Widespread microglial activation in multiple system atrophy
Open accessAbstract
Background: The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [ 11 C] (R) ‐PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients. Methods: Fourteen patients with the parkinsonian phenotype of MSA (MSA‐P) with a mean disease duration of 2.9 years (range 2‐5 years) were examined with [ 11 C] (R) ‐PK11195 PET and compared with 10 healthy controls. Results: Patients with the parkinsonian phenotype of MSA showed a significant ( P ≤ 0.01) mean increase in binding potentials compared with healthy controls in the caudate nucleus, putamen, pallidum, precentral gyrus, orbitofrontal cortex, presubgenual anterior cingulate cortex, and the superior parietal gyrus. No correlations between binding potentials and clinical parameters were found. Conclusions: In early clinical stages of the parkinsonian phenotype of MSA, there is widespread microglial activation as a marker of neuroinflammatory changes without correlation to clinical parameters in our patient population. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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Widespread microglial activation occurs early in the clinical stage of MSA.
“suggesting widespread microglial activation occurs early in the clinical stage of MSA.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [286]
PET imaging demonstrated microglial activation in the brains of patients with MSA.
“PET imaging also demonstrated microglial activation in the brains of patients with MSA.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [286]
In a [11C](R)-PK11195 PET study, MSA-P patients had significantly higher binding potentials in the precentral gyrus, caudate nucleus, putamen, pallidum, orbitofrontal cortex, superior parietal gyrus and presubgenual anterior cingulate cortex than controls.
“it was found that MSA-P patients had significantly higher binding potentials in the precentral gyrus, caudate nucleus, putamen, pallidum, orbitofrontal cortex, superior parietal gyrus and presubgenual anterior cingulate cortex than controls.286”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [286]
According to pathological studies and PET imaging of MSA brains, microglial activation and neuroinflammation constitute important features of MSA.
“But according to pathological studies and PET imaging of MSA brains, microglial activation and neuroinflammation constitute important features of MSA.283–287”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [286]
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- Authors
- Kübler, D., Wächter, T., Cabanel, N., Su, Z., Turkheimer, F. E., Dodel, R., Brooks, D. J., Oertel, W. H., & Gerhard, A.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Vitos (DE)
- Salford Royal NHS Foundation Trust (GB)
- King's College London (GB)
- Essen University Hospital (DE)
- Aarhus University (DK)
- Philipps University of Marburg (DE)
- University of Manchester (GB)
- Corresponding author
- Kübler, Dorothee
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2019-02-06
- Volume
- 34
- Issue
- 4
- Pages
- 564-568
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC6659386
- OpenAlex
- W2913658966
- Cited by
- 61
- References
- 27
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 9 · 2021: 9 · 2020: 13 · 2019: 2
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Movement Disorders (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Site cant be reached (submittedVersion, cc-by-nc-nd)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Action Research (SP 3615)
- European Union's Seventh Framework Program (HEALTH-F2-2011-278850 (INMiND))
- Parkinson's Disease Society UK (MAP 02/04)
- Charitable Hertie Foundation, Frankfurt, Germany
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- multiple system atrophy, microglial activation, [11C]PK11195 PET, neuroinflammation, caudate nucleus, putamen, globus pallidus, orbitofrontal cortex, superior parietal gyrus, early-stage disease, clinical correlates
- MeSH terms
- Aged, Brain, Female, Humans, Male, Middle Aged, Microglia, Multiple System Atrophy, Positron-Emission Tomography
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