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000112 · Cited by 342 · see citing works
The Epidemiology of Dementia Associated with Parkinson's Disease
Aarsland, D., & Kurz, M. W. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00369.x · Cited by 340 · see citing works
Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis
Baiano, C., Barone, P., Trojano, L., & Santangelo, G. (2019) · Movement Disorders · doi:10.1002/mds.27902 · Cited by 338 · see citing works
Cognitive impairment and resting-state network connectivity in Parkinson's disease
Baggio, H. C., Segura, B., Sala‐Llonch, R., Martı́, M. J., Valldeoriola, F., Compta, Y., TOLOSA, E. S., & Junqué, C. (2014) · Human Brain Mapping · doi:10.1002/hbm.22622 · Cited by 316 · see citing works
Progression of Parkinson's disease in the clinical phase: potential markers
Maetzler, W., Liepelt, I., & Berg, D. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70291-1 · Cited by 307 · see citing works
Nazem, S., Siderowf, A. D., Duda, J. E., Have, T. T., Colcher, A., Horn, S. S., Moberg, P. J., Wilkinson, J. R., Hurtig, H. I., Stern, M. B., et al. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02096.x · Cited by 304 · see citing works
Maidan, I., Nieuwhof, F., Bernad‐Elazari, H., Reelick, M. F., Bloem, B. R., Giladi, N., Deutsch, J. E., Hausdorff, J. M., Claassen, J. A. H. R., & Mirelman, A. (2016) · Neurorehabilitation and neural repair · doi:10.1177/1545968316650426 · Cited by 304 · see citing works
How might physical activity benefit patients with Parkinson disease?
Speelman, A. D., van de Warrenburg, B. P. C., van Nimwegen, M., Petzinger, G. M., Munneke, M., & Bloem, B. R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.107 · Cited by 285 · see citing works
REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia
Vendette, M., Gagnon, J., Décary, A., Massicotte-Marquez, J., Postuma, R. B., Doyon, J., Panisset, M., & Montplaisir, J. Y. (2007) · Neurology · doi:10.1212/01.wnl.0000278114.14096.74 · Cited by 281 · see citing works
The ongoing pursuit of neuroprotective therapies in Parkinson disease
Athauda, D. S., & Foltynie, T. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.226 · Cited by 267 · see citing works
Cognitive performance of GBA mutation carriers with early-onset PD
Alcalay, R. N., Caccappolo, E., Mejia‐Santana, H., Tang, M. X., Rosado, L., Reilly, M. O., Ruiz, D., Ross, B., Verbitsky, M., Kisselev, S., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318253d54b · Cited by 266 · see citing works
Cognitive impairment and dementia in Parkinson's disease
Pagonabarraga, J., & Kulisevsky, J. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.029 · Cited by 257 · see citing works
Functional brain networks and cognitive deficits in Parkinson's disease
Baggio, H. C., Sala‐Llonch, R., Segura, B., Martı́, M. J., Valldeoriola, F., Compta, Y., TOLOSA, E. S., & Junqué, C. (2014) · Human Brain Mapping · doi:10.1002/hbm.22499 · Cited by 246 · see citing works
Cognitive impairment in Parkinson's disease
Verbaan, D., Marinus, J., Jeukens‐Visser, M., van Rooden, S. M., Stiggelbout, A. M., Middelkoop, H. A. M., & van Hilten, J. J. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.112367 · Cited by 240 · see citing works
The clinical heterogeneity of Parkinson's disease and its therapeutic implications
Greenland, J. C., Williams‐Gray, C. H., & Barker, R. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14094 · Cited by 239 · see citing works
Cognitive function in early Parkinson’s disease: a population‐based study
Elgh, E., Domellöf, M., Linder, J., Edström, M., Stenlund, H. C., & Forsgren, L. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02707.x · Cited by 235 · see citing works
Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease
Volkmann, J., Daniels, C., & Witt, K. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.111 · Cited by 232 · see citing works
The expanding universe of disorders of the basal ganglia
Obeso, J. A., Rodríguez‐Oroz, M., Stamelou, M., Bhatia, K. P., & Burn, D. J. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62418-6 · Cited by 232 · see citing works
Global scales for cognitive screening in Parkinson's disease: Critique and recommendations
Škorvánek, M., Goldman, J. G., Jahanshahi, M., Marras, C., Rektorová, I., Schmand, B. A., van Duijn, E., Goetz, C. G., Weintraub, D. A., Stebbins, G. T., et al. (2017) · Movement Disorders · doi:10.1002/mds.27233 · Cited by 231 · see citing works
Self-citationNeurotransmission in Parkinson’s disease: beyond dopamine
