Leptin Resistance and Obesity

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725 · see citing works

Obesity and the regulation of energy balance

Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214 · see citing works

Anatomy and regulation of the central melanocortin system

Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583 · see citing works

Leptin-regulated endocannabinoids are involved in maintaining food intake

Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559 · see citing works

Identification of targets of leptin action in rat hypothalamus.

Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works

Leptin enters the brain by a saturable system independent of insulin

Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222 · see citing works

The Need to Feed

Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120 · see citing works

Receptor-mediated regional sympathetic nerve activation by leptin.

Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979 · see citing works

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935 · see citing works

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924 · see citing works

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879 · see citing works

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works

Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol

Kirkham, T. C., Williams, C. M., Fezza, F., & Marzo, V. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704767 · Cited by 788 · see citing works

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works

Health consequences of obesity in the elderly: a review of four unresolved questions

Zamboni, M. M., Mazzali, G., Zoico, E., Harris, T. B., Meigs, J. B., Francesco, V. D., Fantin, F., Bissoli, L., & Bosello, O. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803005 · Cited by 649 · see citing works

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight

Rosenbaum, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25977 · Cited by 575 · see citing works

Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice

Lin, S., Thomas, T. C., Storlien, L., & Huang, X. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801209 · Cited by 570 · see citing works

Molecular and anatomical determinants of central leptin resistance

Münzberg, H., & Myers, M. G. (2005) · Nature Neuroscience · doi:10.1038/nn1454 · Cited by 550 · see citing works

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

Mizuno, T. M., Kleopoulos, S. P., Bergen, H., Roberts, J. L., Priest, C. A., & Mobbs, C. V. (1998) · Diabetes · doi:10.2337/diab.47.2.294 · Cited by 521 · see citing works

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490 · see citing works

The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.004 · Cited by 457 · see citing works

Appetite control

Wynne, K., Stanley, S., McGowan, B. M., & Bloom, S. R. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05866 · Cited by 452 · see citing works

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D. (2004) · Nature Neuroscience · doi:10.1038/nn1226 · Cited by 435 · see citing works

SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats

Cohen, C., Perrault, G., Voltz, C., Steinberg, R., & Soubrié, P. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200209000-00018 · Cited by 396 · see citing works

Leptin increases uncoupling protein expression and energy expenditure

Scarpace, P. J., Matheny, M. E., Pollock, B. H., & Tümer, N. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e226 · Cited by 390 · see citing works

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

de Luca, C., Kowalski, T. J., Zhang, Y., Elmquist, J. K., Lee, C., Kilimann, M. W., Ludwig, T. E., Liu, S.-M., & Chua, S. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24059 · Cited by 383 · see citing works

Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter

Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., Friedman, J. M., & Elmquist, J. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07143.2003 · Cited by 375 · see citing works

Leptin: Structure, Function and Biology

Zhang, F. P. Y., Chen, Y., Heiman, M. L., & DiMarchi, R. D. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71012-8 · Cited by 343 · see citing works

Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats

Cheer, J. F., Wassum, K. M., Heien, M. L. A. V., Phillips, P. E. M., & Wightman, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0529-04.2004 · Cited by 343 · see citing works

Epidemiologic aspects of overweight and obesity in the United States☆

FLEGAL, K. (2005) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2005.08.050 · Cited by 284 · see citing works

Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716)

Cohen, C., Perrault, G., Griebel, G., & Soubrié, P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300541 · Cited by 251 · see citing works

Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible

Banks, W. A., & Farrell, C. L. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00468.2002 · Cited by 241 · see citing works

The role of insulin receptor substrate 2 in hypothalamic and β cell function

Choudhury, A. I., Heffron, H., Smith, M. A., Al‐Qassab, H., Xu, A. W., Selman, C., Simmgen, M., Clements, M., Claret, M., MacColl, G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24445 · Cited by 241 · see citing works

Integration of Endocannabinoid and Leptin Signaling in an Appetite-Related Neural Circuit

