Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease
Open accessAbstract
Substantial evidence from epidemiological, pathological, and clinical reports suggests that vascular factors are critical in the pathogenesis of Alzheimer's disease (AD), and changes in blood flow are currently the most reliable indicators of the disease. We previously reported that older APP23 transgenic (tg) mice have significant blood flow alterations correlated with structural modifications of blood vessels. For the present study, our objective was to analyze the age-dependent morphological and architectural changes of the cerebral vasculature of APP23 tg mice. To visualize the 3D arrangement of the entire brain vasculature, we used vascular corrosion casts. Already at young ages, when typically parenchymal amyloid plaques are not yet present, APP23 tg mice had significant alterations, particularly of the microvasculature, often accompanied by small deposits attached to the vessels. In older animals, vasculature abruptly ended at amyloid plaques, resulting in holes. Often, small deposits were sitting near or at the end of truncated vessels. Between such holes, the surrounding vascular array appeared more dense and showed features typical for angiogenesis. We propose that small amyloid aggregates associated with the microvasculature lead to morphological and architectural alterations of the vasculature, resulting in altered local blood flow. The characteristic early onset of vascular alterations suggests that imaging blood flow and/or vasculature architecture could be used as a tool for early diagnosis of the disease and to monitor therapies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vasculopathy in murine models of amyloidosis has structural and functional consequences, including reduced cortical blood flow early in life and damaged capillary systems.
“A number of structural and functional consequences of vasculopathy have been reported in murine models of amyloidosis, such as reduced cortical blood flow already early in life (He ´bert et al., 2013), as well as damaged capillary systems (Meyer et al., 2008).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Meyer et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213 · see citing works
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590 · see citing works
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works
Self-citationIs Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
de la Torre, J. C. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00683-0 · Cited by 834 · see citing works
Roher, A. E., Lowenson, J. D., Clarke, S., Woods, A. S., Cotter, R. J., Gowing, E., & Ball, M. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10836 · Cited by 740 · see citing works
Brain Infarction and the Clinical Expression of Alzheimer Disease-Reply
Snowdon, D. A. (1997) · JAMA · doi:10.1001/jama.1997.03550020046024 · Cited by 683 · see citing works
Marti, H. J. H., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., & Risau, W. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64964-4 · Cited by 680 · see citing works
Calhoun, M. E., Burgermeister, P., Phinney, A. L., Stalder, M., Tolnay, M., Wiederhold, K.-H., Abramowski, D., Sturchler-Pierrat, C., Sommer, B., Staufenbiel, M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14088 · Cited by 410 · see citing works
Self-citationSOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
Iadecola, C., Zhang, F., Niwa, K., Eckman, C., Turner, S. K., Fischer, E., Younkin, S., Borchelt, D. R., Hsiao, K. K., & Carlson, G. A. (1999) · Nature Neuroscience · doi:10.1038/5715 · Cited by 399 · see citing works
Krucker, T., Siggins, G. R., & Halpain, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100139797 · Cited by 374 · see citing works
Self-citationCan disturbed brain microcirculation cause Alzheimer’s disease?
de la Torre, J. C., & Mussivan, T. (1993) · Neurological Research · doi:10.1080/01616412.1993.11740127 · Cited by 357 · see citing works
Brain Infarction and the Clinical Expression of Alzheimer Disease
Román, G. C. (1997) · JAMA · doi:10.1001/jama.1997.03550020045023 · Cited by 350 · see citing works
Clearing amyloid through the blood-brain barrier
Zlokovic, B. V. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02385.x · Cited by 336 · see citing works
Age‐dependent cognitive decline in the APP23 model precedes amyloid deposition
Dam, D. V., D’Hooge, R., Staufenbiel, M., Ginneken, C. J. V., Meir, F. V., & Deyn, P. P. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02444.x · Cited by 297 · see citing works
Self-citationSpontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy
