Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer’s disease pathogenesis
Abstract
Amyloid deposition within cerebral vessels, or cerebral amyloid angiopathy (CAA), is common in advanced age and even more common in Alzheimer's disease. CAA may be complicated by lobar intracerebral hemorrhage, while rare kindreds of autosomal dominant CAA also show propensity for intracerebral hemorrhage, due to germline mutations in specific amyloidogenic precursor proteins and apparent compromise of structural integrity of the blood vessel wall due to marked amyloid deposition. The relationship between cerebral amyloid angiopathy and cognitive dysfunction, however, is less clear. While cognitive dysfunction in familial CAA is likely related to prodigious amyloid deposits and vascular luminal compromise (e.g., hereditary cerebral hemorrhage with angiopathy-Dutch type (HCHWA-D)), cerebral amyloid angiopathy with intracerebral hemorrhage often presents sporadically in cognitively intact elderly patients. Moreover, while about 80% of subjects with Alzheimer's disease have demonstrable amyloid beta within blood vessel walls at autopsy, the vast majority of these fail to suffer clinically relevant intracerebral hemorrhage during life. The remaining 20% manage to progress and die of their disease with virtual no amyloid within blood vessels. Thus, the role of amyloid beta deposits in cerebral vessels as regards cognitive function on the one hand, and tendency for hemorrhage on the other, remain to be resolved for sporadic late onset Alzheimer's disease and CAA. Recent studies on…
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A significant fraction of Alzheimer's disease patients is affected by severe vasculopathy.
“as a significant fraction of these patients is affected by severe vasculopathy (Castellani et al., 2004).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Castellani et al., 2004
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
Knudsen, K. A., Rosand, J., Karluk, D., & Greenberg, S. M. (2001) · Neurology · doi:10.1212/wnl.56.4.537 · Cited by 1,015 · see citing works
Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A. (1996) · Neurology · doi:10.1212/wnl.46.6.1592 · Cited by 561 · see citing works
Grabowski, T. J., Cho, H. S., Vonsattel, J. P. G., Rebeck, G. W., & Greenberg, S. M. (2001) · Annals of Neurology · doi:10.1002/ana.1009 · Cited by 523 · see citing works
Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy
Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., & Jucker, M. (2002) · Science · doi:10.1126/science.1078259 · Cited by 511 · see citing works
Exercitatio anatomica de motv cordis et sangvinis in animalibvs
Harvey, W., De Landau, H., & Library, B. (1628) · doi:10.5479/sil.126677.39088002685501 · Cited by 420 · see citing works
Premkumar, D. R., Cohen, D., Hedera, P., Friedland, R. P., & Kalaria, R. N. (1996) · Europe PMC (PubMed Central) · Cited by 345 · see citing works
Self-citationCerebral amyloid angiopathy and cognitive function: The HAAS autopsy study
Pfeifer, L. A., White, L. R., Ross, G. W., Petrovitch, H., & Launer, L. J. (2002) · Neurology · doi:10.1212/wnl.58.11.1629 · Cited by 338 · see citing works
Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy
Winkler, D. T., Bondolfi, L., Herzig, M. C., Jann, L., Calhoun, M. E., Wiederhold, K., Tolnay, M., Staufenbiel, M., & Jucker, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01619.2001 · Cited by 287 · see citing works
Cerebral Amyloid Angiopathies: A Pathologic, Biochemical, and Genetic View
