Age-Related Deficit in Load-Induced Skeletal Muscle Growth

Hwee, D. T.; Bodine, S. C.

doi:10.1093/gerona/glp026

Cited by 74Muscle Physiology and DisordersSpaceflight effects on biologyNutrition and Health in Aging

Age-Related Deficit in Load-Induced Skeletal Muscle Growth

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Hwee, D. T., Bodine, S. C.·2009·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/glp026PMC PMC6587686

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Abstract

The growth response of ankle flexor and extensor muscles to two models of increased loading, functional overload (FO) and hind-limb reloading following hind-limb suspension, was measured by wet weight in Fisher 344-Brown Norway rats at ages ranging from 6 to 30 months. In response to FO, there was a 40% decrease in absolute growth of the plantaris beginning in middle age. Interestingly, the growth response to FO of 30-month old rats maintained on a 40% calorie-restricted diet improved by more than twofold relative to 30-month old rats on a normal chow diet. Recovery of muscle mass upon reloading following disuse was significantly impaired (reduced 7-16%) in predominantly fast, but not slow, muscles of 30-month relative to 9-month old rats. Initial investigation of the Akt signaling pathway following FO suggests a reduction or delay in activation of Akt and its downstream targets in response to increased loading in old rats.

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The hypertrophic response of aging skeletal muscle may be blunted.
“observations that the hypertrophic response of aging skeletal muscle may be blunted [40–43]”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [43]

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Authors: Hwee, D. T., & Bodine, S. C.
Affiliations: University of California, Davis (US)
ORCID: Hwee, D. T.
Bodine, S. C.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2009-04-07
Volume: 64A
Issue: 6
Pages: 618-628
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/glp026
PMC: PMC6587686
OpenAlex: W2116839423
Cited by: 74
References: 49
Citations by year: 2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 5
FWCI: 3.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Directorate for Biological Sciences
University of California, Davis
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075801)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords: skeletal muscle hypertrophy, functional overload, hindlimb unloading, disuse atrophy, plantaris muscle, caloric restriction, fast-twitch muscle, Akt signaling, aging, rats
MeSH terms: Adaptation, Physiological, Age Factors, Aging, Animals, Hindlimb, Male, Muscle Proteins, Rats, Inbred F344, Signal Transduction, Weight-Bearing, Muscle, Skeletal, Hindlimb Suspension, Models, Animal, Muscle Development, Caloric Restriction, Proto-Oncogene Proteins c-akt, Rats

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Age-Related Deficit in Load-Induced Skeletal Muscle Growth

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