Barone, P. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02900.x · Cited by 222 · see citing works
Alves, G. W., Brønnick, K., Aarsland, D., Blennow, K., Zetterberg, H., Ballard, C. G., Kurz, M. W., Andréasson, U., Tysnes, O., Larsen, J. O., et al. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.199950 · Cited by 221 · see citing works
Cueing for freezing of gait in patients with Parkinson's disease: A rehabilitation perspective
Nieuwboer, A. (2008) · Movement Disorders · doi:10.1002/mds.21978 · Cited by 219 · see citing works
Physical exercise for people with Parkinson’s disease: a systematic review and network meta-analysis
Ernst, M., Folkerts, A., Gollan, R., Lieker, E., Caro-Valenzuela, J., Adams, A., Cryns, N., Monsef, I., Dresen, A., Roheger, M., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013856.pub2 · Cited by 231 · see citing works
Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementia
Kulisevsky, J., Pagonabarraga, J., Pascual‐Sedano, B., García‐Sánchez, C., Gironell, A., & Trapecio Group Study (2008) · Movement Disorders · doi:10.1002/mds.22246 · Cited by 216 · see citing works
Hanganu, A., Bedetti, C., Degroot, C., Mejia‐Constain, B., Lafontaine, A., Soland, V., Chouinard, S., Bruneau, M., Mellah, S., Belleville, S., et al. (2014) · Brain · doi:10.1093/brain/awu036 · Cited by 214 · see citing works
Mild Cognitive Impairment in Parkinson’s Disease
Aarsland, D., Brønnick, K., & Fladby, T. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0203-1 · Cited by 213 · see citing works
GBA Variants are associated with a distinct pattern of cognitive deficits in P arkinson's disease
Mata, I. F., Leverenz, J. B., Weintraub, D. A., Trojanowski, J. Q., Chen‐Plotkin, A. S., Deerlin, V. M. V., Ritz, B. R., Rausch, R., Factor, S. A., Wood‐Siverio, C., et al. (2015) · Movement Disorders · doi:10.1002/mds.26359 · Cited by 203 · see citing works
Visual symptoms in Parkinson's disease and Parkinson's disease dementia
Archibald, N. K., Clarke, M. P., Mosimann, U. P., & Burn, D. J. (2011) · Movement Disorders · doi:10.1002/mds.23891 · Cited by 207 · see citing works
APOE,MAPT, andSNCAGenes and Cognitive Performance in Parkinson Disease
Mata, I. F., Leverenz, J. B., Weintraub, D. A., Trojanowski, J. Q., Hurtig, H. I., Deerlin, V. M. V., Ritz, B. R., Rausch, R., Rhodes, S. L., Factor, S. A., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1455 · Cited by 203 · see citing works
Resting state oscillatory brain dynamics in Parkinson’s disease: An MEG study
Bosboom, J. L. W., Stoffers, D., Stam, C. J., van Dijk, B. W., Verbunt, J. P. A., Berendse, H. W., & Wolters, E. C. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.06.720 · Cited by 201 · see citing works
Evolution of mild cognitive impairment in Parkinson disease
Broeders, M., de Bie, R. M. A., Velseboer, D. C., Speelman, J. D., Muslimović, D., & Schmand, B. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31829c5c86 · Cited by 201 · see citing works
Self-citationBenedict, R., Ramasamy, D., Munschauer, F., Weinstock-Guttman, B., & Zivadinov, R. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.148403 · Cited by 198 · see citing works
Mamikonyan, E., Moberg, P. J., Siderowf, A., Duda, J. E., Have, T. T., Hurtig, H. I., Stern, M. B., & Weintraub, D. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.05.006 · Cited by 192 · see citing works
Amboni, M., Tessitore, A., Esposito, F., Santangelo, G., Picillo, M., Vitale, C., Giordano, A., Erro, R., Micco, R. D., Corbo, D., et al. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7591-5 · Cited by 192 · see citing works
Bocanegra, Y., García, A. M., Pineda, D. A., Buriticá, O., Villegas, A., Lopera, F. J., Gómez, D., Gómez-Arias, C., Cardona, J. F., Trujillo, N., et al. (2015) · Cortex · doi:10.1016/j.cortex.2015.05.022 · Cited by 190 · see citing works
da Silva, F. C., Iop, R. D. R., de Oliveira, L. C., Boll, A. M., de Alvarenga, J. G. S., Gutierres Filho, P. J. B., de Melo, L. M. A. B., Xavier, A. J., & da Silva, R. (2018) · PLOS ONE · doi:10.1371/journal.pone.0193113 · Cited by 189 · see citing works
Riedel, O., Klotsche, J., Spottke, A., Deuschl, G., Förstl, H., Henn, F., Heuser, I., Oertel, W., Reichmann, H., Riederer, P., et al. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0720-2 · Cited by 254 · see citing works
Cognitive impairment in Parkinson's disease: Tools for diagnosis and assessment
Kulisevsky, J., & Pagonabarraga, J. (2009) · Movement Disorders · doi:10.1002/mds.22506 · Cited by 188 · see citing works
Cognitive impairments in multiple system atrophy
