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Cited by 129

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

A randomized trial of coenzyme Q 10 in mitochondrial disorders

Glover, Elisa I., Martin, Joan, Maher, Amy, Thornhill, Rebecca E., Moran, Gerald R., Tarnopolsky, Mark A.·2010·Muscle & Nerve
DOI 10.1002/mus.21758
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Abstract

Case reports and open‐label studies suggest that coenzyme Q 10 (CoQ 10 ) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ 10 for 60 days in a randomized, double‐blind, cross‐over trial. Blood lactate, urinary markers of oxidative stress, body composition, activities of daily living, quality of life, forearm handgrip strength and oxygen desaturation, cycle exercise cardiorespiratory variables, and brain metabolites were measured. CoQ 10 treatment attenuated the rise in lactate after cycle ergometry, increased (∽1.93 ml) V O 2 /kg lean mass after 5 minutes of cycling ( P < 0.005), and decreased gray matter choline‐containing compounds ( P < 0.05). Sixty days of moderate‐ to high‐dose CoQ 10 treatment had minor effects on cycle exercise aerobic capacity and post‐exercise lactate but did not affect other clinically relevant variables such as strength or resting lactate. Muscle Nerve, 2010

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Metadata

Authors
Glover, E. I., Martin, J., Maher, A., Thornhill, R. E., Moran, G. R., & Tarnopolsky, M. A.
Venue
Muscle & Nerve
Publisher
Wiley
Published
2010-09-30
Volume
42
Issue
5
Pages
739-748
ISSN
  • 0148-639X
  • 1097-4598
DOI
10.1002/mus.21758
Cited by
129
References
8
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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