Winkler, D. T., Bondolfi, L., Herzig, M. C., Jann, L., Calhoun, M. E., Wiederhold, K., Tolnay, M., Staufenbiel, M., & Jucker, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01619.2001 · Cited by 287 · see citing works
Self-citationNiwa, K., Kazama, K., Younkin, L., Younkin, S. G., Carlson, G. A., & Iadecola, C. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00022.2002 · Cited by 286 · see citing works
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
Wu, Z., Guo, H., Chow, N., Sallstrom, J., Bell, R. D., Deane, R., Brooks, A. I., Kanagala, S., Rubio, A., Sagare, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1287 · Cited by 280 · see citing works
Kovács, Z., Ikezaki, K., Samoto, K., Inamura, T., & Fukui, M. (1996) · Stroke · doi:10.1161/01.str.27.10.1865 · Cited by 277 · see citing works
Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders
Carmeliet, P., & Storkebaum, E. (2002) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2001.0290 · Cited by 249 · see citing works
Kuo, Y., Kokjohn, T. A., Beach, T. G., Sue, L. I., Brune, D. C., Lopez, J. C., Kalback, W. M., Abramowski, D., Sturchler, C., Staufenbiel, M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007859200 · Cited by 245 · see citing works
Self-citationAβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
Niwa, K., Younkin, L. H., Ebeling, C., Turner, S. K., Westaway, D. A., Younkin, S. G., Ashe, K. H., Carlson, G. A., & Iadecola, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9735 · Cited by 244 · see citing works
Shapira, I. L. (2008) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2008.0118 · Cited by 233 · see citing works
Molecular imaging of amyloid β peptides in mouse brain sections using mass spectrometry
Stoeckli, M., Staab, D., Staufenbiel, M., Wiederhold, K., & Signor, L. (2002) · Analytical Biochemistry · doi:10.1016/s0003-2697(02)00386-x · Cited by 225 · see citing works
Self-citationLametschwandtner, A., Lametschwandtner, U., & Weiger, T. M. (1990) · PubMed · Cited by 223 · see citing works
Yang, S., Bae, D., Kang, H. J., Gwag, B. J., Gho, Y. S., & Chae, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00111-8 · Cited by 170 · see citing works
Hierarchical microimaging for multiscale analysis of large vascular networks
Heinzer, S., Krucker, T., Stampanoni, M., Abela, R., Meyer, E. P., Schuler, A., Schneider, P., & Müller, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.043 · Cited by 170 · see citing works
Self-citationPathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model
Sturchler, C., & Staufenbiel, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06915.x · Cited by 168 · see citing works
Self-citationTong, X., Nicolakakis, N., Kocharyan, A., & Hamel, É. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4031-05.2005 · Cited by 153 · see citing works
Beckmann, N., Schuler, A., Mueggler, T., Meyer, E. P., Wiederhold, K., Staufenbiel, M., & Krucker, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08453.2003 · Cited by 148 · see citing works
Self-citationInhibition of Angiogenesis by Aβ Peptides
Paris, D., Townsend, K., Quadros, A., Humphrey, J., Sun, J., Brem, S., Wotoczek-Obadia, M., DelleDonne, A., Patel, N., Obregon, D. F., et al. (2004) · Angiogenesis · doi:10.1023/b:agen.0000037335.17717.bf · Cited by 148 · see citing works
Atherosclerosis of Cerebral Arteries in Alzheimer Disease
Roher, A. E., Esh, C. L., Rahman, A., Kokjohn, T. A., & Beach, T. G. (2004) · Stroke · doi:10.1161/01.str.0000143317.70478.b3 · Cited by 146 · see citing works
The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease.
Kawai, M., Kalaria, R. N., Harik, S. I., & Perry, G. L. (1990) · PubMed Central · Cited by 141 · see citing works
Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease
Prohovnik, I., Perl, D. P., Davis, K. L., Libow, L. S., Lesser, G. T., & Haroutunian, V. H. (2006) · Neurology · doi:10.1212/01.wnl.0000191298.68045.50 · Cited by 129 · see citing works
Krucker, T., Lang, A., & Meyer, E. P. (2006) · Microscopy Research and Technique · doi:10.1002/jemt.20263 · Cited by 129 · see citing works
Self-citationAlzheimer's Disease: A Description of the Structural Lesions
Probst, A., Langui, D., & ULRICH, J. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00666.x · Cited by 114 · see citing works
Compromised Hemodynamic Response in Amyloid Precursor Protein Transgenic Mice
Mueggler, T., Sturchler, C., Kindler, D., Rausch, M., Staufenbiel, M., & Rudin, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07218.2002 · Cited by 103 · see citing works
Self-citationPerfusion abnormalities in prodromal AD
Johnson, K. A., & Albert, M. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00137-8 · Cited by 101 · see citing works
