The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.
Aurora‐A Kinase: A Potent Oncogene and Target for Cancer Therapy
Abstract
The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis, whereas Aurora‐C executes unique roles in meiosis. Overexpression or gene amplification of Aurora kinases has been reported in a broad range of human malignancies, pointing to their role as potent oncogenes in tumorigenesis. Aurora kinases therefore represent promising targets for anticancer therapeutics. A number of Aurora kinase inhibitors (AKIs) have been generated; some of which are currently undergoing clinical evaluation. Recent studies have unveiled novel unexpected functions of Aurora kinases during cancer development and the mechanisms underlying the anticancer actions of AKIs. In this review, we discuss the most recent advances in Aurora‐A kinase research and targeted cancer therapy, focusing on the oncogenic roles and signaling pathways of Aurora‐A kinases in promoting tumorigenesis, the recent preclinical and clinical AKI data, and potential alternative routes for Aurora‐A kinase inhibition.
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Cites
2 retracted
BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition
Ouchi, M., Fujiuchi, N., Sasai, K., Katayama, H., Minamishima, Y. A., Ongusaha, P. P., Deng, C., Sen, S., Lee, S. W., & Ouchi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311780200 · Cited by 199
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RetractedMyeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Zhou, H., Kuang, J., Zhong, L., Kuo, W.-L., Gray, J., Sahin, A., Brinkley, B., & Sen, S. (1998) · Nature Genetics · doi:10.1038/2496 · Cited by 1,276
The cellular geography of Aurora kinases
Carmena, M., & Earnshaw, W. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1245 · Cited by 1,139
Nuclear localization of EGF receptor and its potential new role as a transcription factor
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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
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Harrington, E. A., Bebbington, D., Moore, J., Rasmussen, R. K., Ajose-Adeogun, A. O., Nakayama, T., Graham, J. A., Demur, C., Hercend, T., Diu-Hercend, A., et al. (2004) · Nature Medicine · doi:10.1038/nm1003 · Cited by 965
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
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Cited by
Aurora kinases: novel therapy targets in cancers
Tang, A., Gao, K., Chu, L., Zhang, R., Yang, J., & Zheng, J. (2017) · Oncotarget · doi:10.18632/oncotarget.14893 · Cited by 382
Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium
Konkankit, C. C., Marker, S. C., Knopf, K. M., & Wilson, J. J. (2018) · Dalton Transactions · doi:10.1039/c8dt01858h · Cited by 284
Metadata
- Authors
- Yan, M., Wang, C., He, B., Yang, M., Tong, M., Long, Z., Liu, B., Peng, F., Xu, L., Zhang, Y., Liang, D., Lei, H., Subrata, S., Kelley, K. W., Lam, E. W. ‐., Jin, B., & Liu, Q.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2016-07-13
- Volume
- 36
- Issue
- 6
- Pages
- 1036-1079
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2503725456
- Cited by
- 293
- References
- 210
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yan, M., Wang, C., He, B., Yang, M., Tong, M., Long, Z., Liu, B., Peng, F., Xu, L., Zhang, Y., Liang, D., Lei, H., Subrata, S., Kelley, K. W., Lam, E. W. ‐., Jin, B., & Liu, Q. (2016). Aurora‐A Kinase: A Potent Oncogene and Target for Cancer Therapy. Medicinal Research Reviews. https://doi.org/10.1002/med.21399
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