Kawai, Y., Suenaga, M., Takeda, A., Ito, M., Watanabe, H., Tanaka, F., Kato, K., Fukatsu, H., Naganawa, S., Kato, T., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000310413.04462.6a · Cited by 187 · see citing works
DTI correlates of distinct cognitive impairments in Parkinson's disease
Zheng, Z. S., Shemmassian, S. K., Wijekoon, C., Kim, W. B., Bookheimer, S. Y., & Pouratian, N. (2013) · Human Brain Mapping · doi:10.1002/hbm.22256 · Cited by 179 · see citing works
Prefrontal dopamine signaling and cognitive symptoms of Parkinson’s disease
Narayanan, N. S., Rodnitzky, R. L., & Uc, E. Y. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0004 · Cited by 176 · see citing works
Ekman, U., Eriksson, J., Forsgren, L., Mo, S. J., Riklund, K., & Nyberg, L. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70138-2 · Cited by 172 · see citing works
Meireles, J., & Massano, J. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00088 · Cited by 172 · see citing works
Tröster, A. I. (2008) · Neuropsychology Review · doi:10.1007/s11065-008-9055-0 · Cited by 173 · see citing works
Recent advances in rehabilitation for Parkinson’s Disease with Exergames: A Systematic Review
García-Agúndez, A., Folkerts, A., Konrad, R., Caserman, P., Tregel, T., Gooßes, M., Göbel, S. P., & Kalbe, E. (2019) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-019-0492-1 · Cited by 171 · see citing works
Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients
Witt, J., & Helmstaedter, C. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6526-2 · Cited by 168 · see citing works
Motor procedural learning in Parkinson's disease
Muslimović, D., Post, B., Speelman, J. D., & Schmand, B. A. (2007) · Brain · doi:10.1093/brain/awm211 · Cited by 163 · see citing works
Self-citationAttentional control in Parkinson's disease is dependent on COMT val158met genotype
Williams‐Gray, C. H., Hampshire, A., Barker, R., & Owen, A. M. (2008) · Brain · doi:10.1093/brain/awm313 · Cited by 165 · see citing works
A process-model based approach to prospective memory impairment in Parkinson's disease
Kliegel, M., Altgassen, M., Hering, A., & Rose, N. S. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.01.024 · Cited by 163 · see citing works
Irwin, D. J., & Hurtig, H. I. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000444 · Cited by 165 · see citing works
Action and object naming in Parkinson's disease without dementia
Cotelli, M., Borroni, B., Manenti, R., Zanetti, M., Arévalo, A. L., Cappa, S. F., & Padovani, A. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01797.x · Cited by 161 · see citing works
Poletti, M., Frosini, D., Pagni, C., Baldacci, F., Nicoletti, V., Tognoni, G., Lucetti, C., Dotto, P. D., Ceravolo, R., & Bonuccelli, U. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301874 · Cited by 160 · see citing works
Characteristics of executive function impairment in Parkinson’s disease patients without dementia
McKinlay, A., Grace, R. C., Dalrymple‐Alford, J. C., & Roger, D. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709991299 · Cited by 161 · see citing works
Brønnick, K. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.093146 · Cited by 160 · see citing works
Mild cognitive impairment as a risk factor for Parkinson's disease dementia
Hoogland, J., Boel, J. A., de Bie, R. M. A., Geskus, R. B., Schmand, B. A., Dalrymple‐Alford, J. C., Marras, C., Adler, C. H., Goldman, J. G., Tröster, A. I., et al. (2017) · Movement Disorders · doi:10.1002/mds.27002 · Cited by 158 · see citing works
Self-citationCognitive decline in Parkinson’s disease: A prospective longitudinal study
Muslimović, D., Post, B., Speelman, J. D., de Haan, R. J., & Schmand, B. A. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709090614 · Cited by 155 · see citing works
Self-citationGray and white matter imaging: A biomarker for cognitive impairment in early P arkinson's disease?
Duncan, G. W., Firbank, M., Yarnall, A. J., Khoo, T. K., Brooks, D. J., Barker, R. A., Burn, D. J., & O'Brien, J. T. (2015) · Movement Disorders · doi:10.1002/mds.26312 · Cited by 154 · see citing works
Dubbelink, K. T. E. O., Stoffers, D., Deijen, J. B., Twisk, J. W. R., Stam, C. J., & Berendse, H. W. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.029 · Cited by 154 · see citing works
Rosenthal, E. W., Brennan, L., Xie, S. X., Hurtig, H. I., Milber, J. M., Weintraub, D. A., Karlawish, J. H., & Siderowf, A. D. (2010) · Movement Disorders · doi:10.1002/mds.23073 · Cited by 153 · see citing works
Mild cognitive impairment in Parkinson's disease.
