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The metabolic anatomy of Parkinson's disease: Complementary [18F]fluorodeoxyglucose and [18F]fluorodopa positron emission tomographic studies
Abstract
We studied the metabolic anatomy of typical Parkinson's disease (PD) using [18 F]fluorodeoxyglucose (FDG) and [18 F]fluorodopa (FDOPA) and positron emission tomography (PET). Fourteen PD patients (mean age 49 years) had FDG/PET scans, of which 11 were scanned with both FDOPA and FDG. After the injection of FDOPA, brain uptake and arterial plasma radioactivity were monitored for 2 h. Striatal FDOPA uptake was analyzed with regard to a two‐compartment model, and target‐to‐background ratios (TBRs) and TBR‐versus‐time slopes were also calculated. Regional patterns of metabolic covariation were extracted from FDG/PET data using the Scaled Subprofile Model (SSM). SSM pattern weights, FDOPA uptake constants (Ki), TBRs, and TBR slopes were correlated with clinical measures for bradykinesia, rigidity, tremor, gait disturbance, left‐right asymmetry, dementia, and overall disease severity. In PD patients, rate constants for FDOPA uptake correlated with individual measures of bradykinesia (p = 0.001) and gait disability (p < 0.05). SSM analysis revealed a distinct pattern of regional metabolic asymmetries, which correlated with motor asymmetries (p < 0.001) and left‐right differences in Ki (p < 0.01). Our data suggest that in PD patients, FDG/PET and FDOPA/PET may provide unique and complementary information about underlying disease processes.
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Cites
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
Cited by
The metabolic topography of parkinsonism
Eidelberg, D., Moeller, J. R., Dhawan, V., Spetsieris, P., Takikawa, S., Ishikawa, T., Chaly, T., Robeson, W., Margouleff, D., Przedborski, S., et al. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.99 · Cited by 455
Self-citationThe metabolic topography of normal aging
Moeller, J. R., Ishikawa, T., Dhawan, V., Spetsieris, P., Mandel, F., Alexander, G. E., Grady, C., Pietrini, P., & Eidelberg, D. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199605000-00005 · Cited by 254
Self-citationBlinded positron emission tomography study of dopamine cell implantation for Parkinson's disease
Nakamura, T., Dhawan, V., Chaly, T., Fukuda, M., Ma, Y., Breeze, R., Greene, P., Fahn, S., Freed, C., & Eidelberg, D. (2001) · Annals of Neurology · doi:10.1002/ana.1075 · Cited by 67
Self-citationRett Syndrome: Investigation of Nine Patients, including PET Scan
Dunn, H. G., Stoessl, A. J., Ho, H. H., MacLeod, P. M., Poskitt, K. J., Doudet, D. J., Schulzer, M., Blackstock, D., Dobko, T., Koop, B., et al. (2002) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100002213 · Cited by 32
Visualizing the evolution of abnormal metabolic networks in the brain using PET
Spetsieris, P. G., Moeller, J. R., Dhawan, V., Ishikawa, T., & Eidelberg, D. (1995) · Computerized Medical Imaging and Graphics · doi:10.1016/0895-6111(95)00011-e · Cited by 23
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Metadata
- Authors
- Eidelberg, D., Moeller, J. R., Dhawan, V., Sidtis, J. J., Ginos, J. Z., Strother, S. C., Cedarbaum, J., Greene, P., Fahn, S., & Rottenberg, D. A.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 1990-01
- Volume
- 5
- Issue
- 3
- Pages
- 203-213
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2016715200
- Cited by
- 204
- References
- 2
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eidelberg, D., Moeller, J. R., Dhawan, V., Sidtis, J. J., Ginos, J. Z., Strother, S. C., Cedarbaum, J., Greene, P., Fahn, S., & Rottenberg, D. A. (1990). The metabolic anatomy of Parkinson's disease: Complementary [18F]fluorodeoxyglucose and [18F]fluorodopa positron emission tomographic studies. Movement Disorders. https://doi.org/10.1002/mds.870050304
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