The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Scrotal heat stress effects on sperm viability, sperm DNA integrity, and the offspring sex ratio in mice
Open accessAbstract
Evidence exists to suggest detrimental effects of heat stress on male fertility. This study was designed to assess the effects of scrotal heat stress on mature and developing sperm in a mouse model. After receiving shock heat treatment (42°C for 30 min), mature spermatozoa were recovered from the epididymis hours (6) or Days (7, 14, 21, 28, 60) later, to determine the variables: number of spermatozoa, sperm viability, motility and progressive motility, sperm DNA integrity as established by the TUNEL method, embryo implantation rate, and sex ratio of the fetuses conceived using the heat‐exposed spermatozoa. Our results indicate that transient mild heat treatment does not affect in the same way the different types of male germ cells. Spermatocytes present within the testis at the time of heat stress resulted into a lower concentration of spermatozoa with reduced viability and low motility. Even though, DNA integrity of spermatozoa resulting from spermatocytes was also compromised by heat stress, the higher degree of DNA damage was found among spermatozoa resulting from spermatids present within the testis at the time of heat stress. At last, heat shock effect on spermatozoa present in the epididymis at the time of thermal stress resulted into a sex ratio distortion. These findings point to a higher sensitivity of spermatocytes to heat exposure and also suggest a different response of X and Y chromosome‐bearing spermatozoa to heat stress that warrants further investigation. Mol. Reprod. Dev. 75: 40–47, 2008. © 2007 Wiley‐Liss, Inc.
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Cites
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Viability Assessment of Mammalian Sperm Using SYBR-14 and Propidium Iodide1
Garner, D. L., & Johnson, L. A. (1995) · Biology of Reproduction · doi:10.1095/biolreprod53.2.276 · Cited by 717
Origin of DNA damage in ejaculated human spermatozoa
Sakkas, D. (1999) · Reviews of Reproduction · doi:10.1530/revreprod/4.1.31 · Cited by 526
Nature of DNA Damage in Ejaculated Human Spermatozoa and the Possible Involvement of Apoptosis1
Sakkas, D., Moffatt, O., Manicardi, G. C., Mariethoz, E., Tarozzi, N., & Bizzaro, D. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.4.1061 · Cited by 447
Fernández-Gonzalez, R., Moreira, P., Bilbao, A., Jiménez, A., Pérez-Crespo, M., Ramírez, M. A., De Fonseca, F. R., Pintado, B., & Gutiérrez-Adán, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308560101 · Cited by 370
Self-citationCorrelation of sperm motility with mitochondrial enzymatic activities
Ruiz-Pesini, E., Diez, C., Lapeña, A. C., Pérez-Martos, A., Montoya, J., Alvarez, E., Arenas, J., & López-Pérez, M. J. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.8.1616 · Cited by 293
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Impact of a mild scrotal heat stress on DNA integrity in murine spermatozoa
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Developmental capacity of damaged spermatozoa
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Cited by
Oxidative stress and male infertility—a clinical perspective
Tremellen, K. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn004 · Cited by 1,507
Effects of heat stress on mammalian reproduction
Hansen, P. J. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0131 · Cited by 743
Causes, effects and molecular mechanisms of testicular heat stress
Durairajanayagam, D., Agarwal, A., & Ong, C. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.09.018 · Cited by 431
The Impact of Climate Change on Fertility
Walsh, B. S., Parratt, S. R., Hoffmann, A. A., Atkinson, D., Snook, R. R., Bretman, A., & Price, T. A. R. (2019) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2018.12.002 · Cited by 320
Paul, C., Murray, A. A., Spears, N., & Saunders, P. T. K. (2008) · Reproduction · doi:10.1530/rep-08-0036 · Cited by 298
Metadata
- Authors
- Pérez‐Crespo, M., Pintado, B., & Gutiérrez‐Adán, A.
- Venue
- Molecular Reproduction and Development
- Publisher
- Wiley
- Published
- 2007-05
- Volume
- 75
- Issue
- 1
- Pages
- 40-47
- ISSN
- 1040-452X (ISSN-L)
- 1098-2795
- OpenAlex
- W2099315470
- Cited by
- 311
- References
- 21
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
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