Jo, Y., Chen, Y.-J. J., Chua, S. C., Talmage, D. A., & Role, L. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.021 · Cited by 233 · see citing works

Monitoring of stored and available fuel by the CNS: implications for obesity

Seeley, R. J., & Woods, S. C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1245 · Cited by 228 · see citing works

Rodent obesity models: An overview

Tschöp, M. H., & Heiman, M. L. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-17297 · Cited by 220 · see citing works

Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin1

Mizuno, T. M., Makimura, H., Silverstein, J. H., Roberts, J. L., Lopingco, T., & Mobbs, C. V. (1999) · Endocrinology · doi:10.1210/endo.140.10.6966 · Cited by 189 · see citing works

Induction of Uncoupling Protein Expression in Brown and White Adipose Tissue by Leptin**This work was supported by a research grant from the American Diabetes Association, USPHS Grant DK-53981, and a research grant from the USDA (NRICGP/USDA 9800699).

Commins, S. P., Watson, P. M., Padgett, M. A., Dudley, A. C., Argyropoulos, G. A., & Gettys, T. W. (1999) · Endocrinology · doi:10.1210/endo.140.1.6399 · Cited by 185 · see citing works

Respiration uncoupling and metabolism in the control of energy expenditure

Ricquier, D. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004408 · Cited by 175 · see citing works

Gonadotropin-Releasing Hormone Agonists in the Treatment of Prostate Cancer

Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J., & Candas, B. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0017 · Cited by 169 · see citing works

Norepinephrine Is Required for Leptin Effects on Gene Expression in Brown and White Adipose Tissue¹

Commins, S. P., Marsh, D. J., Thomas, S. A., Watson, P. M., Padgett, M. A., Palmiter, R., & Gettys, T. W. (1999) · Endocrinology · doi:10.1210/endo.140.10.7043 · Cited by 107 · see citing works

Evidence for an Interaction between CB1 Cannabinoid and Melanocortin MCR-4 Receptors in Regulating Food Intake

Verty, A. N. A., McFarlane, J. R., McGregor, I. S., & Mallet, P. E. (2004) · Endocrinology · doi:10.1210/en.2004-0059 · Cited by 100 · see citing works

Rimonabant: The first therapeutically relevant cannabinoid antagonist

Carai, M. A. M., Colombo, G., & Gessa, G. L. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.04.017 · Cited by 90 · see citing works

Differential Mechanisms and Development of Leptin Resistance in A/J Versus C57BL/6J Mice during Diet-Induced Obesity

Prpić, V., Watson, P. M., Frampton, I. C., Sabol, M. A., Jezek, G. E., & Gettys, T. W. (2003) · Endocrinology · doi:10.1210/en.2002-220835 · Cited by 82 · see citing works

Regulation of thermogenesis by the central melanocortin system

Fan, W., Voss-Andreae, A., Cao, W.-H., & Morrison, S. F. (2005) · Peptides · doi:10.1016/j.peptides.2004.11.033 · Cited by 77 · see citing works

Induction of Uncoupling Protein Expression in Brown and White Adipose Tissue by Leptin

Commins, S. P. (1999) · Endocrinology · doi:10.1210/en.140.1.292 · Cited by 50 · see citing works

Contribution of plasma homovanillic acid (HVA) to urine and cerebrospinal gluid HVA in the monkey and its pharmacokinetic disposition

Elchisak, M. A., Polinsky, R. J., Ebert, M. H., POWERS, K. J., & Kopin, I. J. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90200-x · Cited by 41 · see citing works

Untitled work

Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4

Obesity and Cardiovascular Disease

Lavie, C. J., Milani, R. V., & Ventura, H. O. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.068 · Cited by 2,326 · see citing works

The Emerging Role of Adipokines as Mediators of Cardiovascular Function: Physiologic and Clinical Perspectives

