Cited by 428Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSchizophrenia research and treatment

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype

Meyer-Lindenberg, Andreas, Kohn, Philip D, Kolachana, Bhaskar, Kippenhan, Shane, McInerney-Leo, Aideen, Nussbaum, Robert, Weinberger, Daniel R, Berman, Karen Faith·2005·Nature Neuroscience

Abstract

Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopamine synthesis in midbrain and qualitatively affected the interaction with prefrontal cortex. These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT.

Integrity signals

Registry

Crossref · 10.1038/nn1438

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The inverted U-shape model of prefrontal cortical dopamine levels and function might also operate in the striatum.

    “and indicates that the established inverted U-shape model of prefrontal cortical dopamine levels and function (and consequently neurocognitive performance), might also operate in the striatum.51-53”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Meyer-Lindenberg, A., Kohn, P. D., Kolachana, B., Kippenhan, S., McInerney-Leo, A., Nussbaum, R., Weinberger, D. R., & Berman, K. F.
Affiliations
National Institutes of Health (US)
Venue
Nature Neuroscience
Published
2005-04-10
Volume
8
Issue
5
Pages
594-596
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1993105546
Cited by
428
References
15
Citations by year
2026: 7 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 16 · 2020: 13 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 28 · 2015: 21 · 2014: 25 · 2013: 35 · 2012: 37
FWCI
12.54
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
midbrain dopamine, prefrontal cortex, catechol-O-methyltransferase, COMT genotype, dopamine synthesis, gene-environment interaction, cognitive function, neuropsychiatric disorders
MeSH terms
Adult, Brain Mapping, Catechol O-Methyltransferase, Cognition, Dopamine, Feedback, Female, Genotype, Humans, Male, Memory, Short-Term, Mesencephalon, Metabolic Clearance Rate, Neural Pathways, Synaptic Transmission, Neuropsychological Tests, Reaction Time, Prefrontal Cortex, Amino Acid Substitution, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review