Increased levels of testosterone have little effect on visual cortex plasticity in the kitten
Abstract
We tested the hypothesis that increased levels of sex steroids preceding puberty are an important factor in the termination of the critical period for monocular deprivation. Male kittens were injected with Depo-testosterone in order to elevate plasma testosterone to a higher level than that in normal prepubertal male kittens. Control animals did not receive testosterone injections. All kittens were monocularly deprived for 7-18 days, then cells in the visual cortex were examined electrophysiologically, and an ocular dominance histogram was constructed. Treated animals showed an increase in plasma testosterone (1.82-15.16 ng/mL) when compared with the control animals (0.80 +/- 0.25 ng/mL). The fraction of cells driven exclusively by the experienced eye was slightly lower in the treated animals, and there was a slight increase in the dominance of cells by both eyes. However, in both groups of animals, the majority of cells were dominated by the experienced eye, with no significant difference in the weighted parameter used to describe this dominance. In summary, although there is a slight difference between treated and control animals, the results do not support the hypothesis that elevated levels of sex steroids play a crucial role in the termination of the critical period.
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Early exposure to testosterone in kittens does not close ocular dominance plasticity.
“Further, early exposure to testosterone in kittens does not close ocular dominance plasticity (Daw et al., 1987).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Daw et al., 1987
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Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175 · see citing works
Cortisol reduces plasticity in the kitten visual cortex
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Self-citation(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-30484-3_9
Daw, N. W. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9059-3_9
Self-citationMechanisms of Experience-dependent Prevention of Plasticity in Visual Circuits
Balmer, T. S. (2022) · Digital Archive @ GSU · doi:10.57709/5814205
The Effects of Hormones on The eyes and Blurry Vision in Rabbits, Kittens, Rats, and Humans
Mohammed, I., & Adnan, H. O. (2024) · Egyptian Journal of Veterinary Science · doi:10.21608/ejvs.2024.271130.1859
Horvath (1999) · doi:10.1002/(sici)1096-9861(19991213)415:2
- Authors
- Daw, N. W., Baysinger, K. J., & Parkinson, D.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Journal of Neurobiology
- Publisher
- Wiley
- Published
- 1987-03
- Volume
- 18
- Issue
- 2
- Pages
- 141-154
- ISSN
- 0022-3034 (ISSN-L)
- 1097-4695
- OpenAlex
- W1973738956
- Cited by
- 7
- References
- 47
- Citations by year
- 2024: 1 · 2022: 1 · 2016: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns015070-10)
- National Eye Institute (R01EY000053, R01 EY-00053)
- National Institute of Neurological Disorders and Stroke (P01 NS15070)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- testosterone, sex steroids, monocular deprivation, critical period, visual cortex plasticity, ocular dominance, kittens, prepubertal development, plasma testosterone
- MeSH terms
- Age Factors, Animals, Cats, Critical Period, Psychological, Male, Neuronal Plasticity, Neurons, Testosterone, Visual Cortex
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