The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy
Abstract
Gene‐based therapy is one of essential therapeutic strategies for precision medicine through targeting specific genes in specific cells of target tissues. However, there still exist many problems that need to be solved, such as safety, stability, selectivity, delivery, as well as immunity. Currently, the key challenges of gene‐based therapy for clinical potential applications are the safe and effective nucleic acid drugs as well as their safe and efficient gene delivery systems. In this review, we first focus on current nucleic acid drugs and their formulation in clinical trials and on the market, including antisense oligonucleotide, siRNA, aptamer, and plasmid nucleic acid drugs. Subsequently, we summarize different chemical modifications of nucleic acid drugs as well as their delivery systems for gene‐based therapeutics in vivo based on nucleic acid chemistry and nanotechnology methods.
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Cites
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Cited by
The growth of siRNA-based therapeutics: updated clinical studies
Zhang, M. M., Bahal, R., Rasmussen, T. P., Manautou, J. E., & Zhong, X.-B. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114432 · Cited by 497
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Recent progress in non-native nucleic acid modifications
McKenzie, L. K., El-Khoury, R., Thorpe, J. D., Damha, M. J., & Hollenstein, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01430c · Cited by 300
Hyaluronic acid and albumin based nanoparticles for drug delivery
Lei, C., Liu, X.-R., Chen, Q.-B., Li, Y., Zhou, J.-L., Zhou, L.-Y., & Zou, T. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.033 · Cited by 266
Pandey, M., Ojha, D., Bansal, S., Rode, A. B., & Chawla, G. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101003 · Cited by 23
Metadata
- Authors
- Chen, C., Yang, Z., & Tang, X.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2018-01-05
- Volume
- 38
- Issue
- 3
- Pages
- 829-869
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2783757852
- Cited by
- 158
- References
- 14
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
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