Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
Open accessAbstract
Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions (GCIs) rich in α-synuclein (α-syn) constitute the disease hallmark, accompanied by neuronal loss and activation of glial cells which indicate neuroinflammation. Recent studies demonstrate that α-syn may be released from degenerating neurons to mediate formation of abnormal inclusion bodies and to induce neuroinflammation which, interestingly, might also favor the formation of intracellular α-syn aggregates as a consequence of cytokine release and the shift to a pro-inflammatory environment. Here, we critically review the relationships between α-syn and astrocytic and microglial activation in MSA to explore the potential of therapeutics which target neuroinflammation.
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α-syn species are believed to activate microglial cells, accelerating neurodegeneration in MSA.
“However, α-syn species are believed to activate microglial cells, accelerating neurodegeneration in MSA.290”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [290]
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Quantitative cellular changes in multiple system atrophy brains
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α‐Synuclein activates innate immunity but suppresses interferon‐γ expression in murine astrocytes
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Multiple system atrophy pathology is associated with primary Sjögren’s syndrome
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The Peripheral Immune Traits Changed in Patients with Multiple System Atrophy
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- Authors
- Vieira, B. D. M., Radford, R. A., Chung, R. S., Guillemin, G. J., & Pountney, D. L.
- Affiliations
- Griffith University (AU)
- Macquarie University (AU)
- Corresponding author
- Pountney, Dean L.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-11-12
- Volume
- 9
- Pages
- 437-437
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4700780
- OpenAlex
- W2174469825
- Cited by
- 93
- References
- 118
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 5 · 2021: 7 · 2020: 11 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Griffith University
- Menzies Health Institute Queensland
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- multiple system atrophy, neuroinflammation, alpha-synuclein aggregation, astrocyte activation, microglial activation, glial activation, cytokine production, neurodegeneration
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