Changes in the cell population in brain white matter in multiple system atrophy
Abstract
Background: M ultiple system atrophy (MSA) is a sporadic progressive neurodegenerative disorder with adult onset and unknown etiology. Clinically it is characterized by autonomic failure, cerebellar ataxia, parkinsonism, and corticospinal dysfunction in any combination and with varying severity. Objectives and Methods: T o establish the extent of involvement of the white matter in the disease, we have used stereology to quantify the total number of neurons and glial cells (oligodendrocytes, astrocytes, and microglia) in the brains from 10 MSA patients and 11 controls. Results: T he mean total number of white matter interstitial neurons in the patient brains was 0.5 × 10 9 (coefficient of variation = standard deviation/mean = 0.37), which was significantly lower than the 1.1 × 10 9 (0.41) in the control brains (P = .001) and equal to a reduction by ∼50%. The patient brains had a significantly higher number of white matter microglia, 1.5 × 10 9 (0.47) versus 0.7 × 10 9 (0.39) microglia in the control subjects (P = .003) and equal to an increase by ∼ 100%. There was no significant difference in mean total numbers of white matter oligodendrocytes and astrocytes between the groups. Conclusions: We found widespread microgliosis without concomitant astrogliosis in brain white matter in MSA patients and demonstrated an absence of significant oligodendrocyte degeneration. The exact role of oligodendrocytes in MSA pathogenesis, including neurodegeneration, remains to be elucidated. © 2017 International Parkinson and Movement Disorder Society
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According to pathological studies and PET imaging of MSA brains, microglial activation and neuroinflammation constitute important features of MSA.
“But according to pathological studies and PET imaging of MSA brains, microglial activation and neuroinflammation constitute important features of MSA.283–287”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [285]
Significant widespread microgliosis occurs in both neocortex and white matter in MSA patients compared with controls.
“The results showed significant widespread microgliosis in both neocortex and white matter in MSA patients compared with controls.284,285”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [285]
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- Authors
- Nykjær, C. H., Brudek, T., Salvesen, L., & Pakkenberg, B.
- Affiliations
- Frederiksberg Hospital (DK)
- University of Copenhagen (DK)
- Corresponding author
- Pakkenberg, Bente
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2017-04-10
- Volume
- 32
- Issue
- 7
- Pages
- 1074-1082
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2605554476
- Cited by
- 51
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 3 · 2016: 1
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Lundbeckfonden (R126-2012-12359)
- Novo Nordisk Fonden (NNF15OC0017008)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- multiple system atrophy, white matter, microglial activation, oligodendrocytes, astrocytes, microglia, neurodegeneration, stereology, oligodendrocyte degeneration
- MeSH terms
- Aged, Cell Count, Female, Humans, Male, Middle Aged, Neuroglia, Neurons, Multiple System Atrophy, White Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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