Gualillo, O., González-Juanatey, J. R., & Lago, F. (2007) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.09.005 · Cited by 193 · see citing works

Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet

Prior, R. L., Wu, X., Gu, L., Hager, T., Hager, A., Wilkes, S., & Howard, L. (2009) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.200900026 · Cited by 143 · see citing works

Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review

Bodnaruc, A. M., Prud’homme, D., Blanchet, R., & Giroux, I. (2016) · Nutrition &amp; Metabolism · doi:10.1186/s12986-016-0153-3 · Cited by 139 · see citing works

A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior

Burger, K. S., & Berner, L. A. (2014) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2014.04.025 · Cited by 110 · see citing works

Obesity Increases the Risk of Tendinopathy, Tendon Tear and Rupture, and Postoperative Complications: A Systematic Review of Clinical Studies

Macchi, M., Spezia, M., Elli, S., Schiaffini, G., & Chisari, E. (2020) · Clinical Orthopaedics &amp; Related Research · doi:10.1097/corr.0000000000001261 · Cited by 108 · see citing works

Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population

Romero-Corral, A., Sierra-Johnson, J., Lopez-Jimenez, F., Thomas, R. J., Singh, P., Hoffmann, M., Okcay, A., Korinek, J., Wolk, R., & Somers, V. K. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1218 · Cited by 77 · see citing works

The Treatment of Obesity and Its Co-Occurrence With Substance Use Disorders

VanBuskirk, K. A., & Potenza, M. N. (2010) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e3181ce38e7 · Cited by 48 · see citing works

The obesity treatment dilemma: Why dieting is both the answer and the problem? A mechanistic overview

Monnier, L., Schlienger, J.-L., Colette, C., & Bonnet, F. (2021) · Diabetes &amp; Metabolism · doi:10.1016/j.diabet.2020.09.002 · Cited by 47 · see citing works

Withaferin A protects against high-fat diet-induced obesity via attenuation of oxidative stress, inflammation, and insulin resistance

Abu Bakar, M. H., Azmi, M. N., Shariff, K. A., & Tan, J. S. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-2920-2 · Cited by 47 · see citing works

Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: implications for obesity-associated colon carcinogenesis

Song, N.-Y., Lee, Y.-H., Na, H.-K., Baek, J.-H., & Surh, Y.-J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.001 · Cited by 36 · see citing works

Short-term GLP-1 receptor agonist exenatide ameliorates intramyocellular lipid deposition without weight loss in ob/ob mice

Xu, F., Cao, H., Chen, Z., Gu, H., Guo, W., Lin, B., & Weng, J. (2020) · International Journal of Obesity · doi:10.1038/s41366-019-0513-y · Cited by 31 · see citing works

Sparse System Identification of Leptin Dynamics in Women With Obesity

Amin, M. R., Pednekar, D. D., Azgomi, H. F., van Wietmarschen, H., Aschbacher, K., & Faghih, R. T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.769951 · Cited by 14 · see citing works

흰쥐의 발정주기동안 난소내 Leptin 및 Leptin 수용체 발현의 주기적 변화에 관한 연구

김명신, 양현원, 권혁찬, et al. (2002) · 발생과 생식

흰쥐 난소내 Leption 및 Leption 수용체의 발현

김명신, 양현원, 권혁찬, et al. (1998) · 발생과 생식

Expression of Obesity Hormone Leptin in Human Colorectal Cancer

Jin-chun, Cong, C., Xianwei, et al. (2009) · Acta Scientiarum Naturalium Universitatis Sunyatseni

Application of the Doubly Labeled Water Technique for Studying Total Energy Expenditure in Young Children: A Review

Goran, M. I. (1994) · Pediatric Exercise Science · doi:10.1123/pes.6.1.11 · Cited by 25 · see citing works

Body size, spontaneous activity and thermogenesis effects on energy expenditure: an introduction to a topic on energy metabolism

Even, P. C. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00301 · Cited by 4 · see citing works