Vascular abnormalities: the insidious pathogenesis of Alzheimer’s disease☆
Shi, J., Perry, G. L., Smith, M. A., & Friedland, R. P. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00119-6 · Cited by 86 · see citing works
Campbell, I. L. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00038-6 · Cited by 85 · see citing works
Vascular Basement Membrane Pathology and Alzheimer's Disease
Zarow, C., Barrón, E., Chui, H. C., & Perlmutter, L. S. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48467.x · Cited by 85 · see citing works
Ji, Y., Permanne, B., Sigurdsson, E. M., Holtzman, D. M., & Wısnıewskı, T. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3105 · Cited by 83 · see citing works
Heinzer, S., Kuhn, G. A., Krucker, T., Meyer, E., Ulmann‐Schuler, A., Stampanoni, M., Gassmann, M., Marti, H. H., Müller, R., & Vogel, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.054 · Cited by 69 · see citing works
Self-citationBateman, G. A., Levi, C. R., Schofield, P., Wang, Y., & Lovett, E. C. (2006) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.04.017 · Cited by 64 · see citing works
Krucker, T., Schuler, A., Meyer, E. P., Staufenbiel, M., & Beckmann, N. (2004) · Neurological Research · doi:10.1179/016164104225016281 · Cited by 56 · see citing works
Self-citationNeovasculature and blood-brain barrier in ischemic brain infarct
LIU, H. M. (1988) · Acta Neuropathologica · doi:10.1007/bf00687796 · Cited by 55 · see citing works
Arterial deformities in senile brains
HASSLER, O. (1967) · Acta Neuropathologica · doi:10.1007/bf00688824 · Cited by 55 · see citing works
Microvascular corrosion casting with analysis in the scanning electron microscope
Christoffersonm, R. H., & Nilsson, B. O. (1988) · Scanning · doi:10.1002/sca.4950100202 · Cited by 53 · see citing works
Kouznetsova, E., Klingner, M., Sorger, D., Sabri, O., Großmann, U., Steinbach, J., Scheunemann, M., & Schliebs, R. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.011 · Cited by 48 · see citing works
Weiger, T. M., Lametschwandtner, A., & Stockmayer, P. (1986) · PubMed · Cited by 46 · see citing works
Ultrastructure of capillary plaque-like degeneration in senile dementia
Miyakawa, T., Sumiyoshi, S., Murayama, E., & Deshimaru, M. (1974) · Acta Neuropathologica · doi:10.1007/bf00685258 · Cited by 45 · see citing works
Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze
Prut, L., Abramowski, D., Krucker, T., Levy, C. L., Roberts, A. J., Staufenbiel, M., & Wießner, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.017 · Cited by 38 · see citing works
Self-citationSchultheiß, C., Blechert, B., Gaertner, F. C., Drecoll, E., Mueller, J., Weber, G. F., Drzezga, A. E., & Essler, M. (2006) · Angiogenesis · doi:10.1007/s10456-006-9030-4 · Cited by 35 · see citing works
Burbach, G. J., Vlachos, A., Ghebremedhin, E., Turco, D. D., Coomaraswamy, J., Staufenbiel, M., Jucker, M., & Deller, T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.003 · Cited by 33 · see citing works
Self-citationCorrosion casts as a method for investigation of the insect tracheal system
Meyer, E. P. (1989) · Cell and Tissue Research · doi:10.1007/bf00224712 · Cited by 29 · see citing works
Self-citationCEREBRAL ARTERIAL DEFORMITIES IN RELATION TO SENILE DETERIORATION
Beskow, J., HASSLER, O., & Ottosson, J. (1971) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1971.tb02143.x · Cited by 23 · see citing works
Three Dimensional Microanatomy of Cells and Tissue Surfaces
(1981) · Elsevier eBooks · doi:10.1016/c2013-0-11818-1 · Cited by 15 · see citing works
Dementia with Cerebrovascular Disease
Wright, C. B., Vonsattel, J. P., Bell, K. L., & Honig, L. S. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.10.dn1 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The blood-brain barrier: an engineering perspective
Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662 · see citing works
Neuroinflammation in Alzheimer disease
Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638 · see citing works
Grammas, P. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-26 · Cited by 432 · see citing works
Santos, C. Y., Snyder, P. J., Wu, W., Zhang, M., Echeverria, A., & Alber, J. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.01.005 · Cited by 431 · see citing works
Vascular endothelial growth factor: a neurovascular target in neurological diseases
Lange, C. M., Storkebaum, E., de Almodóvar, C. R., Dewerchin, M. A., & Carmeliet, P. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.88 · Cited by 374 · see citing works
Zhan, X., Stamova, B. S., & Sharp, F. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 354 · see citing works
Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?
