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Cited by 141Pharmacology and Obesity TreatmentBariatric Surgery and OutcomesObesity and Health Practices

American Association of Clinical Endocrinology Consensus Statement: Algorithm for the Evaluation and Treatment of Adults with Obesity/Adiposity-Based Chronic Disease – 2025 Update

Nadolsky, Karl, Garvey, W. Timothy, Agarwal, Monica, Bonnecaze, Alex, Burguera, Bartolome, Chaplin, Michelle DeGeeter, Griebeler, Marcio L., Harris, Samantha R. +4 more·2025·Endocrine Practice
DOI 10.1016/j.eprac.2025.07.017
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Abstract

Objective This 2025 consensus statement provides evidence-based visual guidance in graphic algorithms and a summary of evidence to assist health care professionals and adults with obesity and adiposity-based chronic disease (ABCD) in shared decision making to improve care and achieve health goals. Methods AACE selected a task force of medical experts to update the 2016 AACE algorithm for the medical care of patients with obesity and align this algorithm update with related AACE clinical guidance. Details on surgical and procedural therapies for obesity treatment as well as the care of pediatric-aged patients are beyond the scope of this algorithm. Results The algorithm includes 11 sections: (1) principles of person-centered and complication-centric management of obesity/ABCD, (2) care model for people with obesity/ABCD: screening and diagnosis, (3) diagnosis: anthropometric component, (4) diagnosis: clinical component, (5) individualized treatment plan, therapeutic goals, and follow-up, (6) response to therapy and weight-loss targets for people with ABCD, (7) behavioral/lifestyle therapy for people with obesity/ABCD, (8) hierarchies of preferred medications for complication-centric care of people with ABCD, (9) lower-cost pharmacologic step therapy for ABCD, (10) medications for obesity: individualization of therapy, and (11) medications for obesity approved by the U.S. Food and Drug Administration. Conclusions This 2025 algorithm for the medical care of adults with obesity u…

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Authors
Nadolsky, K., Garvey, W. T., Agarwal, M., Bonnecaze, A., Burguera, B., Chaplin, M. D., Griebeler, M. L., Harris, S. R., Schellinger, J. N., Simonetti, J., Srinath, R., & Yumuk, V.
Affiliations
  • Michigan State University (US)
  • University of Alabama at Birmingham (US)
  • Cleveland Clinic (US)
  • Scripps Clinic (US)
  • The University of Texas Southwestern Medical Center (US)
  • University of Utah (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • Istanbul University-Cerrahpaşa (TR)
ORCID
Venue
Endocrine Practice
Publisher
Elsevier BV
Published
2025-11
Volume
31
Issue
11
Pages
1351-1394
ISSN
1530-891X (ISSN-L)
DOI
10.1016/j.eprac.2025.07.017
OpenAlex
W4414229616
Cited by
141
References
91
Citations by year
2026: 135 · 2025: 6
FWCI
79.73
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Endocrine Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
Keywords
obesity, weight loss targets, anti-obesity drugs, step therapy, shared decision-making, personalized treatment
MeSH terms
Adult, Algorithms, Chronic Disease, Endocrinology, Humans, Obesity, Societies, Medical, United States, Consensus, Adiposity

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