Révész, T., Ghiso, J. A., Lashley, T., Plant, G. T., Rostagno, A. A., Frangione, B., & Holton, J. L. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.9.885 · Cited by 286 · see citing works
High frequency of apolipoprotein E ϵ2 Allele in hemorrhage due to cerebral amyloid angiopathy
Nicoll, J. A. R., Burnett, C., Love, S., Graham, D. I., Dewar, D., Ironside, J. W., Stewart, J., & Vinters, H. V. (1997) · Annals of Neurology · doi:10.1002/ana.410410607 · Cited by 284 · see citing works
Sporadic and Familial Cerebral Amyloid Angiopathies
Révész, T., Holton, J. L., Lashley, T., Plant, G. T., Rostagno, A. A., Ghiso, J. A., & Frangione, B. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00449.x · Cited by 199 · see citing works
Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain
Smith, M. A., Casadesús, G., Joseph, J. A., & Perry, G. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01021-3 · Cited by 189 · see citing works
Self-citationIntracellular APP Processing and Aβ Production in Alzheimer Disease
Wilson, C., Doms, R. W., & Lee, V. M. ‐. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199908000-00001 · Cited by 187 · see citing works
Virchow, R. (1854) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01930815 · Cited by 178 · see citing works
Natté, R., Maat‐Schieman, M. L. C., Haan, J., Bornebroek, M., Roos, R. A. C., & Van Duinen, S. G. (2001) · Annals of Neurology · doi:10.1002/ana.10040 · Cited by 166 · see citing works
Metabolic, Metallic, and Mitotic Sources of Oxidative Stress in Alzheimer Disease
Smith, M. A., Nunomura, A., Zhu, X., Takeda, A., & Perry, G. L. (2000) · Antioxidants and Redox Signaling · doi:10.1089/15230860050192198 · Cited by 151 · see citing works
Self-citationThe Neuropathological Diagnosis of Alzheimer’s Disease: Clinical-Pathological Studies
Hyman, B. T. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00066-3 · Cited by 143 · see citing works
Cadavid, D., Mena, H., Koeller, K. K., & Frommelt, R. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.9.768 · Cited by 137 · see citing works
Holton, J. L., Ghiso, J. A., Lashley, T., Rostagno, A. A., Guérin, C. J., Gibb, G., Houlden, H., Ayling, H., Martinian, L., Anderton, B. H., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63993-4 · Cited by 131 · see citing works
Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study
Jellinger, K. A., & Attems, J. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0634-5 · Cited by 121 · see citing works
Failure of inactivation of Duchenne dystrophy X‐chromosome in one of female identical twins
Gómez, M. R., Engel, A. G., Dewald, G. W., & Peterson, H. A. (1977) · Neurology · doi:10.1212/wnl.27.6.537 · Cited by 96 · see citing works
Risk Factors for Cerebral Amyloid Angiopathy in the Elderly
Yamada, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04797.x · Cited by 88 · see citing works
Vidal, R., Calero, M., Piccardo, P., Farlow, M. R., Unverzagt, F. W., Méndez, E., Jiménez‐Huete, A., Beavis, R. C., Gallo, G., Gómez‐Tortosa, E., et al. (2000) · Acta Neuropathologica · doi:10.1007/s004010051186 · Cited by 83 · see citing works
Friedreich, N., & Kekulé, A. (1859) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01945246 · Cited by 79 · see citing works
García‐Sierra, F., Hauw, J. J., Duyckaerts, C. J., Wischik, C. M., Luna‐Muñoz, J., & Mena, R. (2000) · Acta Neuropathologica · doi:10.1007/s004010051189 · Cited by 69 · see citing works
Cerebrovascular muscle atrophy is a feature of Alzheimer's disease.