Stanimirovic, D. B., & Friedman, A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.25 · Cited by 352 · see citing works
Mechanisms of Vascular Aging, A Geroscience Perspective
Ungvari, Z. I., Tarantini, S., Sorond, F. A., Merkely, B. P., & Csiszár, A. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.061 · Cited by 329 · see citing works
β-Amyloid, Blood Vessels, and Brain Function
Smith, E. E., & Greenberg, S. M. (2009) · Stroke · doi:10.1161/strokeaha.108.536839 · Cited by 293 · see citing works
Govindpani, K., McNamara, L. G., Smith, N. R., Vinnakota, C., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050651 · Cited by 271 · see citing works
Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of Whole Mouse Brain
Xiong, B., Li, A., Lou, Y., Chen, S., Long, B., Peng, J., Yang, Z., Xu, T., Yang, X., Li, X., et al. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00128 · Cited by 247 · see citing works
Merlini, M., Meyer, E. P., Ulmann-Schuler, A., & Nitsch, R. M. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0834-y · Cited by 225 · see citing works
Self-citationMirochnic, S., Wolf, S. A., Staufenbiel, M., & Kempermann, G. (2009) · Hippocampus · doi:10.1002/hipo.20560 · Cited by 208 · see citing works
Self-citationMarino, A., Tricinci, O., Battaglini, M., Filippeschi, C., Mattoli, V., Sinibaldi, E., & Ciofani, G. (2017) · Small · doi:10.1002/smll.201702959 · Cited by 180 · see citing works
Dá Mesquita, S., Ferreira, A. C., Sousa, J. C., Correia-Neves, M., Sousa, N., & Marques, F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.014 · Cited by 166 · see citing works
X-ray computed tomography in life sciences
Rawson, S. D., Maksimcuka, J., Withers, P. J., & Cartmell, S. H. (2020) · BMC Biology · doi:10.1186/s12915-020-0753-2 · Cited by 165 · see citing works
Ramirez, J., Berezuk, C., McNeely, A. A., Gao, F., McLaurin, J., & Black, S. E. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0343-6 · Cited by 161 · see citing works
Plascencia‐Villa, G., Ponce, A., Collingwood, J. F., Arellano-Jiménez, M. J., Zhu, X., Rogers, J. T., Betancourt, I., José–Yacamán, M., & Perry, G. L. (2016) · Scientific Reports · doi:10.1038/srep24873 · Cited by 152 · see citing works
Ocular changes in TgF344-AD rat model of Alzheimer's disease
Tsai, Y., Lu, B., Ljubimov, A. V., Girman, S., Ross-Cisneros, F. N., Sadun, A. A., Svendsen, C. N., Cohen, R. M., & Wang, S. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-12888 · Cited by 153 · see citing works
Evidence of angiogenic vessels in Alzheimer’s disease
Desai, B. S., Schneider, J. A., Li, J.-L., Carvey, P. M., & Hendey, B. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0226-9 · Cited by 153 · see citing works
Lange‐Asschenfeldt, C., & Kojda, G. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.002 · Cited by 153 · see citing works
Peters, D. G., Connor, J. R., & Meadowcroft, M. D. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.007 · Cited by 145 · see citing works
Benchmarking in vitro tissue-engineered blood–brain barrier models
DeStefano, J. G., Jamieson, J. J., Linville, R. M., & Searson, P. C. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0117-2 · Cited by 142 · see citing works
Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease
Yezhuvath, U. S., Uh, J., Cheng, Y., Martin‐Cook, K., Weiner, M., Diaz-Arrastia, R. R., van Osch, M. J. P., & Lu, H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.005 · Cited by 131 · see citing works
Pathological changes within the cerebral vasculature in Alzheimer’s disease: New perspectives
Fisher, R. A., Miners, J. S., & Love, S. (2022) · Brain Pathology · doi:10.1111/bpa.13061 · Cited by 127 · see citing works
Iturria‐Medina, Y., Carbonell, F., Sotero, R. C., Chouinard-Decorte, F., & Evans, A. C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.058 · Cited by 126 · see citing works
Topology and Hemodynamics of the Cortical Cerebrovascular System
Hirsch, S., Reichold, J., Schneider, M., Székely, G. J., & Weber, B. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.39 · Cited by 130 · see citing works
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
Nehra, G., Bauer, B., & Hartz, A. M. S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108119 · Cited by 127 · see citing works
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease
Bracko, O., Hernández, J. C. C., Park, L., Nishimura, N., & Schaffer, C. B. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20982383 · Cited by 122 · see citing works