Goldman, J. G., & Litvan, I. (2011) · PubMed · Cited by 152 · see citing works
Cut‐off score of the Mattis Dementia Rating Scale for screening dementia in Parkinson's disease
Llebaria, G., Pagonabarraga, J., Kulisevsky, J., García‐Sánchez, C., Pascual‐Sedano, B., Gironell, A., & Martínez‐Corral, M. (2008) · Movement Disorders · doi:10.1002/mds.22173 · Cited by 150 · see citing works
Course of cognitive decline in Parkinson's disease: A meta-analysis
Muslimović, D., Schmand, B. A., Speelman, J. D., & de Haan, R. J. (2007) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617707071160 · Cited by 148 · see citing works
Self-citationMild Cognitive Impairment in newly diagnosed Parkinson's disease: A longitudinal prospective study
Santangelo, G., Vitale, C., Picillo, M., Moccia, M., Cuoco, S., Longo, K., Pezzella, D., di Grazia, A., Erro, R., Pellecchia, M. T., et al. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.08.024 · Cited by 149 · see citing works
García, A. M., Carrillo, F., Orozco-Arroyave, J. R., Trujillo, N., Vargas Bonilla, J. F., Fittipaldi, S., Adolfi, F., Nöth, E., Sigman, M., Fernández Slezak, D., et al. (2016) · Brain and Language · doi:10.1016/j.bandl.2016.07.008 · Cited by 144 · see citing works
Cognitive function in the early phase of Parkinson's disease, a five-year follow-up
Domellöf, M., Ekman, U., Forsgren, L., & Elgh, E. (2015) · Acta Neurologica Scandinavica · doi:10.1111/ane.12375 · Cited by 147 · see citing works
Nombela, C., Rowe, J. B., Winder‐Rhodes, S., Hampshire, A., Owen, A. M., Breen, D. P., Duncan, G. W., Khoo, T. K., Yarnall, A. J., Firbank, M., et al. (2014) · Brain · doi:10.1093/brain/awu201 · Cited by 146 · see citing works
High-Level Language Production in Parkinson's Disease: A Review
Altmann, L. J. P., & Troche, M. S. (2011) · Parkinson s Disease · doi:10.4061/2011/238956 · Cited by 145 · see citing works
Awareness and current knowledge of Parkinson’s disease: a neurodegenerative disorder
Khan, A. U., Akram, M., Daniyal, M., & Zainab, R. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1486837 · Cited by 145 · see citing works
The spectrum of cognitive impairment in Lewy body diseases
Goldman, J. G., Williams‐Gray, C. H., Barker, R. A., Duda, J. E., & Galvin, J. E. (2014) · Movement Disorders · doi:10.1002/mds.25866 · Cited by 142 · see citing works
Training of executive functions in Parkinson's disease
Sammer, G., Reuter, I., Hullmann, K., Kaps, M., & Vaitl, D. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.05.028 · Cited by 141 · see citing works
Moving from physician-centered care towards patient-centered care for Parkinson's disease patients
van der Eijk, M., Nijhuis, F. A. P., Faber, M. J., & Bloem, B. R. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.04.022 · Cited by 138 · see citing works
Characterizing mild cognitive impairment in Parkinson's disease
Dalrymple‐Alford, J. C., Livingston, L., MacAskill, M. R., Graham, C., Melzer, T. R., Porter, R., Watts, R., & Anderson, T. (2011) · Movement Disorders · doi:10.1002/mds.23592 · Cited by 137 · see citing works
- Authors
- Muslimović, D., Post, B., Speelman, J. D., & Schmand, B.
- Affiliations
- From the Department of Neurology, Academic Medical Center, University of Amsterdam, the Netherlands; and CARPA Study Group (Drs. Post and Speelman).
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Neurology
- Published
- 2005-10-25
- Volume
- 65
- Issue
- 8
- Pages
- 1239-1245
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2131881760
- Cited by
- 1,007
- References
- 29
- Citations by year
- 2026: 18 · 2025: 35 · 2024: 30 · 2023: 31 · 2022: 48 · 2021: 58 · 2020: 48 · 2019: 57 · 2018: 57 · 2017: 58 · 2016: 54 · 2015: 67 · 2014: 71 · 2013: 82 · 2012: 62
- FWCI
- 16.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, cognitive impairment, executive function, memory impairment, psychomotor speed, age of onset, neuropsychological assessment, newly diagnosed patients
- MeSH terms
- Affective Symptoms, Aged, Cognition Disorders, Female, Humans, Language Disorders, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Parkinson Disease, Predictive Value of Tests, Psychomotor Performance, Cohort Studies, Comorbidity, Prevalence, Age of Onset
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