Perry, G., Smith, M. A., McCann, C., Siedlak, S., Jones, P. K., & Friedland, R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00006-7 · Cited by 69 · see citing works
Self-citationKimchi, E. Y., Kajdasz, S. T., Bacskai, B. J., & Hyman, B. T. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.3.274 · Cited by 39 · see citing works
Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders
Verbeek, M., de Waal, R., & Vinters, H. (2000) · Springer Netherlands · doi:10.1007/978-94-017-1007-7 · Cited by 33 · see citing works
Vascular Variant of Alzheimer's Disease Characterized by Severe Plaque-Like β Protein Angiopathy
Yamada, M., Itoh, Y., Suematsu, N., Otomo, E., & Matsushita, M. (1997) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106626 · Cited by 23 · see citing works
Giannakopoulos, P., Gold, G., Duc, M., Michel, J., Hof, P. R., & Bouras, C. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017263 · Cited by 22 · see citing works
Clinical Aspects and Diagnostic Criteria of Sporadic CAA-Related Hemorrhage
Greenberg, S. M. (2000) · Springer eBooks · doi:10.1007/978-94-017-1007-7_1 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
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Castellani, R. J., Rolston, R. K., & Smith, M. A. (2010) · Disease-a-Month · doi:10.1016/j.disamonth.2010.06.001 · Cited by 561 · see citing works
Self-citationSmoking and increased Alzheimer's disease risk: A review of potential mechanisms
Durazzo, T. C., Mattsson, N., Weiner, M. W., & Initiative, A. D. N. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.009 · Cited by 461 · see citing works
Boekhoorn, K., Joëls, M., & Lucassen, P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.017 · Cited by 342 · see citing works
Esposito, L., Raber, J., Kekonius, L., Yan, F., Yu, G.-Q., Bien-Ly, N., Puoliväli, J., Scearce-Levie, K., Masliah, E., & Mucke, L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0482-06.2006 · Cited by 254 · see citing works
Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease
TCW, J., & Goate, A. M. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a024539 · Cited by 242 · see citing works
Merlini, M., Meyer, E. P., Ulmann-Schuler, A., & Nitsch, R. M. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0834-y · Cited by 225 · see citing works
Liu, B., Rasool, S., Yang, Z., Glabe, C. G., Schreiber, S. S., Ge, J., & Tan, Z. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090159 · Cited by 182 · see citing works
Structure and function of amyloid in Alzheimer's disease
Morgan, C., Colombres, M., Núñez, M. T., & Inestrosa, N. C. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.10.004 · Cited by 136 · see citing works
Neuropathology of Alzheimer disease: pathognomonic but not pathogenic
Castellani, R. J., Lee, H., Zhu, X., Nunomura, A., Perry, G. L., & Smith, M. A. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0071-y · Cited by 133 · see citing works
Self-citation<i>In Vivo</i> mouse imaging and spectroscopy in drug discovery
Beckmann, N., Kneuer, R., Gremlich, H., Karmouty‐Quintana, H., Blé, F., & Müller, M. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1153 · Cited by 118 · see citing works
Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease
Bourasset, F., Ouellet, M., Tremblay, C., Julien, C., Minh, T. N., Oddo, S., LaFerla, F. M., & Calon, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.01.006 · Cited by 105 · see citing works
Yang, S.-H., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W., & Liu, R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.005 · Cited by 86 · see citing works
The role of iron as a mediator of oxidative stress in Alzheimer disease
Castellani, R. J., Moreira, P. I., Perry, G. L., & Zhu, X. (2012) · BioFactors · doi:10.1002/biof.1010 · Cited by 82 · see citing works
Self-citationCognitive impairment of vascular origin: Neuropathology of cognitive impairment of vascular origin
Ferrer, I. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.08.039 · Cited by 79 · see citing works
Grandjean, J., Schroeter, A., He, P., Tanadini, M., Keist, R., Krstic, D., Konietzko, U., Klohs, J., Nitsch, R. M., & Rudin, M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4762-13.2014 · Cited by 70 · see citing works
“A potential contribution of altered neurovascular coupling should also be considered when interpreting functional impairments in AD patients as derived from fMRI studies, as a significant fraction of these patients is affected by severe vasculopathy (Castellani et al., 2004).”
BackgroundOcular manifestations of Alzheimer's disease in animal models
Parnell, M., Guo, L., Abdi, M., & Cordeiro, M. F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/786494 · Cited by 56 · see citing works
Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid
Austin, S. A., & Katusic, Z. S. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18822474 · Cited by 52 · see citing works
Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments
Wang, H., Sang, N., Zhang, C. M., Raghupathi, R., Tanzi, R. E., & Saunders, A. J. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00329 · Cited by 48 · see citing works
Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41 · see citing works
Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model
Lifshitz, V., Weiss, R., Benromano, T., Kfir, E., Blumenfeld‐Katzir, T., Tempel-Brami, C., Assaf, Y., Xia, W., Wyss‐Coray, T., Weiner, H. L., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.01.006 · Cited by 38 · see citing works
Is passive immunization for Alzheimer's disease ‘alive and well’ or ‘dead and buried’?
