Oxidative stress-a key emerging impact factor in health, ageing, lifestyle and aesthetics
Open accessAbstract
Oxidative stress is the resultant damage that arises due to redox imbalances, more specifically an increase in destructive free radicals and reduction in protection from antioxidants and the antioxidant defence pathways. Oxidation of lipids by reactive oxygen species (ROS) can damage cellular structures and result in premature cell death. At low levels, ROS-induced oxidative stress can be prevented through the action of antioxidants, however, when ROS are present in excess, inflammation and cytotoxicity eventually results leading to cellular oxidative stress damage. Increasing evidence for the role of oxidative stress in various diseases including neurological, dermatological, and cardiovascular diseases is now emerging. Mitochondria are the principal source (90%) of ROS in the cell, with superoxide radicals being generated when molecular oxygen is combined with free electrons. Given the key role of mitochondria in the generation of cellular oxidative stress it is worth considering this organelle and the process in more detail and to provide methods of intervention.
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In vivo oxidation eventually leads to aging of the organism, so exogenous antioxidant supplements, with food being an important source, have become a topic of research.
“In vivo oxidation eventually leads to aging of the organism, so exogenous antioxidant supplements, with food being an important source, have become a topic of research [107].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [107]
ROS can cause various cardiovascular diseases, cancers, and aging.
“ROS can cause various cardiovascular diseases, cancers, and aging.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [107]
Mitochondria are considered the predominant source of intracellular ROS and are believed to contribute 90% of the ROS generated within the cell.
“Mitochondria are considered to be the predominant source of intracellular ROS and are believed to contribute 90% of the ROS generated within the cell [8].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [8]
Mitochondrial DNA is particularly vulnerable to damage following UVR exposure as mitochondria have limited DNA repair mechanisms.
“Mitochondrial DNA is particularly vulnerable to damage following exposure to UVR as mitochondria have limited DNA repair mechanisms [8].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [8]
UVR increases oxidative stress by both direct and indirect means, either by potent stimulation of ROS or by direct DNA damage.
“UVR is therefore able to increase oxidative stress by both direct and indirect means, either by potent stimulation of ROS or by direct DNA damage [8].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [8]
Diet is an important source of exogenously derived antioxidants.
“Recently there has been considerable interest in the effects of diet on oxidative stress due to the diet being an important source of exogenously derived antioxidants [8].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [8]
UVR may increase ROS levels, or cause mtDNA damage directly, which could result in an increase in mitochondrial dysfunction and a further production of ROS in a continuing vicious cycle and a putative increase in photoageing.
“UVR may increase ROS levels, or cause mtDNA damage directly, which could result in an increase in mitochondrial dysfunction and a further production of ROS in a continuing vicious cycle and a putative increase in photoageing, as mitochondria are thought to play a prominent role in this process [Kandola et al., 2015].”
From Oxidative stress and ageing (2016) · cites this paper as Kandola et al., 2015
UVR is the main extrinsic influence of skin ageing; either by the production of ROS or via direct DNA damage.
“UVR is the main extrinsic influence of skin ageing [Kandola et al., 2015; Oyewole et al., 2013]; either by the production of ROS or via direct DNA damage.”
From Oxidative stress and ageing (2016) · cites this paper as Kandola et al., 2015
Within this theory the Vicious Cycle Theory of Ageing was included which proposes that ROS production from the mitochondrial ETC is able to cause damage to the mtDNA found in close proximity.
“Within this theory the Vicious Cycle Theory of Ageing was included which proposes that ROS production from the mitochondrial ETC is able to cause damage to the mtDNA found in close proximity.”
From Oxidative stress and ageing (2016) · cites this paper as Kandola et al., 2015
Dysfunctional mitochondria are then thought to contribute to further ROS leakage due to their inefficiency, which could then exacerbate mtDNA damage in a continuing vicious cycle.
“Dysfunctional mitochondria are then thought to contribute to further ROS leakage due to their inefficiency, which could then exacerbate mtDNA damage in a continuing vicious cycle [Bandy and Davison 1990, Kandola et al., 2015].”
From Oxidative stress and ageing (2016) · cites this paper as Kandola et al., 2015
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Hu, Q., Liu, Z., Guo, Y., Lu, S., Du, H., & Cao, Y. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114398 · Cited by 139 · see citing works
Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin
Naidoo, K., & Birch-Machin, M. (2017) · Cosmetics · doi:10.3390/cosmetics4010004 · Cited by 83 · see citing works
Self-citationSkin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System
Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49 · see citing works
Mitochondrial damage and ageing using skin as a model organ
Hudson, L., Bowman, A., Rashdan, E., & Birch-Machin, M. A. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.04.021 · Cited by 25 · see citing works
“Even if this vicious cycle is not occurring, any damage to mtDNA or mitochondria directly by UVR could still result in an increase in photoageing, as mitochondria are thought to play a prominent role in the ageing process [19].”
BackgroundInfluential
- Authors
- Kandola, K., Bowman, A., & Birch‐Machin, M. A.
- Affiliations
- Newcastle University (GB)
- Dermatology Medical School Newcastle University Newcastle upon Tyne NE24HH U.K.
- Venue
- International Journal of Cosmetic Science
- Publisher
- Wiley
- Published
- 2015-11-17
- Volume
- 37
- Issue
- S2
- Pages
- 1-8
- ISSN
- 0142-5463 (ISSN-L)
- 1468-2494
- OpenAlex
- W2176708443
- Cited by
- 103
- References
- 87
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 14 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 12 · 2018: 7 · 2017: 15 · 2016: 11
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cosmetic Science (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- oxidative stress, reactive oxygen species, free radicals, antioxidants, lipid peroxidation, mitochondrial ROS generation, superoxide, inflammation, cytotoxicity, aging, skin aesthetics, neurological disorders, cardiovascular disease, skin diseases, anti-aging interventions
- MeSH terms
- Aging, Esthetics, Health Status, Humans, Life Style, Mitochondria, Reactive Oxygen Species, Oxidative Stress
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