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Head injury and risk of Parkinson disease: A systematic review and meta‐analysis
Abstract
Head trauma has been implicated in the etiopathogenesis of Parkinson's disease (PD). We performed a meta‐analysis to investigate the association between head trauma and the risk of developing PD. We included observational studies if they (1) clearly defined PD, (2) defined head trauma leading to concussion, and (3) presented odds ratios (ORs) and 95% confidence intervals (CIs) or provided data to compute these statistics. Random effect model was used to estimate the pooled, adjusted OR. Heterogeneity between studies was evaluated with the Q test and the I 2 statistic. We conducted a sensitivity analysis to assess the influence of each study and repeated the analysis by excluding the studies with the largest weights. We used funnel plot to assess the presence of publication bias. After reviewing more than 636 article titles, 34 articles were selected for full review. In total, 22 studies (19 case–control studies, 2 nested case–control studies, and 1 cohort study) were included in the meta‐analysis. The pooled OR for the association of PD and head trauma was 1.57 (95% CI, 1.35–1.83). The results of our meta‐analysis indicate that a history of head trauma that results in concussion is associated with a higher risk of developing PD. © 2013 Movement Disorder Society
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“In particular, repeated mTBI (rmTBI) has been identified as a major risk factor for neurodegenerative diseases including Alzheimer’s disease (AD) [100], Parkinson’s disease (PD) [68] amyotrophic lateral sclerosis (ALS) [21, 2], fronto-temporal dementia (FTD) [126, 124], and chronic traumatic encephalopathy (CTE) [95].”
From Early onset senescence and cognitive impairment in a murine model of repeated mTBI (2021) · cites this paper as [68]
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Metadata
- Authors
- Jafari, S., Etminan, M., Aminzadeh, F., & Samii, A.
- Affiliations
- University of British Columbia (CA)
- St. George's University School of Medicine Newcastle United Kingdom
- University of Washington (US)
- Corresponding author
- Samii, Ali
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2013-04-22
- Volume
- 28
- Issue
- 9
- Pages
- 1222-1229
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2149187987
- Cited by
- 282
- References
- 48
- Citations by year
- 2026: 18 · 2025: 16 · 2024: 20 · 2023: 26 · 2022: 25 · 2021: 27 · 2020: 29 · 2019: 24 · 2018: 20 · 2017: 27 · 2016: 14 · 2015: 22 · 2014: 11 · 2013: 3
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- Parkinson's disease, head trauma, concussion, risk factors, etiopathogenesis, traumatic brain injury
- MeSH terms
- Craniocerebral Trauma, Parkinson Disease, Confidence Intervals, Case-Control Studies, Databases, Factual
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