Cited by 326Coenzyme Q10 studies and effectsParkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

Shults, Clifford W., Haas, Richard H., Passov, David, Beal, M. Flint·1997·Annals of Neurology

Abstract

The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q 10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q 10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age‐ and sex‐matched control subjects and that the levels of coenzyme Q 10 and the activities of complex I and complex II/III were significantly correlated.

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Crossref · 10.1002/ana.410420221

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  • Oral administration of CoQ10 in PD patients was well tolerated and resulted in significant, dose-dependent increases in plasma CoQ10 levels.

    “In this study, oral administration of CoQ10 in PD patients was well tolerated and resulted in significant, dose-dependent increases in plasma CoQ10 levels.”

    From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [159]

  • CoQ10 levels are significantly reduced in mitochondria isolated from platelets of PD patients, directly correlated with a decrease in complex-I activity.

    “We found a significant reduction in CoQ10 levels in mitochondria isolated from platelets of PD patients, that directly correlated with a decrease in complex-I activity159.”

    From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [159]

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Authors
Shults, C. W., Haas, R. H., Passov, D., & Beal, M. F.
Affiliations
  • United States Department of Veterans Affairs (US)
  • University of California San Diego (US)
  • Massachusetts General Hospital (US)
Corresponding author
Shults, Clifford W.
Venue
Annals of Neurology
Publisher
Wiley
Published
1997-08
Volume
42
Issue
2
Pages
261-264
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2084464741
Cited by
326
References
15
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 12 · 2021: 14 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 16 · 2013: 14 · 2012: 11
FWCI
2.00
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns032365-03, 5r01ns029504-03)
  • U.S. Public Health Service (P01 12992)
  • National Institute of Neurological Disorders and Stroke (R01 NS32365, R01 NS29504)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
coenzyme Q10, Parkinson's disease, mitochondrial complex I, platelet mitochondria, mitochondrial electron transport chain, mitochondrial dysfunction
MeSH terms
Blood Platelets, Coenzymes, Female, Humans, Male, Mitochondria, Multienzyme Complexes, Oxidoreductases, Parkinson Disease, Reference Values, Succinate Dehydrogenase, Electron Transport Complex III, Ubiquinone, NAD(P)H Dehydrogenase (Quinone), Electron Transport Complex II

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