Cited by 292Plant chemical constituents analysisPlant Toxicity and Pharmacological PropertiesCarcinogens and Genotoxicity Assessment

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Toxicology and risk assessment of coumarin: Focus on human data

Abraham, Klaus, Wöhrlin, Friederike, Lindtner, Oliver, Heinemeyer, Gerhard, Lampen, Alfonso·2010·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.200900281

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Abstract

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolerable daily intake (TDI) for the first time, and a value of 0.1 mg/kg body weight was arrived at based on animal hepatotoxicity data. However, clinical data on hepatotoxicity from patients treated with coumarin as medicinal drug is also available. This data revealed a subgroup of the human population being more susceptible for the hepatotoxic effect than the animal species investigated. The cause of the high susceptibility is currently unknown; possible mechanisms are discussed. Using the human data, a TDI of 0.1 mg/kg body weight was derived, confirming that of the European Food Safety Authority. Nutritional exposure may be considerably, and is mainly due to use of cassia cinnamon, which is a popular spice especially, used for cookies and sweet dishes. To estimate exposure to coumarin during the Christmas season in Germany, a telephone survey was performed with more than 1000 randomly selected persons. Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI.

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Authors: Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A.
Affiliations: German Federal Institute for Risk Assessment (BfR) (DE)
Corresponding author: Abraham, Klaus
ORCID: Abraham, Klaus
Lindtner, Oliver
Heinemeyer, Gerhard
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2010-02
Volume: 54
Issue: 2
Pages: 228-239
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.200900281
OpenAlex: W1972248486
Cited by: 292
References: 264
Citations by year: 2026: 22 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 29 · 2021: 21 · 2020: 32 · 2019: 17 · 2018: 15 · 2017: 17 · 2016: 11 · 2015: 16 · 2014: 11 · 2013: 7 · 2012: 8
FWCI: 0.63
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
OpenAgrar (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Plant Toxicity and Pharmacological Properties
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: coumarins, hepatotoxicity, carcinogenicity, genotoxicity, tolerable daily intake, risk assessment, telephone surveys
MeSH terms: Animals, Biotransformation, Coumarins, Edema, Flavoring Agents, Humans, Liver Neoplasms, Lymphedema, Plants, Medicinal, Species Specificity, Venous Insufficiency, Risk Assessment, Toxicity Tests, Chemical and Drug Induced Liver Injury

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Toxicology and risk assessment of coumarin: Focus on human data

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