Jicha, G. A. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590902828285 · Cited by 37 · see citing works
Burbach, G. J., Vlachos, A., Ghebremedhin, E., Turco, D. D., Coomaraswamy, J., Staufenbiel, M., Jucker, M., & Deller, T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.003 · Cited by 33 · see citing works
Cerebral amyloid angiopathy and Alzheimer’s disease
de Courten‐Myers, G. M. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.004 · Cited by 32 · see citing works
Weiss, R., Lifshitz, V., & Frenkel, D. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.012 · Cited by 26 · see citing works
Microvessel occlusions alter amyloid-beta plaque morphology in a mouse model of Alzheimer’s disease
Zhang, Y., Bander, E. D., Lee, Y., Muoser, C. A., Schaffer, C. B., & Nishimura, N. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19889092 · Cited by 26 · see citing works
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 21 · see citing works
Dementia Associates with Undermedication of Cardiovascular Diseases in the Elderly
Löppönen, M. K., Räihä, I. J., Isoaho, R. E., Vahlberg, T. J., Puolijoki, H., & Kivelä, S. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000093739 · Cited by 21 · see citing works
Current Clinical Applications of Intracranial Vessel Wall MR Imaging
Mattay, R. R., Saucedo, J. F., Lehman, V. T., Xiao, J., Obusez, E. C., Raymond, S. B., Fan, Z., & Song, J. W. (2021) · Seminars in Ultrasound CT and MRI · doi:10.1053/j.sult.2021.07.004 · Cited by 20 · see citing works
Barger, S. W. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-2 · Cited by 19 · see citing works
Molecular Pathology of Alzheimer's Disease
Castellani, R. J., & Perry, G. L. (2013) · Colloquium Series on Neurobiology of Alzheimer s Disease · doi:10.4199/c00095ed1v01y201310alz001 · Cited by 19 · see citing works
Self-citationClinical-pathologic correlations in vascular cognitive impairment and dementia
Flanagan, M. E., Larson, E. B., Latimer, C. S., Cholerton, B., Crane, P. K., Montine, K. S., White, L. R., Keene, C. D., & Montine, T. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.019 · Cited by 17 · see citing works
Xue, Z., He, Z.-W., Yu, J.-J., Cai, Y., Qiu, W.-Y., Pan, A., Gai, W.-P., Cai, H., Luo, X.-G., Ma, C., et al. (2015) · BMC Neurology · doi:10.1186/s12883-015-0327-z · Cited by 16 · see citing works
Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview
Carvalho, C., Correia, S. C., Perry, G. L., Castellani, R. J., & Moreira, P. I. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1367-7 · Cited by 14 · see citing works
Self-citationIlomäki, J., Fanning, L., Keen, C., Sluggett, J. K., Page, A. T., Korhonen, M. J., Meretoja, A., Namara, K. M., & Bell, J. S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190094 · Cited by 14 · see citing works
Srikanth, V. K., Saling, M. M., & Thrift, A. G. (2007) · Elsevier eBooks · doi:10.1016/b978-012088592-3/50023-2 · Cited by 9 · see citing works
Evaluating [68Ga]Ga-p14-032 as a Novel PET Tracer for Diagnosis Cerebral Amyloid Angiopathy
Zhang, Q., Zhao, X., Lei, P., Kung, H. F., Yang, Z., Zhu, L., Wang, S., Zhu, H., Meng, X., Duan, Y., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.702185 · Cited by 7 · see citing works
In Vivo Mouse Imaging and Spectroscopy in Drug Discovery
Beckmann, N., Cannet, C., Rausch, M., Kneuer, R., & Gremlich, H. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0134-7_15 · Cited by 6 · see citing works
Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?
