The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Ciliary neurotrophic factor
Open accessAbstract
Ciliary neurotrophic factor (CNTF) was first identified and partially purified from embryonic chick eye tissues. Subsequently, it was shown that CNTF is also present in large amounts in sciatic nerves of adult rats and rabbits, which led to its final purification and cloning. CNTF is not secreted by the classical secretory pathway involving the endoplasmatic reticulum and Golgi complex, but can be detected in high quantities within the cytoplasm of myelinating Schwann cells and astrocytes using immunohistochemistry. CNTF supports survival and / or differentiation of a variety of neuronal cell types including sensory, sympathetic and motoneurons. Also, nonneuroanl cells, such as oligodendrocytes, microglial cells, liver cells, and skeletal muscle cells, respond to exogenously administered CNTF, both in vitro and in vivo. During development, expression of CNTF is very low, if indeed it is expressed at all, and the phenotype of mice lacking endogenous CNTF, suggesting that CNTF after inactivation of the CNTF gene by homologous recombination suggests that CNTF does not play a crucial role for responsive cells during embryonic development. However, motoneurons are lost postnatally in mice lacking endogenous CNTF, suggesting that CNTF acts physiologically on the maintenance of these cells. The ability of exogenous CNTF to protect against motoneuron loss following lesion or in other animal models indicates that CNTF might be useful in the treatment of human motoneuron disorders, provided appropriate means of administration can be found. 1994 John Wiley & Sons, Inc.
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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
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Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
de Vos, A. M., Ultsch, M., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,239
Cell death and control of cell survival in the oligodendrocyte lineage
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Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
Sendtner, M., Kreutzberg, G. W., & Thoenen, H. (1990) · Nature · doi:10.1038/345440a0 · Cited by 833
Self-citationThe changing scene of neurotrophic factors
Thoenen, H. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90097-e · Cited by 820
Self-citationLaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D., & Steinberg, R. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11249 · Cited by 719
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Self-citationMultiple extracellular signals are required for long-term oligodendrocyte survival
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Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina
Wen, R., Song, Y., Cheng, T., Matthes, M., Yasumura, D., LaVail, M., & Steinberg, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07377.1995 · Cited by 321
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Metadata
- Authors
- Sendtner, M., Carrol, P., Holtmann, B., Hughes, R. A., & Thoenen, H.
- Venue
- Journal of Neurobiology
- Publisher
- Wiley
- Published
- 1994-11
- Volume
- 25
- Issue
- 11
- Pages
- 1436-1453
- ISSN
- 0022-3034 (ISSN-L)
- 1097-4695
- OpenAlex
- W4211063301
- Cited by
- 253
- References
- 107
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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