Cited by 57Intracerebral and Subarachnoid Hemorrhage ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer’s disease pathogenesis

Castellani, Rudy J, Smith, Mark A, Perry, George, Friedland, Robert P·2004·Neurobiology of Aging

Abstract

Amyloid deposition within cerebral vessels, or cerebral amyloid angiopathy (CAA), is common in advanced age and even more common in Alzheimer's disease. CAA may be complicated by lobar intracerebral hemorrhage, while rare kindreds of autosomal dominant CAA also show propensity for intracerebral hemorrhage, due to germline mutations in specific amyloidogenic precursor proteins and apparent compromise of structural integrity of the blood vessel wall due to marked amyloid deposition. The relationship between cerebral amyloid angiopathy and cognitive dysfunction, however, is less clear. While cognitive dysfunction in familial CAA is likely related to prodigious amyloid deposits and vascular luminal compromise (e.g., hereditary cerebral hemorrhage with angiopathy-Dutch type (HCHWA-D)), cerebral amyloid angiopathy with intracerebral hemorrhage often presents sporadically in cognitively intact elderly patients. Moreover, while about 80% of subjects with Alzheimer's disease have demonstrable amyloid beta within blood vessel walls at autopsy, the vast majority of these fail to suffer clinically relevant intracerebral hemorrhage during life. The remaining 20% manage to progress and die of their disease with virtual no amyloid within blood vessels. Thus, the role of amyloid beta deposits in cerebral vessels as regards cognitive function on the one hand, and tendency for hemorrhage on the other, remain to be resolved for sporadic late onset Alzheimer's disease and CAA. Recent studies on…

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Crossref · 10.1016/j.neurobiolaging.2003.12.019

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Authors
Castellani, R. J., Smith, M. A., Perry, G., & Friedland, R. P.
Affiliations
  • Michigan State University (US)
  • Case Western Reserve University (US)
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2004-05
Volume
25
Issue
5
Pages
599-602
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2077801277
Cited by
57
References
33
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 3 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
cerebral amyloid angiopathy, Alzheimer's disease, intracerebral hemorrhage, amyloid-beta deposition, cognitive impairment, APP23 transgenic mice, passive immunization, oxidative stress, chronic stress, vascular wall integrity, germline mutations
MeSH terms
Alzheimer Disease, Amyloid, Animals, Blood Vessels, Brain, Humans, Cerebral Amyloid Angiopathy

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