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Cited by 21Menopause: Health Impacts and TreatmentsLipid metabolism and biosynthesisAdipose Tissue and Metabolism

Postprandial triglycerides and adipose tissue storage of dietary fatty acids: Impact of menopause and estradiol

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Bessesen, Daniel H., Cox‐York, Kimberly A., Hernandez, Teri Lynn, Erickson, Christopher B., Wang, Hong, Jackman, Matt R., Van Pelt, Rachael E.·2015·Obesity
DOI 10.1002/oby.20935PMC PMC4276527
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Abstract

Objectives: Postprandial lipemia worsens after menopause, but the mechanism remains unknown. The hypothesized menopause‐related postprandial lipemia would be (1) associated with reduced storage of dietary fatty acids (FA) as triglyceride (TG) in subcutaneous adipose tissue (SAT) and (2) improved by short‐term estradiol (E 2). Methods: Twenty‐three pre‐ (mean ± SD: 42 ± 4 years) and 22 postmenopausal (55 ± 4 years) women with similar total adiposity were studied. A subset of postmenopausal women (n = 12) were studied following 2 weeks of E 2 (0.15 mg) and matching placebo in a random, cross‐over design. A liquid meal containing 14 C‐oleic acid traced appearance of dietary FA in: serum (postprandial TG), breath (oxidation), and abdominal and femoral SAT (TG storage). Results: Compared to premenopausal women, healthy, lean, postmenopausal women had increased postprandial glucose and insulin and trend for higher TG but had similar dietary FA oxidation and storage. Adipocytes were larger in post‐ compared to premenopausal women, particularly in femoral SAT. Short‐term E 2 reduced postprandial TG and insulin but had no effect on oxidation or storage of dietary FA. E 2 increased the proportion of small adipocytes in femoral (but not abdominal) SAT. Conclusions: Short‐term E 2 attenuated menopause‐related increases in postprandial TG and increased femoral adipocyte hyperplasia but not through increased net storage of dietary FA.

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  • In a randomized double-blind cross-over study, testosterone suppression for 7 days resulted in greater meal fat storage in femoral subcutaneous adipose tissue compared to testosterone rescue.

    “These results are consistent those of a randomized double-blind cross-over study where males underwent testosterone suppression or suppression and rescue for 7 days (117). Compared to the testosterone rescue, testosterone suppression resulted in greater meal fat storage in femoral subcutaneous adipose tissue (117).”

    From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [117]

    The Methods Subjects and Estradiol treatment sections describe a study of women, with a two-week estradiol-versus-placebo crossover in postmenopausal participants—not a seven-day testosterone suppression-and-rescue study in men. The Acute effects of estradiol section reports no change in dietary fatty-acid storage in subcutaneous adipose tissue. No page numbers are available in our copy. (LLM, conf=0.88)

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  • Neither 7 days nor 4 weeks of gonadal hormone suppression in young men using GnRH agonists changes postprandial fat oxidation or meal fat oxidation following a mixed meal.

    “However, neither 7 days (117) nor 4 weeks (115) of gonadal hormone suppression in young men using GnRH agonists changes postprandial fat oxidation (indirect calorimetry) or meal fat oxidation (isotopic tracers) following consumption of a mixed meal.”

    From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [117]

    The Methods Subjects and Estradiol treatment sections describe women, including postmenopausal women given estradiol for two weeks. The Acute effects of estradiol section reports no effect on postprandial nutrient oxidation or the proportion of dietary fatty acids oxidized after a mixed meal. It does not support the specific claim about young men receiving 7 days or 4 weeks of GnRH-agonist hormone suppression; page numbers are unavailable in our copy. (LLM, conf=0.86)

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Authors
Bessesen, D. H., Cox‐York, K. A., Hernandez, T. L., Erickson, C. B., Wang, H., Jackman, M. R., & Van Pelt, R. E.
Affiliations
  • Denver Health Medical Center (US)
  • Colorado State University (US)
  • University of Colorado Anschutz (US)
  • Department of Medicine, Division of Endocrinology, Metabolism and Diabetes University of Colorado Anschutz Medical Campus Aurora Colorado USA
  • Department of Medicine Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus Aurora Colorado USA
ORCID
Venue
Obesity
Publisher
Wiley
Published
2014-10-30
Volume
23
Issue
1
Pages
145-153
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
DOI
10.1002/oby.20935
PMC
PMC4276527
OpenAlex
W1518369016
Cited by
21
References
37
Citations by year
2025: 4 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2
FWCI
1.88
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (DK077992, DK088105, DK002935, AG000279, DK038088, HD057022, DK048520, TR000154)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
postprandial lipemia, menopause, estradiol, postmenopausal women, triglyceride storage, subcutaneous adipose tissue, adipocyte size, adipocyte hyperplasia, oleic acid, insulin, adipose tissue lipolysis
MeSH terms
Adult, Dietary Fats, Estradiol, Fatty Acids, Female, Humans, Menopause, Middle Aged, Triglycerides, Postprandial Period, Subcutaneous Fat, Lipid Metabolism, Meals

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