Hybrid FMT–CT imaging of amyloid-β plaques in a murine Alzheimer's disease model
Hyde, D. E., DEKLEINE, R., MacLaurin, S. A., Miller, E. L., BROOKS, D., Krucker, T., & Ntziachristos, V. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.038 · Cited by 123 · see citing works
Self-citationIncreased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease
Poisnel, G., Hérard, A., Tayara, N. E. T. E., Bourrin, E., Volk, A., Kober, F., Delatour, B., Delzescaux, T., Debeir, T., Rooney, T., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.026 · Cited by 120 · see citing works
Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations
Koizumi, K., Wang, G., & Park, L. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0256-9 · Cited by 117 · see citing works
<i>In Vivo</i> mouse imaging and spectroscopy in drug discovery
Beckmann, N., Kneuer, R., Gremlich, H., Karmouty‐Quintana, H., Blé, F., & Müller, M. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1153 · Cited by 118 · see citing works
Kavanagh, D., McGlasson, S. L., Jury, A., Williams, J., Scolding, N. J., Bellamy, C. O. C., Günther, C., Ritchie, D. L., Gale, D. P., Kanwar, Y. S., et al. (2016) · Blood · doi:10.1182/blood-2016-05-715987 · Cited by 116 · see citing works
Self-citationZhang, X., Yin, X., Zhang, J., Li, A., Gong, H., Luo, Q., Zhang, H., Gao, Z., & Jiang, H. (2019) · National Science Review · doi:10.1093/nsr/nwz124 · Cited by 116 · see citing works
Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease
Bonfili, L., Cecarini, V., Gogoi, O., Gong, C., Cuccioloni, M., Angeletti, M., Rossi, G., & Eleuteri, A. M. (2020) · FEBS Journal · doi:10.1111/febs.15571 · Cited by 118 · see citing works
Slevin, M., Matou, S., Zeinolabediny, Y., Corpas, R., Weston, R., Liu, D., Boras, E., Di Napoli, M., Petcu, E., Sarroca, S., et al. (2015) · Scientific Reports · doi:10.1038/srep13281 · Cited by 115 · see citing works
Tissue vascularization through 3D printing: Will technology bring us flow?
Paulsen, S. J., & Miller, J. S. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24254 · Cited by 114 · see citing works
Merlini, M., Wanner, D., & Nitsch, R. M. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1560-2 · Cited by 112 · see citing works
Ma, S., Kwon, H. J., Johng, H., Zang, K., & Huang, Z. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001469 · Cited by 109 · see citing works
Haft‐Javaherian, M., Fang, L., Muse, V., Schaffer, C. B., Nishimura, N., & Sabuncu, M. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213539 · Cited by 110 · see citing works
Cerebral autoregulation in Alzheimer's disease
Claassen, J. A. H. R., & Zhang, R. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.69 · Cited by 105 · see citing works
Biphasic Mechanisms of Neurovascular Unit Injury and Protection in CNS Diseases
Maki, T., Hayakawa, K., Pham, L. D., Xing, C., Lo, E. H., & Arai, K. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312030004 · Cited by 101 · see citing works
Patel, N. S., Mathura, V. S., Bachmeier, C. J., Beaulieu‐Abdelahad, D., Laporte, V., Weeks, O. I., MULLAN, M. J., & Paris, D. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06426.x · Cited by 99 · see citing works
Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler
Claassen, J. A. H. R., Diaz-Arrastia, R., Martin-Cook, K., Levine, B. D., & Zhang, R. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1079 · Cited by 95 · see citing works
Chuang, J., Lee, C.-W., Shih, Y., Yang, T., Yu, L., & Kuo, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033120 · Cited by 93 · see citing works
Neurovascular abnormalities in humans and mice with Huntington's disease
Lin, C.-Y., Hsu, Y.-H., Lin, M.-H., Yang, T.-H., Chen, H.-M., Chen, Y.-C., Hsiao, H.-Y., Chen, C.-C., Chern, Y., & Chang, C. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.08.019 · Cited by 98 · see citing works
Kelch, I. D., Bogle, G., Sands, G. B., Phillips, A. R. J., LeGrice, I. J., & Dunbar, P. R. (2015) · Scientific Reports · doi:10.1038/srep16534 · Cited by 92 · see citing works
Pansieri, J., Josserand, V., Lee, S.-J., Rongier, A., Imbert, D., Sallanon, M. M., Kövari, E., Dane, T. G., Vendrely, C., Chaix‐Pluchery, O., et al. (2019) · Nature Photonics · doi:10.1038/s41566-019-0422-6 · Cited by 88 · see citing works
Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease
Jefferies, W. A., Price, K. A., Biron, K. E., Fenninger, F., Pfeifer, C. G., & Dickstein, D. L. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt230 · Cited by 85 · see citing works
