LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia
Abstract
Purpose Red yeast rice (RYR), sugar cane-derived policosanols (SCdP) and artichoke leaf extracts (ALEs) are currently incorporated alone or in combination into dietary supplements for their potential low-density-lipoprotein cholesterol (LDL-cholesterol)-lowering effects. Yet, there is no information supporting the efficacy of this association on the reduction in LDL-cholesterol. The main objective of this study was to investigate the effects of a new dietary supplement (DS) with RYR, SCdP and ALEs on LDL-cholesterol.Methods In a double-blind, randomized, parallel controlled study, 39 subjects from 21 to 55 years with moderate hypercholesterolemia without drug treatment were assigned to 2 groups and then consumed either a DS containing RYR, SCdP and ALEs or a placebo over a 16-week period. Plasma concentrations of lipids [LDL-cholesterol, total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-cholesterol), triacylglycerols (TG)] and plasma levels of vitamins C and E, total polyphenols and malondialdehyde were determined at baseline and after 4, 8, 12 and 16 weeks.Results LDL-cholesterol and TC were reduced by, respectively, 21.4 % (95 % CI, -13.3 to -24.9 %, p < 0.001) and 14.1 % (95 % CI, -10.1 to -18.0 %, p < 0.001) at week 16 in the DS group compared with baseline. Similar results were obtained at weeks 4, 8 and 12. TG decreased by 12.2 % after 16 weeks in the DS group (95 % CI: -24.4 to -0.1 %, p < 0.05). For the vitamin E/TC ratio, a difference was observed between groups at week 16 (p < 0.05). Other parameters were not modified.Conclusions Daily consumption of this new DS decreased LDL-cholesterol and TC and is therefore an interesting, convenient aid in managing mild to moderate hypercholesterolemia.
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In the same study, the combination decreased TG by 12.2% (95% CI: −24.4 to −0.1%, p < 0.05).
“In a double-blind, randomized, parallel controlled study on 39 subjects with moderate hypercholesterolemia, after 16 weeks of treatment, LDL-C was reduced by 21.4% (95% CI: − 13.3: − 24.9%, p < 0.001), while TG decreased by 12.2% (95% CI: − 24.4; − 0.1%, p < 0.05) [97].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [97]
In a double-blind, randomized, parallel controlled study of 39 subjects with moderate hypercholesterolemia, 16 weeks of treatment with a combination of RYR (166.67 mg, 0.4% monacolin K), sugar cane-derived policosanols (3.70 mg), and artichoke leaf extracts (200 mg, 5-6% chlorogenic acid) reduced LDL-C by 21.4% (95% CI: −13.3 to −24.9%, p < 0.001).
“In a double-blind, randomized, parallel controlled study on 39 subjects with moderate hypercholesterolemia, after 16 weeks of treatment, LDL-C was reduced by 21.4% (95% CI: − 13.3: − 24.9%, p < 0.001), while TG decreased by 12.2% (95% CI: − 24.4; − 0.1%, p < 0.05) [97].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [97]
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Self-citation
- Authors
- Ogier, N., Amiot, M.-J., Georgé, S., Maillot, M., Mallmann, C., Maraninchi, M., Morange, S., Lescuyer, J.-F., Peltier, S. L., & Cardinault, N.
- Affiliations
- Inserm (FR)
- Centre Technique de la Conservation des Produits Agricoles (FR)
- Venue
- European Journal of Nutrition
- Published
- 2012-04-24
- Volume
- 52
- Issue
- 2
- Pages
- 547-557
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- OpenAlex
- W2075076662
- Cited by
- 49
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- LDL cholesterol lowering, hypercholesterolemia, dietary supplements, red yeast rice, policosanol, artichoke leaf extract, total cholesterol, triglycerides, malondialdehyde, polyphenols, lipid profile
- MeSH terms
- Adult, Anticholesteremic Agents, Ascorbic Acid, Biological Products, Double-Blind Method, Fatty Alcohols, Female, Humans, Hypercholesterolemia, Cholesterol, HDL, Cholesterol, LDL, Male, Malondialdehyde, Middle Aged, Plant Extracts, Triglycerides, Vitamin E, Plant Leaves, Dietary Supplements, Cynara scolymus, Young Adult, Polyphenols
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