Cited by 582Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

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Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections

Lexell, Jan, Henriksson‐Larsén, Karin, Winblad, Bengt, Sjöström, Michael·1983·Muscle & Nerve

DOI 10.1002/mus.880060809

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Abstract

The effects of aging on the total number and size of fibers, and the proportion and distribution of type 1 (slow twitch) and type 2 (fast twitch) fibers were studied in cross sections (15 μ thick) of autopsied whole m. vastus lateralis from two age groups. Each group consisted of six, previously physically healthy males (mean age 72 ± 1 years and 30 ± 6 years, respectively). The size of the muscles of the older individuals was 18% smaller ( P < 0.01) and the total number of fibers was 25% lower ( P < 0.01) than those of the young individuals (mean number 364,000 ± 50,000 vs 478,000 ± 56,000). There was, however, no significant difference in the mean fiber size (indirectly determined) orthe proportion of the two fiber types, though a preferential reduction in type 2 fiber number in the aged individuals was seen. The relative occurrence of the fiber types at various depths in the aged muscles was found to be more even than in muscles from the young individuals. The results suggest that the aging atrophy in m. vastus lateralis , at least up to the age of 70, is primarily the result of a loss of fibers.

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Authors: Lexell, J., Henriksson‐Larsén, K., Winblad, B., & Sjöström, M.
Affiliations: Umeå University (SE)
Corresponding author: Lexell, Jan
ORCID: Lexell, Jan
Winblad, Bengt
Venue: Muscle & Nerve
Publisher: Wiley
Published: 1983-10
Volume: 6
Issue: 8
Pages: 588-595
ISSN: 0148-639X (ISSN-L)
1097-4598
DOI: 10.1002/mus.880060809
OpenAlex: W2028656620
Cited by: 582
References: 23
Citations by year: 2026: 11 · 2025: 9 · 2024: 22 · 2023: 13 · 2022: 25 · 2021: 34 · 2020: 15 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 19 · 2015: 23 · 2014: 19 · 2013: 16 · 2012: 22
FWCI: 2.54
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7683 d)
Locations: Muscle & Nerve (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: skeletal muscle aging, fiber type distribution, vastus lateralis, muscle atrophy, fiber number, fiber diameter, muscle cross-section, age-related muscle loss
MeSH terms: Adult, Aged, Aging, Arteriosclerosis, Cell Count, Humans, Ischemia, Male, Muscles, Nerve Degeneration

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Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections

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