Polyphenol Rich Olive Oils Improve Lipoprotein Particle Atherogenic Ratios and Subclasses Profile: A Randomized, Crossover, Controlled Trial
Open accessAbstract
SCOPE: Lipoprotein particle measures performed by nuclear magnetic resonance (NMR), and associated ratios, may be better markers for atherosclerosis risk than conventional lipid measures. The effect of two functional olive oils, one enriched with its polyphenols (FVOO, 500 ppm), and the other (FVOOT) with them (250 ppm) and those of thyme (250 ppm), versus a standard virgin olive oil (VOO), on lipoprotein particle atherogenic ratios and subclasses profiles was assessed. METHODS AND RESULTS: In a randomized, double-blind, crossover, controlled trial, 33 hypercholesterolemic individuals received 25 mL/day of VOO, FVOO, and FVOOT. Intervention periods were of 3 weeks separated by 2-week washout periods. Lipoprotein particle counts and subclasses were measured by NMR. Polyphenols from olive oil and thyme modified the lipoprotein subclasses profile and decreased the total LDL particle/total HDL particle (HDL-P), small HDL/large HDL, and HDL-cholesterol/HDL-P ratios, and decreased the lipoprotein insulin resistance index (LP-IR) (p < 0.05). CONCLUSION: Olive oil polyphenols, and those from thyme provided benefits on lipoprotein particle atherogenic ratios and subclasses profile distribution. Polyphenol-enriched olive oil is a way of increasing the olive oil healthy properties while consuming the same amount of fat, as well as a useful and complementary tool for the management of cardiovascular risk individuals.
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The study population was predominantly European and healthy adults, with two studies including type 2 diabetes mellitus and hypercholesterolemic subjects.
“The study population was predominantly European and healthy.”
From Olive Oil Polyphenols Improve HDL Cholesterol and Promote Maintenance of Lipid Metabolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023) · cites this paper as [35]
Section 2.2 (Study subjects; page unavailable) describes participants who were hypercholesterolemic but otherwise met normal clinical and laboratory criteria; diabetes was an exclusion. The paper does not establish that the population across studies was predominantly European and healthy, or that two studies included the specified patient groups. (LLM, conf=0.83)
Experimental — accuracy not yet measuredOnly 4 of the 10 selected studies performed the dietary intervention in a double-blind way.
“Only 4 of the 10 selected studies performed the dietary intervention in a double-blind way [31,33,35,40].”
Ten RCTs met the inclusion criteria and were included in the meta-analysis.
“After reviewing the full text of the remaining records, only 10 met the inclusion criteria and were included in the meta-analysis [31,32,33,34,35,36,37,38,39,40].”
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“Only 4 of the 10 selected studies performed the dietary intervention in a double-blind way [31,33,35,40].”
BackgroundSarapis, K., George, E. S., Marx, W., Mayr, H. L., Willcox, J., Powell, K. L., Folasire, O. S., Lohning, A. E., Prendergast, L. A., Itsiopoulos, C., et al. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114522003634 · Cited by 20 · see citing works
- Authors
- Fernández‐Castillejo, S., Valls, R., Castañer, O., Rubió, L., Catalán, Ú., Pedret, A., Macià, A., Sampson, M. L., Covas, M., Fitó, M., Motilva, M., Remaley, A. T., & Solà, R.
- Affiliations
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Hospital del Mar Research Institute (ES)
- Universitat de Lleida (ES)
- National Institutes of Health (US)
- Food Technology Department; Agrotecnio Center University of Lleida Lleida Spain
- Corresponding author
- Remaley, Alan T.
- Solà, Rosa
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2016-05-06
- Volume
- 60
- Issue
- 7
- Pages
- 1544-1554
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- PMC
- PMC4949304
- OpenAlex
- W2299421211
- Cited by
- 61
- References
- 47
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 13 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 1
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (acceptedVersion)
- UdL Open Repository (University of Lleida) (acceptedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion)
- Funders
- Ministry of Education and Science (AGL2009‐13517)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- olive oil polyphenols, thyme, HDL cholesterol, hypercholesterolemia, cardiovascular risk, atherosclerosis risk markers
- MeSH terms
- Olive Oil, Adult, Aged, Blood Glucose, Blood Pressure, Diet, Double-Blind Method, Female, Humans, Hypercholesterolemia, Insulin Resistance, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Patient Compliance, Risk Factors, Triglycerides, Exercise, Body Mass Index, Treatment Outcome, Sample Size, Cross-Over Studies, Atherosclerosis, Polyphenols
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