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer’s disease
Pimentel‐Coelho, P. M., & Rivest, S. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08126.x · Cited by 85 · see citing works
Hu, N., Smith, I. M., Walsh, D. M., & Rowan, M. J. (2008) · Brain · doi:10.1093/brain/awn174 · Cited by 84 · see citing works
Tseveleki, V., Rubio, R., Vamvakas, S. M., White, J., Taoufik, E., Petit, E., Quackenbush, J. F., & Probert, L. (2010) · Genomics · doi:10.1016/j.ygeno.2010.04.004 · Cited by 83 · see citing works
Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
Klohs, J., Rudin, M., Shimshek, D. R., & Beckmann, N. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00032 · Cited by 82 · see citing works
Microvascular Alterations in Alzheimer's Disease
Steinman, J., Sun, H., & Feng, Z. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.618986 · Cited by 82 · see citing works
Wälchli, T., Bisschop, J., Miettinen, A., Ulmann‐Schuler, A., Hintermüller, C., Meyer, E. P., Krucker, T., Waelchli, R., Monnier, P. P., Carmeliet, P., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00587-1 · Cited by 77 · see citing works
Self-citationAlzheimer’s and ABC transporters — new opportunities for diagnostics and treatment
Pahnke, J., Langer, O., & Krohn, M. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.001 · Cited by 81 · see citing works
Animal models reveal role for tau phosphorylation in human disease
Götz, J., Gladbach, A., Pennanen, L., van Eersel, J., Schild, A., David, D. C., & Ittner, L. M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.09.008 · Cited by 79 · see citing works
Branching patterns for arterioles and venules of the human cerebral cortex
Cassot, F., Lauwers, F., Lorthois, S., Puwanarajah, P., Cances-Lauwers, V., & Duvernoy, H. M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.12.007 · Cited by 79 · see citing works
Scaling Laws for Branching Vessels of Human Cerebral Cortex
Cassot, F., Lauwers, F., Lorthois, S., PRASANNA, P., & Duvernoy, H. M. (2009) · Microcirculation · doi:10.1080/10739680802662607 · Cited by 82 · see citing works
PET imaging with [18F]AV-45 in an APP/PS1-21 murine model of amyloid plaque deposition
Poisnel, G., Dhilly, M., Moustié, O., Delamare, J., Abbas, A., Guilloteau, D., & Barré, L. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.024 · Cited by 75 · see citing works
The next generation of endothelial differentiation: Tissue-specific ECs
Nguyen, J., Lin, Y.-Y., & Gerecht, S. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.05.002 · Cited by 79 · see citing works
Small Vessels Are a Big Problem in Neurodegeneration and Neuroprotection
Erdener, Ş. E., & Dalkara, T. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00889 · Cited by 76 · see citing works
Lin, A. J., Koike, M. A., Green, K. N., Kim, J. G., Mazhar, A., Rice, T. B., LaFerla, F. M., & Tromberg, B. J. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0269-6 · Cited by 75 · see citing works
A New Paradigm for the Treatment of Alzheimer's Disease: Targeting Vascular Activation
Grammas, P., Martinez, J. M., Sanchez, A. C., Yin, X., Riley, J., Gay, D., Desobry, K., Tripathy, D., Luo, J., Evola, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-2014-132057 · Cited by 73 · see citing works
Intravenous Delivery of Targeted Liposomes to Amyloid-β Pathology in APP/PSEN1 Transgenic Mice
Tanifum, E. A., Dasgupta, I., Srivastava, M., Bhavane, R. C., Sun, L., Berridge, J., Pourgarzham, H., Kamath, R., Espinosa, G., Cook, S. C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048515 · Cited by 73 · see citing works
Tissue metabolism driven arterial tree generation
Schneider, M., Reichold, J., Weber, B., Székely, G. J., & Hirsch, S. (2012) · Medical Image Analysis · doi:10.1016/j.media.2012.04.009 · Cited by 72 · see citing works
Katt, M. E., Mayo, L. N., Ellis, S., Mahairaki, V., Rothstein, J. D., Cheng, L., & Searson, P. C. (2019) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0139-4 · Cited by 69 · see citing works
Mann, A. P., Scodeller, P., Hussain, S., Braun, G. B., Mölder, T., Toome, K., Ambasudhan, R., Teesalu, T., Lipton, S. A., & Ruoslahti, E. I. (2017) · Nature Communications · doi:10.1038/s41467-017-01096-0 · Cited by 71 · see citing works
Grandjean, J., Schroeter, A., He, P., Tanadini, M., Keist, R., Krstic, D., Konietzko, U., Klohs, J., Nitsch, R. M., & Rudin, M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4762-13.2014 · Cited by 70 · see citing works
“, 2013), as well as damaged capillary systems (Meyer et al., 2008).”
BackgroundEndothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease
Storck, S. E., & Pietrzik, C. U. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2267-3 · Cited by 69 · see citing works
CD 4 T cells in immunity and immunotherapy of A lzheimer's disease
Monsonego, A., Nemirovsky, A., & Harpaz, I. (2013) · Immunology · doi:10.1111/imm.12103 · Cited by 71 · see citing works
Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology
Ries, M., Watts, H. R., Mota, B. C., Lopez, M. Y., Donat, C. K., Baxan, N., Pickering, J. A., Chau, T. W., Semmler, A., Gurung, B., et al. (2021) · Brain · doi:10.1093/brain/awab050 · Cited by 66 · see citing works
Cerebrovascular Disease, Amyloid Plaques, and Dementia
Liu, W., Wong, A., Law, A. C. K., & Mok, V. (2015) · Stroke · doi:10.1161/strokeaha.114.006571 · Cited by 67 · see citing works
Marottoli, F. M., Katsumata, Y., Koster, K. P., Thomas, R., Fardo, D. W., & Tai, L. M. (2017) · ASN NEURO · doi:10.1177/1759091417719201 · Cited by 68 · see citing works
Beckmann, N., Gérard, C., Abramowski, D., Cannet, C., & Staufenbiel, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4936-10.2011 · Cited by 65 · see citing works
Self-citationThe importance of BDNF and RAGE in diabetes-induced dementia
Kim, O. Y., & Song, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105083 · Cited by 65 · see citing works
Waste clearance shapes aging brain health
Jiang-Xie, L.-F., Drieu, A., & Kipnis, J. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.017 · Cited by 63 · see citing works
Morphometry of the hippocampal microvasculature in post‐stroke and age‐related dementias
Burke, M. J. C., Nelson, L., Slade, J. Y., Oakley, A. E., Khundakar, A. A., & Kalaria, R. N. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12085 · Cited by 63 · see citing works
Zerbi, V., Jansen, D., Wiesmann, M., Fang, X. T., Broersen, L. M., Veltien, A. A., Heerschap, A., & Kiliaan, A. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.038 · Cited by 62 · see citing works
Antiangiogenic Effect of Carnosic Acid and Carnosol, Neuroprotective Compounds in Rosemary Leaves
Kayashima, T., & Matsubara, K. (2012) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110584 · Cited by 59 · see citing works
Alzheimer’s-Related Peptide Amyloid-β Plays a Conserved Role in Angiogenesis
Cameron, D. J., Galvin, C. J., Alkam, T., Sidhu, H., Ellison, J., Luna, S., & Ethell, D. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039598 · Cited by 57 · see citing works
Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia?
