A natural fiber complex reduces body weight in the overweight and obese: A double‐blind, randomized, placebo‐controlled study
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Objective: A proprietary natural fiber complex (Litramine IQP G‐002AS) derived from Opuntia ficus‐indica, and standardized on lipophilic activity, was previously shown in preclinical and human studies to reduce dietary fat absorption through gastrointestinal (GI) fat binding. Here, we investigated the efficacy and safety of IQP G‐002AS in body weight reduction. Design and Methods: One hundred twenty‐five overweight and obese adults participated in the study. Subjects were advised on physical activity, and received nutritional counseling, including hypocaloric diet plans (30% energy from fat and 500 kcal deficit/day). After a 2‐week placebo run‐in phase, subjects were randomized to receive either 3 g/day of IQP G‐002AS (IQ) or a placebo. The primary endpoint was change in body weight from baseline; secondary endpoints included additional obesity measures and safety parameters. Results: One hundred twenty‐three subjects completed the 12‐week treatment phase (intention‐to‐treat (ITT) population: 30 male and 93 female; mean BMI: 29.6 ± 2.8 kg/m 2 and age: 45.4 ± 11.3 years). The mean body weight change from baseline was 3.8 ± 1.8 kg in IQ vs. 1.4 ± 2.6 kg in placebo (P < 0.001). More IQ subjects lost at least 5% of their initial body weight compared to placebo (P = 0.027). Compared with placebo, IQ also showed significantly greater reduction in BMI, body fat composition, and waist circumference. IQ was well tolerated with no adverse reactions reported. Conclusions: These results suggest that the natural fiber complex Litramine IQP G‐002AS is effective in promoting weight loss.
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There were no differences in lean body mass between fiber and placebo groups, though both groups lost lean body mass; from total weight lost, the fiber group lost approximately 50% of lean body mass while the placebo group lost approximately 36% of lean body mass, showing that the fiber did not offset lean body mass loss.
“There were no differences in LBM, though both groups did lose LBM suggesting the fiber may have contributed to increased weight loss in the treatment group but did not effectively offset LBM losses in this study; from the total weight lost, the fiber group lost approximately 50% of LBM while the placebo group lost approximately 36% of LBM showing that the fiber did not offset LBM loss [39].”
From Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review (2018) · cites this paper as [39]
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Experimental — accuracy not yet measuredIn a 12-week study with obese women and men, the group assigned to the fiber supplement lost significantly more body weight and body fat than placebo.
“The group assigned to the fiber supplement lost significantly more body weight and body fat than placebo.”
From Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review (2018) · cites this paper as [39]
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- Authors
- Grube, B., Chong, P., Lau, K., & Orzechowski, H.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Chong, Pee‐Win
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 21
- Issue
- 1
- Pages
- 58-64
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC3627296
- OpenAlex
- W1972920113
- Cited by
- 83
- References
- 29
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 3 · 2017: 10 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 2
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Agricultural and Biological Sciences › Food Science › Botanical Research and Applications
- Keywords
- Opuntia ficus-indica, dietary fat absorption, weight loss, overweight, hypocaloric diet, body mass index, body fat content, waist circumference, supplement safety
- MeSH terms
- Adipose Tissue, Adult, Body Composition, Dietary Fiber, Double-Blind Method, Female, Humans, Male, Phytotherapy, Middle Aged, Obesity, Weight Loss, Body Mass Index, Anti-Obesity Agents, Plant Preparations, Opuntia, Overweight, Waist Circumference, Intention to Treat Analysis
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