The DOI matches its Crossref record; 262 of the 264 references it cites were found in a registry or an index.
Toxicology and risk assessment of coumarin: Focus on human data
Abstract
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolerable daily intake (TDI) for the first time, and a value of 0.1 mg/kg body weight was arrived at based on animal hepatotoxicity data. However, clinical data on hepatotoxicity from patients treated with coumarin as medicinal drug is also available. This data revealed a subgroup of the human population being more susceptible for the hepatotoxic effect than the animal species investigated. The cause of the high susceptibility is currently unknown; possible mechanisms are discussed. Using the human data, a TDI of 0.1 mg/kg body weight was derived, confirming that of the European Food Safety Authority. Nutritional exposure may be considerably, and is mainly due to use of cassia cinnamon, which is a popular spice especially, used for cookies and sweet dishes. To estimate exposure to coumarin during the Christmas season in Germany, a telephone survey was performed with more than 1000 randomly selected persons. Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI.
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“unlike Ceylon cinnamon (Cinnamomum zeylanicum or Cinnamomum verum), coming from Sri Lanka and Madagascar, which contains only traces of coumarin [19].”
In the citing paper
“For the cassia species however, coumarin levels are of concern [19].”
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Metadata
- Authors
- Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A.
- Affiliations
- German Federal Institute for Risk Assessment (BfR) (DE)
- Corresponding author
- Abraham, Klaus
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 54
- Issue
- 2
- Pages
- 228-239
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1972248486
- Cited by
- 292
- References
- 264
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 29 · 2021: 21 · 2020: 32 · 2019: 17 · 2018: 15 · 2017: 17 · 2016: 11 · 2015: 16 · 2014: 11 · 2013: 7 · 2012: 8
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- OpenAgrar (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Plant Toxicity and Pharmacological Properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- coumarins, hepatotoxicity, carcinogenicity, genotoxicity, tolerable daily intake, risk assessment, telephone surveys
- MeSH terms
- Animals, Biotransformation, Coumarins, Edema, Flavoring Agents, Humans, Liver Neoplasms, Lymphedema, Plants, Medicinal, Species Specificity, Venous Insufficiency, Risk Assessment, Toxicity Tests, Chemical and Drug Induced Liver Injury
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