Cited by 492Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

Diffusion Tensor Imaging and Axonal Tracking in the Human Brainstem

Stieltjes, Bram, Kaufmann, Walter E., van Zijl, Peter C.M., Fredericksen, Kim, Pearlson, Godfrey D., Solaiyappan, Meiyappan, Mori, Susumu·2001·NeuroImage

Abstract

Diffusion tensor MRI was used to demonstrate in vivo anatomical mapping of brainstem axonal connections. It was possible to identify the corticospinal tract (CST), medial lemniscus, and the superior, medial, and inferior cerebellar peduncles. In addition, the cerebral peduncle could be subparcellated into component tracts, namely, the frontopontine tract, the CST, and the temporo-/parieto-/occipitopontine tract. Anatomical landmarks and tracking thresholds were established for each fiber and, using these standards, reproducibility of automated tracking as assessed by intra- and interrater reliability was found to be high (kappa > 0.82). Reconstructed fibers corresponded well to existing anatomical knowledge, validating the tracking. Information on the location of individual tracts was coregistered with quantitative MRI maps to automatically measure MRI parameters on a tract-by-tract basis. The results reveal that each tract has a unique spatial signature in terms of water relaxation and diffusion anisotropy.

Integrity signals

Registry

Crossref · 10.1006/nimg.2001.0861

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 31 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Stieltjes, B., Kaufmann, W. E., van Zijl, P. C. M., Fredericksen, K., Pearlson, G. D., Solaiyappan, M., & Mori, S.
Affiliations
  • Johns Hopkins University (US)
  • Kennedy Krieger Institute (US)
Venue
NeuroImage
Publisher
Elsevier BV
Published
2001-09
Volume
14
Issue
3
Pages
723-735
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2156715960
Cited by
492
References
31
Citations by year
2025: 3 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 14 · 2016: 13 · 2015: 23 · 2014: 22 · 2013: 26 · 2012: 18
FWCI
20.37
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r03ag016028-01)
  • National Institute on Aging (AG016028)
  • National Institute of Mental Health (MH 52886, R01MH052886)
  • National Institute of Biomedical Imaging and Bioengineering (P41EB015909)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37931, R03HD037931, HD24061, P30HD024061)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
brainstem, corticospinal tract, medial lemniscus, cerebellar peduncles, cerebral peduncle, tractography, diffusion anisotropy, water relaxation
MeSH terms
Adult, Axons, Brain Mapping, Brain Stem, Color, Differential Threshold, Female, Humans, Magnetic Resonance Imaging, Male, Anisotropy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review