Skeletal muscle function and hypertrophy are diminished in old age
Abstract
Muscle loss occurs during aging. To investigate whether the hypertrophic response is attenuated at old age, we used male Fischer 344 (26 months old; n = 5) and Fischer 344 x Brown Norway rats (6, 9, and 33 months old; n = 8, 10, and 6, respectively). Hypertrophy of the left plantaris muscle was induced by surgical denervation of its agonists. The right leg served as control. The mass and maximal tetanic force (P 0) of control muscles declined by ∼30% between 9 and 26 months (P < 0.05). Fatigue resistance during intermittent isometric contractions was reduced by ∼60% at 33 months. At 33 months, the attenuated hypertrophy was accompanied by a decrease rather than an increase in P 0. Yet, hypertrophy was accompanied by a 25% rise in fatigue resistance at all ages (P = 0.001). Thus, aging is associated with a decline in muscle mass and function. In addition, at advanced age, the hypertrophic response is reduced and a hypertrophic stimulus even aggravates the age‐associated muscle weakening. Muscle Nerve 27: 339–347, 2003
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The hypertrophic response of aging skeletal muscle may be blunted.
“observations that the hypertrophic response of aging skeletal muscle may be blunted [40–43]”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [40]
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Self-citationRegulation of p70S6k, GSK-3β, and calcineurin in rat striated muscle during aging
Kinnard, R. S., Mylabathula, D. B., Uddemarri, S., Rice, K., Wright, G. L., & Blough, E. (2005) · Biogerontology (Dordrecht) · doi:10.1007/s10522-005-7953-6 · Cited by 21 · see citing works
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Self-citationAge-related responses to a bout of mechanotherapy in skeletal muscle of rats
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Targeting Intramyocellular Lipids to Improve Aging Muscle Function
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Aging alters contractile properties and fiber morphology in pigeon skeletal muscle
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Self-citationNeto, W. K., Silva, W. D. A., Ciena, A. P., de Souza, R. R., Anaruma, C. A., & Gama, E. F. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00688 · Cited by 11 · see citing works
Activation of Lactate Receptor Positively Regulates Skeletal Muscle Mass in Mice
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Potential of autologous adipose‐derived stem cells to regenerate atrophied muscle in a rat model
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Interactions of Aging, Overload, and Creatine Supplementation in Rat Plantaris Muscle
Schuenke, M. D., Brooks, N. E., & Hikida, R. S. (2011) · Journal of Aging Research · doi:10.4061/2011/393416 · Cited by 9 · see citing works
Degens, H. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814593-7.00019-0 · Cited by 9 · see citing works
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Pharaoh, G. A., Ostrom, E. L., Stuppard, R., Campbell, M. D., Borghardt, J. M., Franti, M., Filareto, A., & Marcinek, D. J. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102770 · Cited by 8 · see citing works
PDGF-AB-based functional cardioprotection of the aging rat heart
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A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function
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Self-citationMuscle Wasting, Dysfunction, and Inflammaging
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Self-citationTransgene expression in hypertrophied and aged skeletal muscle in vivo by lentivirus delivery
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Self-citationDifferential regulation of apoptosis in slow and fast twitch muscles of aged female F344BN rats
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Myostatin deficiency blunts mechanical adaptation of soleus muscle to overload
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Self-citationSex-specific aging in bite force in a wild vertebrate
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Antioxidants and Polyphenols Mediate Mitochondrial Mediated Muscle Death Signaling in Sarcopenia
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Self-citation
- Authors
- Degens, H., & Alway, S. E.
- Affiliations
- Radboud University Nijmegen (NL)
- West Virginia University (US)
- Corresponding author
- Degens, Hans
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2003-02-20
- Volume
- 27
- Issue
- 3
- Pages
- 339-347
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2089950181
- Cited by
- 125
- References
- 30
- Citations by year
- 2026: 4 · 2025: 2 · 2023: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- e-space (Manchester Metropolitan University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- skeletal muscle aging, muscle atrophy, muscle hypertrophy, denervation-induced muscle atrophy, plantaris muscle, muscle fatigue resistance, muscle mass, age-related muscle weakness, F344 rats, Brown Norway rats
- MeSH terms
- Aging, Animals, Body Weight, Hypertrophy, Male, Muscle Contraction, Organ Size, Rats, Inbred BN, Rats, Inbred F344, Muscle, Skeletal, Muscle Fatigue, Muscle Weakness, Myosin Heavy Chains, Rats
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