Cederholm, T., & Palmblad, J. E. W. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328335c40b · Cited by 56 · see citing works
Kelly, P., Denver, P., Satchell, S. C., Ackermann, M., Konerding, M. A., & Mitchell, C. A. (2017) · Angiogenesis · doi:10.1007/s10456-017-9568-3 · Cited by 55 · see citing works
Bioprinting in Vascularization Strategies
Jafarkhani, M., Salehi, Z., Aidun, A., & Shokrgozar, M. A. (2018) · Iranian Biomedical Journal · doi:10.29252/ibj.23.1.9 · Cited by 54 · see citing works
Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice
Wiesmann, M., Zerbi, V., Jansen, D., Lütjohann, D., Veltien, A. A., Heerschap, A., & Kiliaan, A. J. (2017) · Theranostics · doi:10.7150/thno.18509 · Cited by 52 · see citing works
Luna, S., Cameron, D. J., & Ethell, D. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075052 · Cited by 51 · see citing works
Cerebrovascular phenotypes in mouse models of Alzheimer’s disease
Szu, J. I., & Obenaus, A. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x21992462 · Cited by 49 · see citing works
Nitric Oxide Inactivation Mechanisms in the Brain: Role in Bioenergetics and Neurodegeneration
Santos, R. M., Lourenço, C. F., Ledo, A., Barbosa, R. M., & Laranjinha, J. A. N. (2012) · International Journal of Cell Biology · doi:10.1155/2012/391914 · Cited by 51 · see citing works
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
Álvarez-Vergara, M. I., Rosales‐Nieves, A. E., March‐Díaz, R., Rodríguez-Periñán, G., Lara-Ureña, N., Luis, C. O. S., Sánchez-García, M. A., Martín‐Bórnez, M., Gómez‐Gálvez, P., Vicente‐Munuera, P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23337-z · Cited by 49 · see citing works
Paley, E. L. (2019) · International Journal of Tryptophan Research · doi:10.1177/1178646919834550 · Cited by 48 · see citing works
Hosono‐Fukao, T., Ohtake‐Niimi, S., Hoshino, H., Britschgi, M., Akatsu, H., Hossain, M. M., Nishitsuji, K., Kuppevelt, T. H. V., Kimata, K., Michikawa, M., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.01.015 · Cited by 48 · see citing works
VEGF receptor‐1 modulates amyloid β 1–42 oligomer‐induced senescence in brain endothelial cells
Angom, R. S., Wang, Y., Wang, E., Pal, K., Bhattacharya, S., Watzlawik, J. O., Rosenberry, T. L., Das, P., & Mukhopadhyay, D. (2018) · The FASEB Journal · doi:10.1096/fj.201802003r · Cited by 48 · see citing works
Kelly, P., McClean, P. L., Ackermann, M., Konerding, M. A., Hölscher, C., & Mitchell, C. A. (2014) · Microcirculation · doi:10.1111/micc.12186 · Cited by 47 · see citing works
Durrant, C. S., Ruscher, K., Sheppard, O., Coleman, M. P., & Özen, Í. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2288-4 · Cited by 46 · see citing works
Tortuosity and other vessel attributes for arterioles and venules of the human cerebral cortex
Lorthois, S., Lauwers, F., & Cassot, F. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.11.003 · Cited by 45 · see citing works
Kara, F., van Dongen, E. S., Schliebs, R., van Buchem, M. A., de Groot, H. J. M., & Alia, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.055 · Cited by 44 · see citing works
3D Imaging of vascular networks for biophysical modeling of perfusion distribution within the heart
van den Wijngaard, J. P. H. M., Schwarz, J. C. V., van Horssen, P., van Lier, M. G. J. T. B., Dobbe, J. G. G., Spaan, J. A. E., & Siebes, M. (2012) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2012.11.027 · Cited by 44 · see citing works
p38 MAPK: A Mediator of Hypoxia-Induced Cerebrovascular Inflammation
Sanchez, A. C., Tripathy, D., Yin, X., Desobry, K., Martinez, J. M., Riley, J., Gay, D., Luo, J., & Grammas, P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120829 · Cited by 43 · see citing works
Li, H.-C., Chen, P., Cheng, H.-F., Kuo, Y., & Huang, C. (2019) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2019.2904702 · Cited by 42 · see citing works
- Authors
- Meyer, E. P., Ulmann-Schuler, A., Staufenbiel, M., & Krucker, T.
- Affiliations
- University of Zurich (CH)
- *Department of Zoology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland;
- Novartis Institutes for BioMedical Research (CH)
- Novartis Institutes for BioMedical Research, Inc., Discovery Technologies, Cambridge, MA 02139; and
- Corresponding author
- Krucker, Thomas
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-03-04
- Volume
- 105
- Issue
- 9
- Pages
- 3587-3592
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2265182
- OpenAlex
- W2146417688
- Cited by
- 260
- References
- 60
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 13 · 2023: 15 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 17 · 2018: 18 · 2017: 17 · 2016: 14 · 2015: 10 · 2014: 16 · 2013: 12 · 2012: 20
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Alzheimer's disease, APP23 transgenic mice, cerebral vasculature, microcirculation, amyloid plaques, blood flow, vascular corrosion casts, angiogenesis, early diagnosis, amyloid aggregates
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Capillaries, Cerebrovascular Circulation, Cerebrovascular Disorders, Mice, Transgenic, Corrosion Casting, Models, Animal, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