Li, J., Huang, L., Liu, F., Tang, B., & Yan, X. (2017) · BMC Neurology · doi:10.1186/s12883-017-0942-y · Cited by 5 · see citing works
Age exacerbates the effect of myopia on retinal capillaries and string vessels
Lin, C. R., Toychiev, A. H., Ablordeppey, R. K., Srinivas, M., & Benavente-Pérez, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1112396 · Cited by 5 · see citing works
Huang, S., Nunez, J., Toresco, D. L., Wen, C., Slotabec, L. A., Wang, H., Zhang, H., Rouhi, N., Adenawoola, M. I., & Li, J. (2025) · The FASEB Journal · doi:10.1096/fj.202402725rr · Cited by 4 · see citing works
The Pathology of Alzheimer Disease Elicits an In Vivo Immunological Response
Bonda, D., Webber, K. M., Siedlak, S. L., Perry, G. L., Friedland, R. P., & Smith, M. A. (2007) · American Journal of Immunology · doi:10.3844/ajisp.2007.10.14 · Cited by 4 · see citing works
Self-citationCerebral Amyloid Angiopathy in Patients with Cognitive Impairment: Cerebrospinal Fluid Biomarkers
Rothenberg, K. G., Bekris, L. M., Leverenz, J. B., Wu, J. C. N., Lee, J., Statsevych, V., Ruggieri, P. M., & Jones, S. E. (2024) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000539884 · Cited by 3 · see citing works
Exercise, cognition and dementia
Scherder, E., & Eggermont, L. H. P. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9781316529898.019 · Cited by 2 · see citing works
Pedersen, W. A. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.60662-2 · Cited by 1 · see citing works
Lanning, J. D., & Meredith, S. C. (2011) · Springer eBooks · doi:10.1007/978-94-007-2774-8_14 · Cited by 1 · see citing works
Cholesterol Potentiates β-Amyloid Genesis in Cultured Human Umbilical Vein Endothelial Cells
Huang, G.-Z., Xue, Z.-Q., Hu, X., Wan, L., Li, J., Cai, Y., Patrylo, P., Luo, X.-G., Pan, A., & Yan, X.-X. (2016) · Advances in Alzheimer s Disease · doi:10.4236/aad.2016.52002 · Cited by 1 · see citing works
A Brief Introduction to the History of the β-Amyloid Protein (Aβ) of Alzheimer’s Disease
Small, D. H., & Barrow, C. J. (2006) · Springer eBooks · doi:10.1007/978-1-84628-440-3_1
Eggermont, L. H. P. (2007) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Haglund, M. (2005) · Lund University Publications (Lund University)
Castellani, R. J., Lee, H., Petersen, R. B., Zhu, X., & Perry, G. L. (2011) · Therapy · doi:10.2217/thy.11.62
Self-citationCell Cycle Activation and the Amyloid-β Protein in Alzheimer’s Disease
Gustaw, K. A., Casadesús, G., Friedland, R. P., Perry, G. L., & Smith, M. A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-021-8_22
Self-citationPrincz-Kranz, F. L. (2010) · Zurich Open Repository and Archive (University of Zurich) · doi:10.3929/ethz-a-006097535
Meyer, R. A. (2008) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.63864-4
Anderson, H. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.05297-1
Rôle des ADAM dans le processus physiopathologique de la maladie d'Alzheimer
Laumet, G. O. (2010) · theses.fr (ABES) · doi:10.70675/94126786zf990z488ezb471z5f1d5686766c
- Authors
- Castellani, R. J., Smith, M. A., Perry, G., & Friedland, R. P.
- Affiliations
- Michigan State University (US)
- Case Western Reserve University (US)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 25
- Issue
- 5
- Pages
- 599-602
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2077801277
- Cited by
- 57
- References
- 33
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 3 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- cerebral amyloid angiopathy, Alzheimer's disease, intracerebral hemorrhage, amyloid-beta deposition, cognitive impairment, APP23 transgenic mice, passive immunization, oxidative stress, chronic stress, vascular wall integrity, germline mutations
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Blood Vessels, Brain, Humans, Cerebral Amyloid Angiopathy
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