Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Open accessAbstract
OBJECTIVE: Binge-eating disorder (BED) is a prevalent psychiatric disorder associated with obesity. Few evidence-based treatments exist for BED, particularly pharmacological options. This study tested the efficacy of naltrexone/bupropion for BED. METHODS: ) were randomized to placebo (n = 46) or naltrexone/bupropion (n = 43), with randomization stratified by obesity status and gender; 92.1% completed post-treatment assessments. RESULTS: Mixed models of binge-eating frequency revealed significant reductions that did not differ significantly between naltrexone/bupropion and placebo. Logistic regression of binge-eating remission rates revealed that naltrexone/bupropion and placebo did not differ significantly. Obesity status did not predict, or moderate, binge-eating outcomes considered either continuously or categorically. Mixed models revealed that naltrexone/bupropion was associated with significantly greater percentage weight loss than placebo. Logistic regression revealed that naltrexone/bupropion had significantly higher rates of attaining ≥5% weight loss than placebo (27.9% vs. 6.5%). Obesity status did not predict or moderate weight-loss outcomes. CONCLUSIONS: Naltrexone/bupropion did not demonstrate effectiveness for reducing binge eating relative to placebo but showed effectiveness for weight reduction in patients with BED. Obesity status did not predict or moderate medication outcomes.
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In a 12-week randomized, double-blind, placebo-controlled trial of 89 adults with BED, naltrexone/bupropion did not significantly reduce binge-eating frequency or remission rates compared to placebo.
“In a 12-week randomized, double-blind, placebo-controlled trial of 89 adults with BED, naltrexone/bupropion did not significantly reduce binge-eating frequency or remission rates compared to placebo.”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [140]
Obesity status did not influence treatment effects in that trial.
“Obesity status did not influence treatment effects.”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [140]
In that trial, naltrexone/bupropion led to significantly greater weight loss: 27.9% of treated participants achieved ≥5% weight reduction versus 6.5% with placebo.
“However, it led to significantly greater Weight loss: 27.9% of treated participants achieved ≥ 5% Weight reduction versus 6.5% with placebo.”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [140]
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Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms
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Self-citationSandhu, J. K., Kumar, R., Bilasy, S. E., Chen, G., Yang, C., & El‐Shamy, A. (2026) · Obesities · doi:10.3390/obesities6030029
Eramo, B., Sepe, C., Friuli, M., Campagna, A., Romano, A., & Gaetani, S. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108279
Jebeile, H., Brennan, L., Burrows, T. W., Garcia, X. D. L. P., Ralph, A. F., Saluja, S., Atlantis, E. E., Garnett, S. P., Harrison, C. J., House, E. T., et al. (2026) · The Medical Journal of Australia · doi:10.5694/mja2.70235
- Authors
- Grilo, C. M., Lydecker, J. A., Jastreboff, A. M., Pittman, B., & McKee, S. A.
- Affiliations
- Yale University (US)
- Corresponding author
- Grilo, Carlos M.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2023-09-26
- Volume
- 31
- Issue
- 11
- Pages
- 2762-2773
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC10600891
- OpenAlex
- W4387036146
- Cited by
- 47
- References
- 45
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 20 · 2023: 1
- FWCI
- 13.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK112771, K23‐DK‐115893, UL1‐TR‐001863)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- binge eating disorder, naltrexone/bupropion, pharmacotherapy, binge eating frequency, weight loss
- MeSH terms
- Bulimia, Double-Blind Method, Female, Humans, Male, Middle Aged, Naltrexone, Obesity, Weight Loss, Bupropion, Treatment Outcome, Binge-Eating Disorder
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