Development of the Cell Population in the Brain White Matter of Young Children
Abstract
While brain gray matter is primarily associated with sensorimotor processing and cognition, white matter modulates the distribution of action potentials, coordinates communication between different brain regions, and acts as a relay for input/output signals. Previous studies have described morphological changes in gray and white matter during childhood and adolescence, which are consistent with cellular genesis and maturation, but corresponding events in infants are poorly documented. In the present study, we estimated the total number of cells (neurons, oligodendrocytes, astrocytes, and microglia) in the cerebral white matter of 9 infants aged 0-33 months, using design-based stereological methods to obtain quantitative data about brain development. There were linear increases with age in the numbers of oligodendrocytes (7-28 billion) and astrocytes (1.5-6.7 billion) during the first 3 years of life, thus attaining two-thirds of the corresponding numbers in adults. The numbers of neurons (0.7 billion) and microglia (0.2 billion) in the white matter did not increase during the first 3 years of life, but showed large biological variation.
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The number of oligodendrocytes in cerebral white matter increases rapidly and linearly after birth, from about seven billion at birth to 28 billion at age three, a rate of 600 million per month.
“the number of oligodendrocytes in cerebral white matter increases rapidly and linearly after birth, from approximately 7 billion at birth to 28 billion at age 3 years — a rate of 600 million per month216.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [216]
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- Authors
- Sigaard, R. K., Kjær, M., & Pakkenberg, B.
- Affiliations
- Frederiksberg Hospital (DK)
- Corresponding author
- Sigaard, Rasmus Krarup
- ORCID
- Pakkenberg, Bente
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-08-13
- Volume
- 26
- Issue
- 1
- Pages
- 89-95
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2114272337
- Cited by
- 43
- References
- 47
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Keywords
- white matter, infant brain development, oligodendrocytes, astrocytes, microglia, neurons, cell number, stereology, early childhood
- MeSH terms
- Age Factors, Astrocytes, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Oligodendroglia, Microglia, Cell Proliferation, White Matter
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