The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
In vivo visualization of myelin water in brain by magnetic resonance
Abstract
We exploit the intrinsic difference in magnetic resonance spin‐spin relaxation time, T2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the brain. In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the de‐myelination process unavailable from conventional magnetic resonance images. In vivo myelin measurement has important applications in the clinical management of multiple sclerosis and other white matter diseases.
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Cites
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Self-citationAnisotropic diffusion in human white matter: demonstration with MR techniques in vivo.
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Cited by
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation
Novikov, D. S., Fieremans, E., Jespersen, S. N., & Kiselev, V. G. (2019) · NMR in Biomedicine · doi:10.1002/nbm.3998 · Cited by 581
White matter characterization with diffusional kurtosis imaging
Fieremans, E., Jensen, J. H., & Helpern, J. A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.006 · Cited by 561
Diffusion Tensor Imaging and Axonal Tracking in the Human Brainstem
Stieltjes, B., Kaufmann, W. E., van Zijl, P. C. M., Fredericksen, K., Pearlson, G. D., Solaiyappan, M., & Mori, S. (2001) · NeuroImage · doi:10.1006/nimg.2001.0861 · Cited by 492
Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology
Laule, C., Leung, E., Li, D. K., Traboulsee, A. L., Paty, D. W., MacKay, A. L., & Moore, G. R. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070928 · Cited by 489
Self-citation
Metadata
- Authors
- Mackay, A., Whittall, K., Adler, J., Li, D., Paty, D., & Graeb, D.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1994-06
- Volume
- 31
- Issue
- 6
- Pages
- 673-677
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2080737598
- Cited by
- 914
- References
- 16
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mackay, A., Whittall, K., Adler, J., Li, D., Paty, D., & Graeb, D. (1994). In vivo visualization of myelin water in brain by magnetic resonance. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910310614
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
